Effect of rifampicin on the kidney of albino rats
The study was designed to investigate the effect of rifampicin on the kidney biomarkers and histopathology of kidney of albino rats. 42 albino rats were used and rifampicin was administered at 1.10mg/120gBW and 0.55mg/120gBW for intervals of 20, 40 and 60days.Animals were sacrificed 24 hours after...
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| Language: | English |
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Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2013-07-01
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| Series: | Journal of Applied Sciences and Environmental Management |
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| Online Access: | https://www.Ajol.Info/index.php/jasem/article/view/90479 |
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| author | DE Peters AO Chike |
| author_facet | DE Peters AO Chike |
| author_sort | DE Peters |
| collection | DOAJ |
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The study was designed to investigate the effect of rifampicin on the kidney biomarkers and histopathology of kidney of albino rats. 42 albino rats were used and rifampicin was administered at 1.10mg/120gBW and 0.55mg/120gBW for intervals of 20, 40 and 60days.Animals were sacrificed 24 hours after the last day of administration and blood samples were collected for the estimation of urea and creatinine levels sodium , potassium, chloride and bicarbonate ion concentrations. Result from this study indicates that urea and creatinine levels in a dose and time dependent manner, significantly increased (p<0.05) all through the duration of the study when compared with the control value. Significant decrease (p<0.05) was observed for sodium ion concentration in a dose and time dependent manner also while potassium, chloride and bicarbonate ions were non significantly changed (p>0.05). Histological examination of the kidney revealed an inflammation of the glomeruli for 1.10mg/120gBW treated group in 60days. In conclusion, prolonged treatment of tuberculosis patients with rifampicin could result to nephrotoxicity.
KEY WORDS: Rifampicin Tuberculosis, Urea, creatinine, Sodium, Potassium, Chloride, Bicarbonate
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| format | Article |
| id | doaj-art-208dcda4e3d841b1851f889e2b157531 |
| institution | Kabale University |
| issn | 2659-1502 2659-1499 |
| language | English |
| publishDate | 2013-07-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj-art-208dcda4e3d841b1851f889e2b1575312025-02-08T19:52:12ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992013-07-01171Effect of rifampicin on the kidney of albino ratsDE PetersAO Chike The study was designed to investigate the effect of rifampicin on the kidney biomarkers and histopathology of kidney of albino rats. 42 albino rats were used and rifampicin was administered at 1.10mg/120gBW and 0.55mg/120gBW for intervals of 20, 40 and 60days.Animals were sacrificed 24 hours after the last day of administration and blood samples were collected for the estimation of urea and creatinine levels sodium , potassium, chloride and bicarbonate ion concentrations. Result from this study indicates that urea and creatinine levels in a dose and time dependent manner, significantly increased (p<0.05) all through the duration of the study when compared with the control value. Significant decrease (p<0.05) was observed for sodium ion concentration in a dose and time dependent manner also while potassium, chloride and bicarbonate ions were non significantly changed (p>0.05). Histological examination of the kidney revealed an inflammation of the glomeruli for 1.10mg/120gBW treated group in 60days. In conclusion, prolonged treatment of tuberculosis patients with rifampicin could result to nephrotoxicity. KEY WORDS: Rifampicin Tuberculosis, Urea, creatinine, Sodium, Potassium, Chloride, Bicarbonate https://www.Ajol.Info/index.php/jasem/article/view/90479Rifampicin TuberculosisUreacreatinineSodiumPotassiumChloride |
| spellingShingle | DE Peters AO Chike Effect of rifampicin on the kidney of albino rats Journal of Applied Sciences and Environmental Management Rifampicin Tuberculosis Urea creatinine Sodium Potassium Chloride |
| title | Effect of rifampicin on the kidney of albino rats |
| title_full | Effect of rifampicin on the kidney of albino rats |
| title_fullStr | Effect of rifampicin on the kidney of albino rats |
| title_full_unstemmed | Effect of rifampicin on the kidney of albino rats |
| title_short | Effect of rifampicin on the kidney of albino rats |
| title_sort | effect of rifampicin on the kidney of albino rats |
| topic | Rifampicin Tuberculosis Urea creatinine Sodium Potassium Chloride |
| url | https://www.Ajol.Info/index.php/jasem/article/view/90479 |
| work_keys_str_mv | AT depeters effectofrifampicinonthekidneyofalbinorats AT aochike effectofrifampicinonthekidneyofalbinorats |