Structural basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex

Structural basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex

Abstract Type I-E CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-associated proteins) system is one of the most extensively studied RNA-guided adaptive immune systems in prokaryotes, providing defense against foreign genetic elements. Unlike the previously characteriz...

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Bibliographic Details
Main Authors: Yanan Liu, Lin Wang, Qian Zhang, Pengyu Fu, Lingling Zhang, Ying Yu, Heng Zhang, Hongtao Zhu
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55716-7
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