Optimization of the acceleration of compressed sensing in whole-heart contrast-free coronary magnetic resonance angiography
ABSTRACT: Background: This study aims to identify optimal acceleration factors (AFs) for compressed sensing (CS) technology to enhance its clinical application for suspected coronary artery disease (CAD) in whole-heart non-contrast coronary magnetic resonance angiography (CMRA). Methods: Two hundre...
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Elsevier
2025-01-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1097664725000079 |
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| author | Weiwei Wang Longyan Zhang Guangzong Su Feng Xiong Yang Wu Ke Yu Qiaodan Yi Peng Sun |
| author_facet | Weiwei Wang Longyan Zhang Guangzong Su Feng Xiong Yang Wu Ke Yu Qiaodan Yi Peng Sun |
| author_sort | Weiwei Wang |
| collection | DOAJ |
| description | ABSTRACT: Background: This study aims to identify optimal acceleration factors (AFs) for compressed sensing (CS) technology to enhance its clinical application for suspected coronary artery disease (CAD) in whole-heart non-contrast coronary magnetic resonance angiography (CMRA). Methods: Two hundred and seventeen individuals with suspected CAD underwent whole-heart non-contrast CMRA on a 1.5T CMR scanner with CS AFs of 2, 4, and 6 (CS2, CS4, and CS6). Two radiologists independently and blindly scored the image quality. The overall image scores, coronary artery segment scores, signal-to-noise ratios (SNR), contrast-to-noise ratios (CNR), and scan times were compared. The scores for the left anterior descending coronary artery (LAD), left circumflex coronary artery (LCX), and right coronary artery (RCA) were assessed. Of the 217 patients, 37 (37/217, 17.1%) underwent x-ray coronary angiography (CAG). The images from CS2, CS4, and CS6 were evaluated by two radiologists blinded to CAG results to identify significant luminal narrowing. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. Results: The CS2 group exhibited higher overall scores, coronary artery segment scores, SNR, and CNR, but longer scan times compared to the CS4 and CS6 groups (overall score: 24.5 vs 22.0 vs 21.0, p < 0.001; SNR: 127 vs 112 vs 99, p < 0.001; CNRcor-fat: 118 vs 101 vs 84, p < 0.001; CNRcor-myo: 69.7 vs 62.8 vs 53.5, p < 0.001; scan time: 884 ± 308 s vs 473 ± 163 s vs 331 ± 146 s, p < 0.001). Proximal and middle segments received higher scores compared to their corresponding distal segments, and the RCA exhibited higher image quality than LAD and LCX in all groups (p < 0.05). In the subgroup analysis, 19 (19/37, 51.3%) were diagnosed with CAD by CAG. The sensitivity, specificity, PPV, NPV, and accuracy were as follows: CS2 (94.7%, 88.9%, 90.0%, 94.1%, and 91.9%), CS4 (89.5%, 94.4%, 94.4%, 89.5%, and 91.9%), and CS6 (89.5%, 66.7%, 73.9%, 85.7%, and 78.4%), respectively, in patient-based analysis. Conclusion: Image quality showed a decreasing trend with increasing CS AFs, while scan time decreased in non-contrast CMRA. A scanning protocol using CS4 provided high-quality images with relatively short scan times and showed potential for detecting significant coronary stenosis, making it an optimal protocol for coronary magnetic resonance imaging. |
| format | Article |
| id | doaj-art-2083c30545af43499763a8c6a3cd98b1 |
| institution | OA Journals |
| issn | 1097-6647 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj-art-2083c30545af43499763a8c6a3cd98b12025-08-20T02:08:46ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66472025-01-0127110184510.1016/j.jocmr.2025.101845Optimization of the acceleration of compressed sensing in whole-heart contrast-free coronary magnetic resonance angiographyWeiwei Wang0Longyan Zhang1Guangzong Su2Feng Xiong3Yang Wu4Ke Yu5Qiaodan Yi6Peng Sun7Department of Magnetic Resonance Imaging, Wuhan Asia General Hospital, Wuhan, ChinaDepartment of Magnetic Resonance Imaging, Wuhan Asia General Hospital, Wuhan, ChinaDepartment of Magnetic Resonance Imaging, Wuhan Asia General Hospital, Wuhan, ChinaDepartment of Magnetic Resonance Imaging, Wuhan Asia General Hospital, Wuhan, ChinaDepartment of Magnetic Resonance Imaging, Wuhan Asia General Hospital, Wuhan, China; Corresponding author.Department of Magnetic Resonance Imaging, Wuhan Asia General Hospital, Wuhan, ChinaDepartment of Magnetic Resonance Imaging, Wuhan Asia General Hospital, Wuhan, ChinaPhilips Healthcare, Beijing, ChinaABSTRACT: Background: This study aims to identify optimal acceleration factors (AFs) for compressed sensing (CS) technology to enhance its clinical application for suspected coronary artery disease (CAD) in whole-heart non-contrast coronary magnetic resonance angiography (CMRA). Methods: Two hundred and seventeen individuals with suspected CAD underwent whole-heart non-contrast CMRA on a 1.5T CMR scanner with CS AFs of 2, 4, and 6 (CS2, CS4, and CS6). Two radiologists independently and blindly scored the image quality. The overall image scores, coronary artery segment scores, signal-to-noise ratios (SNR), contrast-to-noise ratios (CNR), and scan times were compared. The scores for the left anterior descending coronary artery (LAD), left circumflex coronary artery (LCX), and right coronary artery (RCA) were assessed. Of the 217 patients, 37 (37/217, 17.1%) underwent x-ray coronary angiography (CAG). The images from CS2, CS4, and CS6 were evaluated by two radiologists blinded to CAG results to identify significant luminal narrowing. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. Results: The CS2 group exhibited higher overall scores, coronary artery segment scores, SNR, and CNR, but longer scan times compared to the CS4 and CS6 groups (overall score: 24.5 vs 22.0 vs 21.0, p < 0.001; SNR: 127 vs 112 vs 99, p < 0.001; CNRcor-fat: 118 vs 101 vs 84, p < 0.001; CNRcor-myo: 69.7 vs 62.8 vs 53.5, p < 0.001; scan time: 884 ± 308 s vs 473 ± 163 s vs 331 ± 146 s, p < 0.001). Proximal and middle segments received higher scores compared to their corresponding distal segments, and the RCA exhibited higher image quality than LAD and LCX in all groups (p < 0.05). In the subgroup analysis, 19 (19/37, 51.3%) were diagnosed with CAD by CAG. The sensitivity, specificity, PPV, NPV, and accuracy were as follows: CS2 (94.7%, 88.9%, 90.0%, 94.1%, and 91.9%), CS4 (89.5%, 94.4%, 94.4%, 89.5%, and 91.9%), and CS6 (89.5%, 66.7%, 73.9%, 85.7%, and 78.4%), respectively, in patient-based analysis. Conclusion: Image quality showed a decreasing trend with increasing CS AFs, while scan time decreased in non-contrast CMRA. A scanning protocol using CS4 provided high-quality images with relatively short scan times and showed potential for detecting significant coronary stenosis, making it an optimal protocol for coronary magnetic resonance imaging.http://www.sciencedirect.com/science/article/pii/S1097664725000079Acceleration factorCompressed sensingCoronary magnetic resonance angiographyScan timeImage quality |
| spellingShingle | Weiwei Wang Longyan Zhang Guangzong Su Feng Xiong Yang Wu Ke Yu Qiaodan Yi Peng Sun Optimization of the acceleration of compressed sensing in whole-heart contrast-free coronary magnetic resonance angiography Journal of Cardiovascular Magnetic Resonance Acceleration factor Compressed sensing Coronary magnetic resonance angiography Scan time Image quality |
| title | Optimization of the acceleration of compressed sensing in whole-heart contrast-free coronary magnetic resonance angiography |
| title_full | Optimization of the acceleration of compressed sensing in whole-heart contrast-free coronary magnetic resonance angiography |
| title_fullStr | Optimization of the acceleration of compressed sensing in whole-heart contrast-free coronary magnetic resonance angiography |
| title_full_unstemmed | Optimization of the acceleration of compressed sensing in whole-heart contrast-free coronary magnetic resonance angiography |
| title_short | Optimization of the acceleration of compressed sensing in whole-heart contrast-free coronary magnetic resonance angiography |
| title_sort | optimization of the acceleration of compressed sensing in whole heart contrast free coronary magnetic resonance angiography |
| topic | Acceleration factor Compressed sensing Coronary magnetic resonance angiography Scan time Image quality |
| url | http://www.sciencedirect.com/science/article/pii/S1097664725000079 |
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