Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01
Abstract Two new cytochalasans, xylariaides A (1) and B (2), were isolated and identified from a soil fungus Xylaria sp. Y01. Their structures were unambiguously determined by extensive spectroscopic methods including high resolution electrospray ionization mass spectrometry, ultraviolet radiation,...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-04-01
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| Series: | Natural Products and Bioprospecting |
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| Online Access: | https://doi.org/10.1007/s13659-025-00507-w |
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| author | Yi-Yun Yuan Yan Li Wen-Yu Lu Ai-Lin Liang Jing Li Wen-Xuan Wang |
| author_facet | Yi-Yun Yuan Yan Li Wen-Yu Lu Ai-Lin Liang Jing Li Wen-Xuan Wang |
| author_sort | Yi-Yun Yuan |
| collection | DOAJ |
| description | Abstract Two new cytochalasans, xylariaides A (1) and B (2), were isolated and identified from a soil fungus Xylaria sp. Y01. Their structures were unambiguously determined by extensive spectroscopic methods including high resolution electrospray ionization mass spectrometry, ultraviolet radiation, infrared spectroscopy, and 1D/2D NMR, as well as in-depth quantum chemical calculations of gauge-including atomic orbital (GIAO) 13C NMR chemical shifts, electronic circular dichroism (ECD), and spin–spin coupling constants. The unprecedented core structure with a 5/6/5/3 fused tetracyclic ring system further enriches the scaffold types of cytochalasans. Graphical Abstract |
| format | Article |
| id | doaj-art-2081d6e514ec429782749c56a8553cd6 |
| institution | DOAJ |
| issn | 2192-2195 2192-2209 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj-art-2081d6e514ec429782749c56a8553cd62025-08-20T03:10:16ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092025-04-0115111110.1007/s13659-025-00507-wXylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01Yi-Yun Yuan0Yan Li1Wen-Yu Lu2Ai-Lin Liang3Jing Li4Wen-Xuan Wang5Xiangya School of Pharmaceutical Sciences, Central South UniversityXiangya School of Pharmaceutical Sciences, Central South UniversityXiangya School of Pharmaceutical Sciences, Central South UniversityXiangya School of Pharmaceutical Sciences, Central South UniversityXiangya School of Pharmaceutical Sciences, Central South UniversityXiangya School of Pharmaceutical Sciences, Central South UniversityAbstract Two new cytochalasans, xylariaides A (1) and B (2), were isolated and identified from a soil fungus Xylaria sp. Y01. Their structures were unambiguously determined by extensive spectroscopic methods including high resolution electrospray ionization mass spectrometry, ultraviolet radiation, infrared spectroscopy, and 1D/2D NMR, as well as in-depth quantum chemical calculations of gauge-including atomic orbital (GIAO) 13C NMR chemical shifts, electronic circular dichroism (ECD), and spin–spin coupling constants. The unprecedented core structure with a 5/6/5/3 fused tetracyclic ring system further enriches the scaffold types of cytochalasans. Graphical Abstracthttps://doi.org/10.1007/s13659-025-00507-wCytochalasinsXylaria sp.Coupling constant calculationECD calculationGIAO 13C NMR calculation |
| spellingShingle | Yi-Yun Yuan Yan Li Wen-Yu Lu Ai-Lin Liang Jing Li Wen-Xuan Wang Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01 Natural Products and Bioprospecting Cytochalasins Xylaria sp. Coupling constant calculation ECD calculation GIAO 13C NMR calculation |
| title | Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01 |
| title_full | Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01 |
| title_fullStr | Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01 |
| title_full_unstemmed | Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01 |
| title_short | Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01 |
| title_sort | xylariaides a and b novel cytochalasans with a unique 5 6 5 3 ring system from a soil fungus xylaria sp y01 |
| topic | Cytochalasins Xylaria sp. Coupling constant calculation ECD calculation GIAO 13C NMR calculation |
| url | https://doi.org/10.1007/s13659-025-00507-w |
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