Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings
Objective. To determine the association between COVID-19 infection and peripancreatic changes on CT as a sign of acute pancreatic injury. Methods. Retrospective analysis of CT examinations in patients with confirmed COVID-19 infection yielded 103 instances. An age- and gender-matched cohort of patie...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/5390337 |
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| author | Gabriela Grusova Radan Bruha Bianka Bircakova Matej Novak Lukas Lambert Pavel Michalek Grus Tomas Andrea Burgetova |
| author_facet | Gabriela Grusova Radan Bruha Bianka Bircakova Matej Novak Lukas Lambert Pavel Michalek Grus Tomas Andrea Burgetova |
| author_sort | Gabriela Grusova |
| collection | DOAJ |
| description | Objective. To determine the association between COVID-19 infection and peripancreatic changes on CT as a sign of acute pancreatic injury. Methods. Retrospective analysis of CT examinations in patients with confirmed COVID-19 infection yielded 103 instances. An age- and gender-matched cohort of patients without COVID-19 was found. CT examinations were evaluated for peripancreatic stranding or edema, fluid collection, or necrosis, without any other explanation. Depicted pulmonary parenchyma was evaluated for possible COVID-19-related changes. Clinical and laboratory data were retrieved from the clinical database. Results. Peripancreatic fat stranding (n=8) or fluid collection (n=2) without any other cause was found in 10 (10%) patients. Abdominal complaints were reported in 4 (40%) patients. Elevated serum amylase or lipase levels were documented in 5 (50%) patients who also satisfied the diagnostic criteria for acute pancreatitis. From the study sample of 103 patients with COVID-19, pulmonary parenchyma was depicted in 102 (99%), and from these, 57 (55%) had an evidence of pulmonary changes compatible with COVID-19 pneumonia. This proportion was not significantly different between patients with and without peripancreatic changes (p=0.35). In the matched cohort, we found peripancreatic changes in 2 (2%, p=0.033) patients. Patients with pancreatic injury and elevated amylase levels were more likely to require orotracheal intubation (35% vs. 12%, p=0.021). Conclusions. We showed that the prevalence of peripancreatic stranding or fluid collection is higher in patients diagnosed with COVID-19 infection compared to an age- and gender-matched cohort. Patients with pancreatic injury and elevated amylase levels are more likely to require orotracheal intubation. Our findings corroborate the link between COVID-19 infection and pancreatic injury from the perspective of imaging. |
| format | Article |
| id | doaj-art-207ba762220a449786b131b6b61ebdf0 |
| institution | Kabale University |
| issn | 1687-630X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-207ba762220a449786b131b6b61ebdf02025-08-20T03:54:43ZengWileyGastroenterology Research and Practice1687-630X2021-01-01202110.1155/2021/5390337Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT FindingsGabriela Grusova0Radan Bruha1Bianka Bircakova2Matej Novak3Lukas Lambert4Pavel Michalek5Grus Tomas6Andrea Burgetova74th Department of Internal Medicine4th Department of Internal MedicineDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of Anesthesiology and Intensive Care2nd Department of Surgery-Department of Cardiovascular SurgeryDepartment of RadiologyObjective. To determine the association between COVID-19 infection and peripancreatic changes on CT as a sign of acute pancreatic injury. Methods. Retrospective analysis of CT examinations in patients with confirmed COVID-19 infection yielded 103 instances. An age- and gender-matched cohort of patients without COVID-19 was found. CT examinations were evaluated for peripancreatic stranding or edema, fluid collection, or necrosis, without any other explanation. Depicted pulmonary parenchyma was evaluated for possible COVID-19-related changes. Clinical and laboratory data were retrieved from the clinical database. Results. Peripancreatic fat stranding (n=8) or fluid collection (n=2) without any other cause was found in 10 (10%) patients. Abdominal complaints were reported in 4 (40%) patients. Elevated serum amylase or lipase levels were documented in 5 (50%) patients who also satisfied the diagnostic criteria for acute pancreatitis. From the study sample of 103 patients with COVID-19, pulmonary parenchyma was depicted in 102 (99%), and from these, 57 (55%) had an evidence of pulmonary changes compatible with COVID-19 pneumonia. This proportion was not significantly different between patients with and without peripancreatic changes (p=0.35). In the matched cohort, we found peripancreatic changes in 2 (2%, p=0.033) patients. Patients with pancreatic injury and elevated amylase levels were more likely to require orotracheal intubation (35% vs. 12%, p=0.021). Conclusions. We showed that the prevalence of peripancreatic stranding or fluid collection is higher in patients diagnosed with COVID-19 infection compared to an age- and gender-matched cohort. Patients with pancreatic injury and elevated amylase levels are more likely to require orotracheal intubation. Our findings corroborate the link between COVID-19 infection and pancreatic injury from the perspective of imaging.http://dx.doi.org/10.1155/2021/5390337 |
| spellingShingle | Gabriela Grusova Radan Bruha Bianka Bircakova Matej Novak Lukas Lambert Pavel Michalek Grus Tomas Andrea Burgetova Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings Gastroenterology Research and Practice |
| title | Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings |
| title_full | Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings |
| title_fullStr | Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings |
| title_full_unstemmed | Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings |
| title_short | Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings |
| title_sort | pancreatic injury in patients with sars cov 2 covid 19 infection a retrospective analysis of ct findings |
| url | http://dx.doi.org/10.1155/2021/5390337 |
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