A Hypothesis: Hydrogen Sulfide Might Be Neuroprotective against Subarachnoid Hemorrhage Induced Brain Injury
Gases such as nitric oxide (NO) and carbon monoxide (CO) play important roles both in normal physiology and in disease. Recent studies have shown that hydrogen sulfide (H2S) protects neurons against oxidative stress and ischemia-reperfusion injury and attenuates lipopolysaccharides (LPS) induced neu...
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| Format: | Article |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/432318 |
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| author | Yong-Peng Yu Xiang-Lin Chi Li-Jun Liu |
| author_facet | Yong-Peng Yu Xiang-Lin Chi Li-Jun Liu |
| author_sort | Yong-Peng Yu |
| collection | DOAJ |
| description | Gases such as nitric oxide (NO) and carbon monoxide (CO) play important roles both in normal physiology and in disease. Recent studies have shown that hydrogen sulfide (H2S) protects neurons against oxidative stress and ischemia-reperfusion injury and attenuates lipopolysaccharides (LPS) induced neuroinflammation in microglia, exhibiting anti-inflammatory and antiapoptotic activities. The gas H2S is emerging as a novel regulator of important physiologic functions such as arterial diameter, blood flow, and leukocyte adhesion. It has been known that multiple factors, including oxidative stress, free radicals, and neuronal nitric oxide synthesis as well as abnormal inflammatory responses, are involved in the mechanism underlying the brain injury after subarachnoid hemorrhage (SAH). Based on the multiple physiologic functions of H2S, we speculate that it might be a promising, effective, and specific therapy for brain injury after SAH. |
| format | Article |
| id | doaj-art-2082f2df8d2741e7a1ce4cce05d177d4 |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-2082f2df8d2741e7a1ce4cce05d177d42025-08-20T02:03:55ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/432318432318A Hypothesis: Hydrogen Sulfide Might Be Neuroprotective against Subarachnoid Hemorrhage Induced Brain InjuryYong-Peng Yu0Xiang-Lin Chi1Li-Jun Liu2Department of Neurology, Wendeng Center Hospital of Weihai, The Affiliated Hospital of Weifang Medical College, Weihai 264400, ChinaDepartment of Neurology, Wendeng Center Hospital of Weihai, The Affiliated Hospital of Weifang Medical College, Weihai 264400, ChinaDepartment of Neurology, The Affiliated Hospital of the Medical College of Qingdao University, Shandong 266003, ChinaGases such as nitric oxide (NO) and carbon monoxide (CO) play important roles both in normal physiology and in disease. Recent studies have shown that hydrogen sulfide (H2S) protects neurons against oxidative stress and ischemia-reperfusion injury and attenuates lipopolysaccharides (LPS) induced neuroinflammation in microglia, exhibiting anti-inflammatory and antiapoptotic activities. The gas H2S is emerging as a novel regulator of important physiologic functions such as arterial diameter, blood flow, and leukocyte adhesion. It has been known that multiple factors, including oxidative stress, free radicals, and neuronal nitric oxide synthesis as well as abnormal inflammatory responses, are involved in the mechanism underlying the brain injury after subarachnoid hemorrhage (SAH). Based on the multiple physiologic functions of H2S, we speculate that it might be a promising, effective, and specific therapy for brain injury after SAH.http://dx.doi.org/10.1155/2014/432318 |
| spellingShingle | Yong-Peng Yu Xiang-Lin Chi Li-Jun Liu A Hypothesis: Hydrogen Sulfide Might Be Neuroprotective against Subarachnoid Hemorrhage Induced Brain Injury The Scientific World Journal |
| title | A Hypothesis: Hydrogen Sulfide Might Be Neuroprotective against Subarachnoid Hemorrhage Induced Brain Injury |
| title_full | A Hypothesis: Hydrogen Sulfide Might Be Neuroprotective against Subarachnoid Hemorrhage Induced Brain Injury |
| title_fullStr | A Hypothesis: Hydrogen Sulfide Might Be Neuroprotective against Subarachnoid Hemorrhage Induced Brain Injury |
| title_full_unstemmed | A Hypothesis: Hydrogen Sulfide Might Be Neuroprotective against Subarachnoid Hemorrhage Induced Brain Injury |
| title_short | A Hypothesis: Hydrogen Sulfide Might Be Neuroprotective against Subarachnoid Hemorrhage Induced Brain Injury |
| title_sort | hypothesis hydrogen sulfide might be neuroprotective against subarachnoid hemorrhage induced brain injury |
| url | http://dx.doi.org/10.1155/2014/432318 |
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