High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic.
Recognizing the influence of pathogen diversity on infection dynamics is crucial for mitigating emerging infectious diseases. Characterising such diversity is often complex, for instance when multiple pathogen variants exist that interact differently with the environment and host. Here, we explore g...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-10-01
|
| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1012579 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850180243147456512 |
|---|---|
| author | Moira Kelly Christina A Cuomo Wouter Beukema Salvador Carranza Jesse Erens Marleen Foubert Zhimin Li Stefan Lötters Vanessa Schulz Sebastian Steinfartz Sarah Van Praet Michael Veith Frank Pasmans An Martel |
| author_facet | Moira Kelly Christina A Cuomo Wouter Beukema Salvador Carranza Jesse Erens Marleen Foubert Zhimin Li Stefan Lötters Vanessa Schulz Sebastian Steinfartz Sarah Van Praet Michael Veith Frank Pasmans An Martel |
| author_sort | Moira Kelly |
| collection | DOAJ |
| description | Recognizing the influence of pathogen diversity on infection dynamics is crucial for mitigating emerging infectious diseases. Characterising such diversity is often complex, for instance when multiple pathogen variants exist that interact differently with the environment and host. Here, we explore genotypic and phenotypic variation of Batrachochytrium salamandrivorans (Bsal), an emerging fungal pathogen that is driving declines among an increasing number of European amphibian species. For thirteen isolates, spanning most of the known temporal and geographical Bsal range in Europe, we mapped phenotypic diversity through numerous measurements that describe varying reproductive rates in vitro across a range of temperatures. Bsal isolates are revealed to have different thermal optima and tolerances, with phenotypic variation correlating with genomic diversity. Using a mechanistic niche model of the fire salamander (Salamandra salamandra) as an example, we illustrate how host steady-state body temperature and Bsal thermal range variation may influence pathogen growth through space and time across Europe. Our combined findings show how the identity of emergent pathogen variants may strongly influence when and which host populations are most at risk. |
| format | Article |
| id | doaj-art-208dec87c7264cc4a51cc9b8424a5bf1 |
| institution | OA Journals |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-208dec87c7264cc4a51cc9b8424a5bf12025-08-20T02:18:15ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742024-10-012010e101257910.1371/journal.ppat.1012579High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic.Moira KellyChristina A CuomoWouter BeukemaSalvador CarranzaJesse ErensMarleen FoubertZhimin LiStefan LöttersVanessa SchulzSebastian SteinfartzSarah Van PraetMichael VeithFrank PasmansAn MartelRecognizing the influence of pathogen diversity on infection dynamics is crucial for mitigating emerging infectious diseases. Characterising such diversity is often complex, for instance when multiple pathogen variants exist that interact differently with the environment and host. Here, we explore genotypic and phenotypic variation of Batrachochytrium salamandrivorans (Bsal), an emerging fungal pathogen that is driving declines among an increasing number of European amphibian species. For thirteen isolates, spanning most of the known temporal and geographical Bsal range in Europe, we mapped phenotypic diversity through numerous measurements that describe varying reproductive rates in vitro across a range of temperatures. Bsal isolates are revealed to have different thermal optima and tolerances, with phenotypic variation correlating with genomic diversity. Using a mechanistic niche model of the fire salamander (Salamandra salamandra) as an example, we illustrate how host steady-state body temperature and Bsal thermal range variation may influence pathogen growth through space and time across Europe. Our combined findings show how the identity of emergent pathogen variants may strongly influence when and which host populations are most at risk.https://doi.org/10.1371/journal.ppat.1012579 |
| spellingShingle | Moira Kelly Christina A Cuomo Wouter Beukema Salvador Carranza Jesse Erens Marleen Foubert Zhimin Li Stefan Lötters Vanessa Schulz Sebastian Steinfartz Sarah Van Praet Michael Veith Frank Pasmans An Martel High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic. PLoS Pathogens |
| title | High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic. |
| title_full | High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic. |
| title_fullStr | High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic. |
| title_full_unstemmed | High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic. |
| title_short | High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic. |
| title_sort | high phenotypic diversity correlated with genomic variation across the european batrachochytrium salamandrivorans epizootic |
| url | https://doi.org/10.1371/journal.ppat.1012579 |
| work_keys_str_mv | AT moirakelly highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT christinaacuomo highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT wouterbeukema highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT salvadorcarranza highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT jesseerens highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT marleenfoubert highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT zhiminli highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT stefanlotters highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT vanessaschulz highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT sebastiansteinfartz highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT sarahvanpraet highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT michaelveith highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT frankpasmans highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic AT anmartel highphenotypicdiversitycorrelatedwithgenomicvariationacrosstheeuropeanbatrachochytriumsalamandrivoransepizootic |