The telomere-to-telomere chromosome-scale genome assembly of Acremonium chrysogenum
Abstract Acremonium chrysogenum is a notable filamentous fungus recognized for its essential contribution to the pharmaceutical sector through the biosynthesis of cephalosporin C (CPC). CPC functions as a key intermediate in the biosynthesis of β-lactam antibiotics, which are employed to combat bact...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-025-05645-x |
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| author | Chao Han Yiping Zhang Hengyu Liang Minliang Chen Jiahuang Li Zichun Hua |
| author_facet | Chao Han Yiping Zhang Hengyu Liang Minliang Chen Jiahuang Li Zichun Hua |
| author_sort | Chao Han |
| collection | DOAJ |
| description | Abstract Acremonium chrysogenum is a notable filamentous fungus recognized for its essential contribution to the pharmaceutical sector through the biosynthesis of cephalosporin C (CPC). CPC functions as a key intermediate in the biosynthesis of β-lactam antibiotics, which are employed to combat bacterial infections. This study successfully generated a telomere-to-telomere (T2T) chromosome-scale genome sequence for A. chrysogenum, combining BGI short reads, PacBio HiFi long reads, and Hi-C technology. This genome sequence contained eight complete chromosomes (29.00 Mb) and a circular mitochondrial genome (27.27 kb), featuring an N50 length of 3.87 Mb. Repetitive elements accounted for 9.65% of genomic content, and a total of 7,745 genes involved in protein coding were annotated. This well-assembled reference genome of A. chrysogenum serves as an important foundation for elucidating the biosynthetic pathway of cephalosporin C and for molecular breeding. Furthermore, it offers valuable insights into chromosome organization, genome evolution, and regulatory mechanisms, facilitating future advancements in antibiotic research and fungal biotechnology. |
| format | Article |
| id | doaj-art-208518e080e44bcfa7c86d95d5d13726 |
| institution | DOAJ |
| issn | 2052-4463 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj-art-208518e080e44bcfa7c86d95d5d137262025-08-20T03:04:17ZengNature PortfolioScientific Data2052-44632025-08-011211810.1038/s41597-025-05645-xThe telomere-to-telomere chromosome-scale genome assembly of Acremonium chrysogenumChao Han0Yiping Zhang1Hengyu Liang2Minliang Chen3Jiahuang Li4Zichun Hua5The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing UniversityHenan Joincare Biopharma Research Institute Co. LtdHenan Joincare Biopharma Research Institute Co. LtdHenan Joincare Biopharma Research Institute Co. LtdSchool of Biopharmacy, China Pharmaceutical UniversityThe State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing UniversityAbstract Acremonium chrysogenum is a notable filamentous fungus recognized for its essential contribution to the pharmaceutical sector through the biosynthesis of cephalosporin C (CPC). CPC functions as a key intermediate in the biosynthesis of β-lactam antibiotics, which are employed to combat bacterial infections. This study successfully generated a telomere-to-telomere (T2T) chromosome-scale genome sequence for A. chrysogenum, combining BGI short reads, PacBio HiFi long reads, and Hi-C technology. This genome sequence contained eight complete chromosomes (29.00 Mb) and a circular mitochondrial genome (27.27 kb), featuring an N50 length of 3.87 Mb. Repetitive elements accounted for 9.65% of genomic content, and a total of 7,745 genes involved in protein coding were annotated. This well-assembled reference genome of A. chrysogenum serves as an important foundation for elucidating the biosynthetic pathway of cephalosporin C and for molecular breeding. Furthermore, it offers valuable insights into chromosome organization, genome evolution, and regulatory mechanisms, facilitating future advancements in antibiotic research and fungal biotechnology.https://doi.org/10.1038/s41597-025-05645-x |
| spellingShingle | Chao Han Yiping Zhang Hengyu Liang Minliang Chen Jiahuang Li Zichun Hua The telomere-to-telomere chromosome-scale genome assembly of Acremonium chrysogenum Scientific Data |
| title | The telomere-to-telomere chromosome-scale genome assembly of Acremonium chrysogenum |
| title_full | The telomere-to-telomere chromosome-scale genome assembly of Acremonium chrysogenum |
| title_fullStr | The telomere-to-telomere chromosome-scale genome assembly of Acremonium chrysogenum |
| title_full_unstemmed | The telomere-to-telomere chromosome-scale genome assembly of Acremonium chrysogenum |
| title_short | The telomere-to-telomere chromosome-scale genome assembly of Acremonium chrysogenum |
| title_sort | telomere to telomere chromosome scale genome assembly of acremonium chrysogenum |
| url | https://doi.org/10.1038/s41597-025-05645-x |
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