The influence of multiple-dose oxcarbazepine on the metabolism of single-dose quetiapine. In vivo experiment in rats
Objective: Psychiatric and neurologic disorders are susceptible to polypharmacy having a higher risk of developing drug-drug interactions. Quetiapine, a frequently used atypical antipsychotic, is extensively metabolized by cytochrome P450 3A4 isoenzyme, while oxcarbazepine, an antiepileptic drug, an...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2025-03-01
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| Series: | Acta Marisiensis - Seria Medica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/amma-2025-0010 |
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| Summary: | Objective: Psychiatric and neurologic disorders are susceptible to polypharmacy having a higher risk of developing drug-drug interactions. Quetiapine, a frequently used atypical antipsychotic, is extensively metabolized by cytochrome P450 3A4 isoenzyme, while oxcarbazepine, an antiepileptic drug, analog of carbamazepine, is a mild-to-moderate inducer of the same isoenzyme. This study aimed to evaluate the pharmacokinetic interaction between a single dose of quetiapine and multiple doses of oxcarbazepine, as pretreatment, compared to quetiapine single-dose alone in rats. |
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| ISSN: | 2668-7763 |