Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review
Chronic atrophic gastritis (CAG) is a prevalent digestive system disease characterized by atrophy of the gastric mucosa and the disappearance of inherent gastric glands. According to the theory of Correa’s cascade, CAG is an important pathological stage in the transformation from normal condition to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1513426/full |
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| author | Weihong Kuang Weihong Kuang Weihong Kuang Jialin Xu Jialin Xu Fenting Xu Fenting Xu Weizhen Huang Muhammad Majid Muhammad Majid Hui Shi Hui Shi Xia Yuan Yongdui Ruan Yongdui Ruan Yongdui Ruan Xianjing Hu Xianjing Hu Xianjing Hu Xianjing Hu |
| author_facet | Weihong Kuang Weihong Kuang Weihong Kuang Jialin Xu Jialin Xu Fenting Xu Fenting Xu Weizhen Huang Muhammad Majid Muhammad Majid Hui Shi Hui Shi Xia Yuan Yongdui Ruan Yongdui Ruan Yongdui Ruan Xianjing Hu Xianjing Hu Xianjing Hu Xianjing Hu |
| author_sort | Weihong Kuang |
| collection | DOAJ |
| description | Chronic atrophic gastritis (CAG) is a prevalent digestive system disease characterized by atrophy of the gastric mucosa and the disappearance of inherent gastric glands. According to the theory of Correa’s cascade, CAG is an important pathological stage in the transformation from normal condition to gastric carcinoma. In recent years, the global incidence of CAG has been increasing due to pathogenic factors, including Helicobacter pylori infection, bile reflux, and the consumption of processed meats. In this review, we comprehensively described the etiology and clinical diagnosis of CAG. We focused on elucidating the regulatory mechanisms and promising therapeutic targets in CAG, with the expectation of providing insights and theoretical support for future research on CAG. |
| format | Article |
| id | doaj-art-2088234c9dda4514a5f426dad404d7e4 |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-2088234c9dda4514a5f426dad404d7e42025-08-20T02:22:06ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-12-011210.3389/fcell.2024.15134261513426Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive reviewWeihong Kuang0Weihong Kuang1Weihong Kuang2Jialin Xu3Jialin Xu4Fenting Xu5Fenting Xu6Weizhen Huang7Muhammad Majid8Muhammad Majid9Hui Shi10Hui Shi11Xia Yuan12Yongdui Ruan13Yongdui Ruan14Yongdui Ruan15Xianjing Hu16Xianjing Hu17Xianjing Hu18Xianjing Hu19Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan, ChinaDongguan Key Laboratory of Traditional Chinese Medicines for Prevention and Treatment of Digestive Diseases, Guangdong Medical University, Dongguan, ChinaDongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, ChinaGuangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan, ChinaDongguan Key Laboratory of Traditional Chinese Medicines for Prevention and Treatment of Digestive Diseases, Guangdong Medical University, Dongguan, ChinaGuangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan, ChinaDongguan Key Laboratory of Traditional Chinese Medicines for Prevention and Treatment of Digestive Diseases, Guangdong Medical University, Dongguan, ChinaCancer Center, The First Huizhou Affiliated Hospital, Guangdong Medical University, Huizhou, ChinaGuangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan, ChinaDongguan Key Laboratory of Traditional Chinese Medicines for Prevention and Treatment of Digestive Diseases, Guangdong Medical University, Dongguan, ChinaGuangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan, ChinaDongguan Key Laboratory of Traditional Chinese Medicines for Prevention and Treatment of Digestive Diseases, Guangdong Medical University, Dongguan, ChinaCancer Center, The First Huizhou Affiliated Hospital, Guangdong Medical University, Huizhou, ChinaGuangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan, ChinaDongguan Key Laboratory of Traditional Chinese Medicines for Prevention and Treatment of Digestive Diseases, Guangdong Medical University, Dongguan, ChinaCancer Center, The First Huizhou Affiliated Hospital, Guangdong Medical University, Huizhou, ChinaGuangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan, ChinaDongguan Key Laboratory of Traditional Chinese Medicines for Prevention and Treatment of Digestive Diseases, Guangdong Medical University, Dongguan, ChinaDongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, ChinaDepartment of Acupuncture, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, ChinaChronic atrophic gastritis (CAG) is a prevalent digestive system disease characterized by atrophy of the gastric mucosa and the disappearance of inherent gastric glands. According to the theory of Correa’s cascade, CAG is an important pathological stage in the transformation from normal condition to gastric carcinoma. In recent years, the global incidence of CAG has been increasing due to pathogenic factors, including Helicobacter pylori infection, bile reflux, and the consumption of processed meats. In this review, we comprehensively described the etiology and clinical diagnosis of CAG. We focused on elucidating the regulatory mechanisms and promising therapeutic targets in CAG, with the expectation of providing insights and theoretical support for future research on CAG.https://www.frontiersin.org/articles/10.3389/fcell.2024.1513426/fullchronic atrophic gastritispathogenetic mechanismsgastric precancerous lesionsbiomarkerstherapeutic targets |
| spellingShingle | Weihong Kuang Weihong Kuang Weihong Kuang Jialin Xu Jialin Xu Fenting Xu Fenting Xu Weizhen Huang Muhammad Majid Muhammad Majid Hui Shi Hui Shi Xia Yuan Yongdui Ruan Yongdui Ruan Yongdui Ruan Xianjing Hu Xianjing Hu Xianjing Hu Xianjing Hu Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review Frontiers in Cell and Developmental Biology chronic atrophic gastritis pathogenetic mechanisms gastric precancerous lesions biomarkers therapeutic targets |
| title | Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review |
| title_full | Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review |
| title_fullStr | Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review |
| title_full_unstemmed | Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review |
| title_short | Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review |
| title_sort | current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis a comprehensive review |
| topic | chronic atrophic gastritis pathogenetic mechanisms gastric precancerous lesions biomarkers therapeutic targets |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1513426/full |
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