Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity
The mammalian intestine harbors a remarkable number of microbes and their components and metabolites, which are fundamental for the instigation and development of the host immune system. The intestinal innate and adaptive immunity coordinate and interact with the symbionts contributing to the intest...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/4735040 |
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| author | Li Wang Limeng Zhu Song Qin |
| author_facet | Li Wang Limeng Zhu Song Qin |
| author_sort | Li Wang |
| collection | DOAJ |
| description | The mammalian intestine harbors a remarkable number of microbes and their components and metabolites, which are fundamental for the instigation and development of the host immune system. The intestinal innate and adaptive immunity coordinate and interact with the symbionts contributing to the intestinal homeostasis through establishment of a mutually beneficial relationship by tolerating to symbiotic microbiota and retaining the ability to exert proinflammatory response towards invasive pathogens. Imbalance between the intestinal immune system and commensal organisms disrupts the intestinal microbiological homeostasis, leading to microbiota dysbiosis, compromised integrity of the intestinal barrier, and proinflammatory immune responses towards symbionts. This, in turn, exacerbates the degree of the imbalance. Intestinal adaptive immunity plays a critical role in maintaining immune tolerance towards symbionts and the integrity of intestinal barrier, while the innate immune system regulates the adaptive immune responses to intestinal commensal bacteria. In this review, we will summarize recent findings on the effects and mechanisms of gut microbiota on intestinal adaptive immunity and the plasticity of several immune cells under diverse microenvironmental settings. |
| format | Article |
| id | doaj-art-20831e70b5aa4ff3845f23be9cbea7a4 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-20831e70b5aa4ff3845f23be9cbea7a42025-08-20T02:03:55ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/47350404735040Gut Microbiota Modulation on Intestinal Mucosal Adaptive ImmunityLi Wang0Limeng Zhu1Song Qin2Hepatology Department, Infectious Disease Hospital of Yantai, 62 Huanshan Road, Zhifu District, Yantai 264001, ChinaInstitute of Processing Engineering, University of Chinese Academy of Sciences, 1 North 2nd Street, Zhongguancun, Haidian District, Beijing 100049, ChinaYantai Institute of Costal Zone Research, Chinese Academy of Sciences, 17 Chunhui Road, Laishan District, Yantai 264003, ChinaThe mammalian intestine harbors a remarkable number of microbes and their components and metabolites, which are fundamental for the instigation and development of the host immune system. The intestinal innate and adaptive immunity coordinate and interact with the symbionts contributing to the intestinal homeostasis through establishment of a mutually beneficial relationship by tolerating to symbiotic microbiota and retaining the ability to exert proinflammatory response towards invasive pathogens. Imbalance between the intestinal immune system and commensal organisms disrupts the intestinal microbiological homeostasis, leading to microbiota dysbiosis, compromised integrity of the intestinal barrier, and proinflammatory immune responses towards symbionts. This, in turn, exacerbates the degree of the imbalance. Intestinal adaptive immunity plays a critical role in maintaining immune tolerance towards symbionts and the integrity of intestinal barrier, while the innate immune system regulates the adaptive immune responses to intestinal commensal bacteria. In this review, we will summarize recent findings on the effects and mechanisms of gut microbiota on intestinal adaptive immunity and the plasticity of several immune cells under diverse microenvironmental settings.http://dx.doi.org/10.1155/2019/4735040 |
| spellingShingle | Li Wang Limeng Zhu Song Qin Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity Journal of Immunology Research |
| title | Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity |
| title_full | Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity |
| title_fullStr | Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity |
| title_full_unstemmed | Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity |
| title_short | Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity |
| title_sort | gut microbiota modulation on intestinal mucosal adaptive immunity |
| url | http://dx.doi.org/10.1155/2019/4735040 |
| work_keys_str_mv | AT liwang gutmicrobiotamodulationonintestinalmucosaladaptiveimmunity AT limengzhu gutmicrobiotamodulationonintestinalmucosaladaptiveimmunity AT songqin gutmicrobiotamodulationonintestinalmucosaladaptiveimmunity |