Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection
Worldwide morbidity and mortality from acute myocardial infarction (AMI) and related heart failure remain high. While effective early reperfusion of the criminal coronary artery after a confirmed AMI is the typical treatment at present, collateral myocardial ischemia-reperfusion injury (MIRI) and pe...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/6935147 |
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| author | Nan-Bo Liu Min Wu Chen Chen Masayuki Fujino Jing-Song Huang Ping Zhu Xiao-Kang Li |
| author_facet | Nan-Bo Liu Min Wu Chen Chen Masayuki Fujino Jing-Song Huang Ping Zhu Xiao-Kang Li |
| author_sort | Nan-Bo Liu |
| collection | DOAJ |
| description | Worldwide morbidity and mortality from acute myocardial infarction (AMI) and related heart failure remain high. While effective early reperfusion of the criminal coronary artery after a confirmed AMI is the typical treatment at present, collateral myocardial ischemia-reperfusion injury (MIRI) and pertinent cardioprotection are still challenging to address and have inadequately understood mechanisms. Therefore, unveiling the related novel molecular targets and networks participating in triggering and resisting the pathobiology of MIRI is a promising and valuable frontier. The present study specifically focuses on the recent MIRI advances that are supported by sophisticated bio-methodology in order to bring the poorly understood interrelationship among pro- and anti-MIRI participant molecules up to date, as well as to identify findings that may facilitate the further investigation of novel targets. |
| format | Article |
| id | doaj-art-2084a173fadd42c8b0b307de748c136d |
| institution | OA Journals |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-2084a173fadd42c8b0b307de748c136d2025-08-20T02:03:55ZengWileyCardiology Research and Practice2090-80162090-05972019-01-01201910.1155/2019/69351476935147Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and CardioprotectionNan-Bo Liu0Min Wu1Chen Chen2Masayuki Fujino3Jing-Song Huang4Ping Zhu5Xiao-Kang Li6Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, ChinaDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, ChinaDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, ChinaDivision of Transplantation Immunology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, ChinaDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, ChinaDivision of Transplantation Immunology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanWorldwide morbidity and mortality from acute myocardial infarction (AMI) and related heart failure remain high. While effective early reperfusion of the criminal coronary artery after a confirmed AMI is the typical treatment at present, collateral myocardial ischemia-reperfusion injury (MIRI) and pertinent cardioprotection are still challenging to address and have inadequately understood mechanisms. Therefore, unveiling the related novel molecular targets and networks participating in triggering and resisting the pathobiology of MIRI is a promising and valuable frontier. The present study specifically focuses on the recent MIRI advances that are supported by sophisticated bio-methodology in order to bring the poorly understood interrelationship among pro- and anti-MIRI participant molecules up to date, as well as to identify findings that may facilitate the further investigation of novel targets.http://dx.doi.org/10.1155/2019/6935147 |
| spellingShingle | Nan-Bo Liu Min Wu Chen Chen Masayuki Fujino Jing-Song Huang Ping Zhu Xiao-Kang Li Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection Cardiology Research and Practice |
| title | Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection |
| title_full | Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection |
| title_fullStr | Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection |
| title_full_unstemmed | Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection |
| title_short | Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection |
| title_sort | novel molecular targets participating in myocardial ischemia reperfusion injury and cardioprotection |
| url | http://dx.doi.org/10.1155/2019/6935147 |
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