Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in women of reproductive age. It has a strong hereditary component estimated at 60 to 70% in daughters. It has been suggested that environmental factors during the fetal period may be involved in the development of...
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Académie des sciences
2024-04-01
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| Series: | Comptes Rendus Biologies |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.147/ |
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| author | Mimouni, Nour El Houda Giacobini, Paolo |
| author_facet | Mimouni, Nour El Houda Giacobini, Paolo |
| author_sort | Mimouni, Nour El Houda |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in women of reproductive age. It has a strong hereditary component estimated at 60 to 70% in daughters. It has been suggested that environmental factors during the fetal period may be involved in the development of the syndrome in adulthood. However, the underlying mechanisms of its transmission remain unknown, thus limiting the development of effective therapeutic strategies.This article highlights how an altered fetal environment (prenatal exposure to high levels of anti-Müllerian hormone) can contribute to the onset of PCOS in adulthood and lead to the transgenerational transmission of neuroendocrine and metabolic traits through alterations in the DNA methylation process.The originality of the translational findings summarized here involves the identification of potential biomarkers for early diagnosis of the syndrome, in addition to the validation of a promising therapeutic avenue in a preclinical model of PCOS, which can improve the management of patients suffering from the syndrome. |
| format | Article |
| id | doaj-art-207c0e8d37ca483dbd1800d4db3cb8fd |
| institution | Kabale University |
| issn | 1768-3238 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj-art-207c0e8d37ca483dbd1800d4db3cb8fd2025-02-07T10:37:47ZengAcadémie des sciencesComptes Rendus Biologies1768-32382024-04-01347G1192510.5802/crbiol.14710.5802/crbiol.147Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndromeMimouni, Nour El Houda0https://orcid.org/0000-0001-8471-8551Giacobini, Paolo1https://orcid.org/0000-0002-3075-1441Mortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, NY, 10027, USA; Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Postnatal Brain, Lille Neuroscience & Cognition, UMR-S1172, FHU 1000 days for health, 59000 Lille, FranceUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Postnatal Brain, Lille Neuroscience & Cognition, UMR-S1172, FHU 1000 days for health, 59000 Lille, FrancePolycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in women of reproductive age. It has a strong hereditary component estimated at 60 to 70% in daughters. It has been suggested that environmental factors during the fetal period may be involved in the development of the syndrome in adulthood. However, the underlying mechanisms of its transmission remain unknown, thus limiting the development of effective therapeutic strategies.This article highlights how an altered fetal environment (prenatal exposure to high levels of anti-Müllerian hormone) can contribute to the onset of PCOS in adulthood and lead to the transgenerational transmission of neuroendocrine and metabolic traits through alterations in the DNA methylation process.The originality of the translational findings summarized here involves the identification of potential biomarkers for early diagnosis of the syndrome, in addition to the validation of a promising therapeutic avenue in a preclinical model of PCOS, which can improve the management of patients suffering from the syndrome.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.147/PCOSAMHFetal programmingHeritabilityBiomarkersEpigeneticsNeuroendocrinology |
| spellingShingle | Mimouni, Nour El Houda Giacobini, Paolo Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome Comptes Rendus Biologies PCOS AMH Fetal programming Heritability Biomarkers Epigenetics Neuroendocrinology |
| title | Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome |
| title_full | Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome |
| title_fullStr | Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome |
| title_full_unstemmed | Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome |
| title_short | Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome |
| title_sort | polycystic ovary syndrome pcos progress towards a better understanding and treatment of the syndrome |
| topic | PCOS AMH Fetal programming Heritability Biomarkers Epigenetics Neuroendocrinology |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.147/ |
| work_keys_str_mv | AT mimouninourelhouda polycysticovarysyndromepcosprogresstowardsabetterunderstandingandtreatmentofthesyndrome AT giacobinipaolo polycysticovarysyndromepcosprogresstowardsabetterunderstandingandtreatmentofthesyndrome |