The influence of multiple-dose oxcarbazepine on the metabolism of single-dose quetiapine. In vivo experiment in rats
Objective: Psychiatric and neurologic disorders are susceptible to polypharmacy having a higher risk of developing drug-drug interactions. Quetiapine, a frequently used atypical antipsychotic, is extensively metabolized by cytochrome P450 3A4 isoenzyme, while oxcarbazepine, an antiepileptic drug, an...
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| Format: | Article |
| Language: | English |
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Sciendo
2025-03-01
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| Series: | Acta Marisiensis - Seria Medica |
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| Online Access: | https://doi.org/10.2478/amma-2025-0010 |
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| author | Ciocotișan Iulia-Maria Muntean Dana Maria Gherman Luciana-Mădălina Vlase Laurian |
| author_facet | Ciocotișan Iulia-Maria Muntean Dana Maria Gherman Luciana-Mădălina Vlase Laurian |
| author_sort | Ciocotișan Iulia-Maria |
| collection | DOAJ |
| description | Objective: Psychiatric and neurologic disorders are susceptible to polypharmacy having a higher risk of developing drug-drug interactions. Quetiapine, a frequently used atypical antipsychotic, is extensively metabolized by cytochrome P450 3A4 isoenzyme, while oxcarbazepine, an antiepileptic drug, analog of carbamazepine, is a mild-to-moderate inducer of the same isoenzyme. This study aimed to evaluate the pharmacokinetic interaction between a single dose of quetiapine and multiple doses of oxcarbazepine, as pretreatment, compared to quetiapine single-dose alone in rats. |
| format | Article |
| id | doaj-art-208af1c427b84c3cbe7a88b019facee7 |
| institution | DOAJ |
| issn | 2668-7763 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Marisiensis - Seria Medica |
| spelling | doaj-art-208af1c427b84c3cbe7a88b019facee72025-08-20T03:17:35ZengSciendoActa Marisiensis - Seria Medica2668-77632025-03-01711535910.2478/amma-2025-0010The influence of multiple-dose oxcarbazepine on the metabolism of single-dose quetiapine. In vivo experiment in ratsCiocotișan Iulia-Maria0Muntean Dana Maria1Gherman Luciana-Mădălina2Vlase Laurian31Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania1Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania2Experimental Centre, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania1Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaObjective: Psychiatric and neurologic disorders are susceptible to polypharmacy having a higher risk of developing drug-drug interactions. Quetiapine, a frequently used atypical antipsychotic, is extensively metabolized by cytochrome P450 3A4 isoenzyme, while oxcarbazepine, an antiepileptic drug, analog of carbamazepine, is a mild-to-moderate inducer of the same isoenzyme. This study aimed to evaluate the pharmacokinetic interaction between a single dose of quetiapine and multiple doses of oxcarbazepine, as pretreatment, compared to quetiapine single-dose alone in rats.https://doi.org/10.2478/amma-2025-0010pharmacokineticsmetabolismquetiapinenorquetiapineoxcarbazepine |
| spellingShingle | Ciocotișan Iulia-Maria Muntean Dana Maria Gherman Luciana-Mădălina Vlase Laurian The influence of multiple-dose oxcarbazepine on the metabolism of single-dose quetiapine. In vivo experiment in rats Acta Marisiensis - Seria Medica pharmacokinetics metabolism quetiapine norquetiapine oxcarbazepine |
| title | The influence of multiple-dose oxcarbazepine on the metabolism of single-dose quetiapine. In vivo experiment in rats |
| title_full | The influence of multiple-dose oxcarbazepine on the metabolism of single-dose quetiapine. In vivo experiment in rats |
| title_fullStr | The influence of multiple-dose oxcarbazepine on the metabolism of single-dose quetiapine. In vivo experiment in rats |
| title_full_unstemmed | The influence of multiple-dose oxcarbazepine on the metabolism of single-dose quetiapine. In vivo experiment in rats |
| title_short | The influence of multiple-dose oxcarbazepine on the metabolism of single-dose quetiapine. In vivo experiment in rats |
| title_sort | influence of multiple dose oxcarbazepine on the metabolism of single dose quetiapine in vivo experiment in rats |
| topic | pharmacokinetics metabolism quetiapine norquetiapine oxcarbazepine |
| url | https://doi.org/10.2478/amma-2025-0010 |
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