Parvovirus B19 NS1 protein induces synovitis mimicking rheumatoid arthritis

Parvovirus B19 NS1 protein induces synovitis mimicking rheumatoid arthritis

Abstract This study aims to investigate the role of parvovirus B19 infection in the pathogenesis of rheumatoid arthritis (RA). B19-NS1 DNA was cloned into the LentiORF pLEX-MCS vector, then co-transfected with the pLEX-MCS-NS1 vector and packaging system to produce LEX-NS1 lentiviral stock. LEX was...

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Bibliographic Details
Main Authors: Chang-Yi Yen, Chia-Chun Tseng, Chia‐Hui Lin, Yuan‐Zhao Lin, Ruei‐Nian Li, Pin-Yi Wang, Kuan-Yu Chen, Cheng-Chin Wu, Tsan-Teng Ou, Chung-Jen Chen, Yu-Peng Liu, Jeng-Hsien Yen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Parvovirus B19
Rheumatoid arthritis
Synovitis
RNA-seq
Online Access:https://doi.org/10.1038/s41598-025-11900-3
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