Platinum(II) Complexes with Tetradentate Schiff Bases as Ligands: Synthesis, Characterization and Detection of DNA Interaction by Differential Pulse Voltammetry
Five sterically hindered platinum(II) complexes with tetradentate schiff bases as ligands, [Pt(L)] (L= N,N′-bisalicylidene-1,2-ethylenediamine (L1), N,N′-bisalicylidene-1,2-cyclohexanediamine (L2), N,N′-bis(5-hydroxyl-salicylidene)-1,2-cyclohexanediamine (L3), N,N′-bisalicylidene-1,2-diphenyl-ethyle...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/634572 |
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| author | Lijun Li Chao Tian Cheng Wang Guangyuan Wang Lianzeng Wang Jianlong Du |
| author_facet | Lijun Li Chao Tian Cheng Wang Guangyuan Wang Lianzeng Wang Jianlong Du |
| author_sort | Lijun Li |
| collection | DOAJ |
| description | Five sterically hindered platinum(II) complexes with tetradentate schiff bases as ligands, [Pt(L)] (L= N,N′-bisalicylidene-1,2-ethylenediamine (L1), N,N′-bisalicylidene-1,2-cyclohexanediamine (L2), N,N′-bis(5-hydroxyl-salicylidene)-1,2-cyclohexanediamine (L3), N,N′-bisalicylidene-1,2-diphenyl-ethylenediamine (L4) and N,N′-bis(3-tert-butyl-5-methyl-salicylidene)-1,2-diphenylethylenediamine (L5) ) have been synthesized and characterized by IR spectroscopy and elemental analysis. The sterical hindrance of antitumor drug candidates potentially makes them less susceptible to deactivation by sulphur containing proteins and helping to overcome resistance mechanisms. The interaction of these metal complexes with fish sperm single-stranded DNA (ssDNA) was studied electrochemically based on the oxidation signals of guanine and adenine. Differential pulse voltammetry was employed to monitor the DNA interaction in solution by using renewable pencil graphite electrode. The results indicate that ligands with different groups can strongly affect the interaction between [Pt(L)] complexes and ssDNA due to sterical hindrances and complex [Pt(L1)] has the best interaction with DNA among the five complexes. |
| format | Article |
| id | doaj-art-20895c19a40343e3ac0663012707e9c6 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-20895c19a40343e3ac0663012707e9c62025-02-03T01:23:54ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01931422143010.1155/2012/634572Platinum(II) Complexes with Tetradentate Schiff Bases as Ligands: Synthesis, Characterization and Detection of DNA Interaction by Differential Pulse VoltammetryLijun Li0Chao Tian1Cheng Wang2Guangyuan Wang3Lianzeng Wang4Jianlong Du5College of Chemistry & Environmental Science Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, ChinaCollege of Chemistry & Environmental Science Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, ChinaCollege of Chemistry & Environmental Science Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, ChinaCollege of Chemistry & Environmental Science Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, ChinaCollege of Chemistry & Environmental Science Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, ChinaCollege of Chemistry & Environmental Science Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, ChinaFive sterically hindered platinum(II) complexes with tetradentate schiff bases as ligands, [Pt(L)] (L= N,N′-bisalicylidene-1,2-ethylenediamine (L1), N,N′-bisalicylidene-1,2-cyclohexanediamine (L2), N,N′-bis(5-hydroxyl-salicylidene)-1,2-cyclohexanediamine (L3), N,N′-bisalicylidene-1,2-diphenyl-ethylenediamine (L4) and N,N′-bis(3-tert-butyl-5-methyl-salicylidene)-1,2-diphenylethylenediamine (L5) ) have been synthesized and characterized by IR spectroscopy and elemental analysis. The sterical hindrance of antitumor drug candidates potentially makes them less susceptible to deactivation by sulphur containing proteins and helping to overcome resistance mechanisms. The interaction of these metal complexes with fish sperm single-stranded DNA (ssDNA) was studied electrochemically based on the oxidation signals of guanine and adenine. Differential pulse voltammetry was employed to monitor the DNA interaction in solution by using renewable pencil graphite electrode. The results indicate that ligands with different groups can strongly affect the interaction between [Pt(L)] complexes and ssDNA due to sterical hindrances and complex [Pt(L1)] has the best interaction with DNA among the five complexes.http://dx.doi.org/10.1155/2012/634572 |
| spellingShingle | Lijun Li Chao Tian Cheng Wang Guangyuan Wang Lianzeng Wang Jianlong Du Platinum(II) Complexes with Tetradentate Schiff Bases as Ligands: Synthesis, Characterization and Detection of DNA Interaction by Differential Pulse Voltammetry E-Journal of Chemistry |
| title | Platinum(II) Complexes with Tetradentate Schiff Bases as Ligands: Synthesis, Characterization and Detection of DNA Interaction by Differential Pulse Voltammetry |
| title_full | Platinum(II) Complexes with Tetradentate Schiff Bases as Ligands: Synthesis, Characterization and Detection of DNA Interaction by Differential Pulse Voltammetry |
| title_fullStr | Platinum(II) Complexes with Tetradentate Schiff Bases as Ligands: Synthesis, Characterization and Detection of DNA Interaction by Differential Pulse Voltammetry |
| title_full_unstemmed | Platinum(II) Complexes with Tetradentate Schiff Bases as Ligands: Synthesis, Characterization and Detection of DNA Interaction by Differential Pulse Voltammetry |
| title_short | Platinum(II) Complexes with Tetradentate Schiff Bases as Ligands: Synthesis, Characterization and Detection of DNA Interaction by Differential Pulse Voltammetry |
| title_sort | platinum ii complexes with tetradentate schiff bases as ligands synthesis characterization and detection of dna interaction by differential pulse voltammetry |
| url | http://dx.doi.org/10.1155/2012/634572 |
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