Utility and clinical significance of endoscopic ultrasound-guided tissue acquisition for diagnosing lymphadenopathies in biliary tract cancer
Abstract Lymph node sampling with endoscopic ultrasound fine needle aspiration (EUS-FNA) may affect treatment options for biliary tract cancers. Our aim is to clarify its utility and clinical significance and the factors associated with FNA cytology positivity. Seventy-one consecutive patients with...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-87473-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571707902132224 |
|---|---|
| author | Katsuhiko Sato Minoru Shigekawa Syuhei Yamamoto Takayuki Matsumae Yu Sato Teppei Yoshioka Takahiro Kodama Hayato Hikita Tomohide Tatsumi Tetsuo Takehara |
| author_facet | Katsuhiko Sato Minoru Shigekawa Syuhei Yamamoto Takayuki Matsumae Yu Sato Teppei Yoshioka Takahiro Kodama Hayato Hikita Tomohide Tatsumi Tetsuo Takehara |
| author_sort | Katsuhiko Sato |
| collection | DOAJ |
| description | Abstract Lymph node sampling with endoscopic ultrasound fine needle aspiration (EUS-FNA) may affect treatment options for biliary tract cancers. Our aim is to clarify its utility and clinical significance and the factors associated with FNA cytology positivity. Seventy-one consecutive patients with biliary tract cancer who underwent EUS-FNA to diagnose lymphadenopathies from April 2012 to July 2021 were enrolled retrospectively. Lymph nodes with a short diameter over 10 mm and/or fluorodeoxyglucose uptake were considered FNA targets. Samples eligible for cytology were attained in 70 patients with no complications. The FNA cytology-positive rate was 54%. In 35 patients with difficulty in obtaining pathological proof from primary tumors, obtaining a pathological diagnosis was successful in 24 patients. Thirteen of 16 FNA cytology-positive patients who were diagnosed with preoperative regional lymph node metastasis received chemotherapy prior to surgery. All seven FNA cytology-positive patients who were diagnosed with distant metastasis received systemic chemotherapy. Multivariate analyses showed a neutrophil-to-lymphocyte ratio over 2.5 (odds ratio (OR) 4.69, p = 0.04), fluorodeoxyglucose uptake (OR 5.34, p = 0.014), and a short diameter over 10.6 mm (OR 6.11, p = 0.018) as factors related to FNA cytology positivity. EUS-FNA of lymphadenopathies in biliary tract cancers may affect clinical biliary tract cancer strategies. |
| format | Article |
| id | doaj-art-2080580489fe4079a491b3278c1b886c |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-2080580489fe4079a491b3278c1b886c2025-02-02T12:23:38ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-87473-yUtility and clinical significance of endoscopic ultrasound-guided tissue acquisition for diagnosing lymphadenopathies in biliary tract cancerKatsuhiko Sato0Minoru Shigekawa1Syuhei Yamamoto2Takayuki Matsumae3Yu Sato4Teppei Yoshioka5Takahiro Kodama6Hayato Hikita7Tomohide Tatsumi8Tetsuo Takehara9Department of Gastroenterology and Hepatology, Osaka University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Osaka University Graduate School of MedicineAbstract Lymph node sampling with endoscopic ultrasound fine needle aspiration (EUS-FNA) may affect treatment options for biliary tract cancers. Our aim is to clarify its utility and clinical significance and the factors associated with FNA cytology positivity. Seventy-one consecutive patients with biliary tract cancer who underwent EUS-FNA to diagnose lymphadenopathies from April 2012 to July 2021 were enrolled retrospectively. Lymph nodes with a short diameter over 10 mm and/or fluorodeoxyglucose uptake were considered FNA targets. Samples eligible for cytology were attained in 70 patients with no complications. The FNA cytology-positive rate was 54%. In 35 patients with difficulty in obtaining pathological proof from primary tumors, obtaining a pathological diagnosis was successful in 24 patients. Thirteen of 16 FNA cytology-positive patients who were diagnosed with preoperative regional lymph node metastasis received chemotherapy prior to surgery. All seven FNA cytology-positive patients who were diagnosed with distant metastasis received systemic chemotherapy. Multivariate analyses showed a neutrophil-to-lymphocyte ratio over 2.5 (odds ratio (OR) 4.69, p = 0.04), fluorodeoxyglucose uptake (OR 5.34, p = 0.014), and a short diameter over 10.6 mm (OR 6.11, p = 0.018) as factors related to FNA cytology positivity. EUS-FNA of lymphadenopathies in biliary tract cancers may affect clinical biliary tract cancer strategies.https://doi.org/10.1038/s41598-025-87473-y |
| spellingShingle | Katsuhiko Sato Minoru Shigekawa Syuhei Yamamoto Takayuki Matsumae Yu Sato Teppei Yoshioka Takahiro Kodama Hayato Hikita Tomohide Tatsumi Tetsuo Takehara Utility and clinical significance of endoscopic ultrasound-guided tissue acquisition for diagnosing lymphadenopathies in biliary tract cancer Scientific Reports |
| title | Utility and clinical significance of endoscopic ultrasound-guided tissue acquisition for diagnosing lymphadenopathies in biliary tract cancer |
| title_full | Utility and clinical significance of endoscopic ultrasound-guided tissue acquisition for diagnosing lymphadenopathies in biliary tract cancer |
| title_fullStr | Utility and clinical significance of endoscopic ultrasound-guided tissue acquisition for diagnosing lymphadenopathies in biliary tract cancer |
| title_full_unstemmed | Utility and clinical significance of endoscopic ultrasound-guided tissue acquisition for diagnosing lymphadenopathies in biliary tract cancer |
| title_short | Utility and clinical significance of endoscopic ultrasound-guided tissue acquisition for diagnosing lymphadenopathies in biliary tract cancer |
| title_sort | utility and clinical significance of endoscopic ultrasound guided tissue acquisition for diagnosing lymphadenopathies in biliary tract cancer |
| url | https://doi.org/10.1038/s41598-025-87473-y |
| work_keys_str_mv | AT katsuhikosato utilityandclinicalsignificanceofendoscopicultrasoundguidedtissueacquisitionfordiagnosinglymphadenopathiesinbiliarytractcancer AT minorushigekawa utilityandclinicalsignificanceofendoscopicultrasoundguidedtissueacquisitionfordiagnosinglymphadenopathiesinbiliarytractcancer AT syuheiyamamoto utilityandclinicalsignificanceofendoscopicultrasoundguidedtissueacquisitionfordiagnosinglymphadenopathiesinbiliarytractcancer AT takayukimatsumae utilityandclinicalsignificanceofendoscopicultrasoundguidedtissueacquisitionfordiagnosinglymphadenopathiesinbiliarytractcancer AT yusato utilityandclinicalsignificanceofendoscopicultrasoundguidedtissueacquisitionfordiagnosinglymphadenopathiesinbiliarytractcancer AT teppeiyoshioka utilityandclinicalsignificanceofendoscopicultrasoundguidedtissueacquisitionfordiagnosinglymphadenopathiesinbiliarytractcancer AT takahirokodama utilityandclinicalsignificanceofendoscopicultrasoundguidedtissueacquisitionfordiagnosinglymphadenopathiesinbiliarytractcancer AT hayatohikita utilityandclinicalsignificanceofendoscopicultrasoundguidedtissueacquisitionfordiagnosinglymphadenopathiesinbiliarytractcancer AT tomohidetatsumi utilityandclinicalsignificanceofendoscopicultrasoundguidedtissueacquisitionfordiagnosinglymphadenopathiesinbiliarytractcancer AT tetsuotakehara utilityandclinicalsignificanceofendoscopicultrasoundguidedtissueacquisitionfordiagnosinglymphadenopathiesinbiliarytractcancer |