Relative efficacy of anti-Plasmodium vivax malaria combination drugs in preventing transmission to two major Anopheles mosquitoes in the first few days of treatment
Objectives: The World Health Organization recommends three drug anti-malarial combinations: cloroquine+primaquine, artesiminin+primaquine, and cloroquine+tafenoquine. These combinations aim to eradicate Plasmodium by disrupting its life cycle within the human body. We evaluated the effect of these m...
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Elsevier
2025-01-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224003734 |
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| author | Erika Gómez Martinez Rodrigo Maciel Alencar Rosa Amélia Gonçalves Santana Laila Rowena Albuquerque Barbosa Anne Cristine Gomes de Almeida Victor Irungu Mwangi Sarah Regiane do Nascimento Rocha Layne Even Borges de Souza Lucyane Mendes Silva Yudi Tatiana Pinilla Norbert Becker Wuelton Marcelo Monteiro Marcus Vinicius Guimarães de Lacerda Tainá Silva Secundino Raquel Soares Maia Godoy Nilton Barnabé Rodrigues Nágila Francinete Costa Secundino Gisely Cardoso de Melo Paulo Filemon Paolucci Pimenta |
| author_facet | Erika Gómez Martinez Rodrigo Maciel Alencar Rosa Amélia Gonçalves Santana Laila Rowena Albuquerque Barbosa Anne Cristine Gomes de Almeida Victor Irungu Mwangi Sarah Regiane do Nascimento Rocha Layne Even Borges de Souza Lucyane Mendes Silva Yudi Tatiana Pinilla Norbert Becker Wuelton Marcelo Monteiro Marcus Vinicius Guimarães de Lacerda Tainá Silva Secundino Raquel Soares Maia Godoy Nilton Barnabé Rodrigues Nágila Francinete Costa Secundino Gisely Cardoso de Melo Paulo Filemon Paolucci Pimenta |
| author_sort | Erika Gómez Martinez |
| collection | DOAJ |
| description | Objectives: The World Health Organization recommends three drug anti-malarial combinations: cloroquine+primaquine, artesiminin+primaquine, and cloroquine+tafenoquine. These combinations aim to eradicate Plasmodium by disrupting its life cycle within the human body. We evaluated the effect of these medications on the vectorial competence of two main vectors in the New World. Methods: We recruited patients diagnosed with malaria vivax from a primary care in Manaus, Amazonas. To determine how different treatments affected vectors, we collected blood samples prior to treatment at the hospital and at six intervals over the next 68 hours at the patient's homes. These samples were used to infect Anopheles darlingi and Anopheles aquasalis. To assess the potential for Plasmodium transmission by bite to a new human host, we analyzed the infection intensity, infection rate, and presence of parasites in the salivary gland of the mosquitoes. Results: The results show the infection of the mosquitoes fed with the patient's blood during the first days of treatment with all three drug combinations. However, the cloroquine+tafenoquine combination was the least effective while artesiminin+primaquine was the most effective. Conclusions: In the first few days of treatment, two main vectors continue to spread malaria vivax from patients, potentially contributing to the ongoing transmission in malaria-endemic regions. |
| format | Article |
| id | doaj-art-20764f38cf8246199656a74c49d2fef6 |
| institution | OA Journals |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-01-01 |
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| series | International Journal of Infectious Diseases |
| spelling | doaj-art-20764f38cf8246199656a74c49d2fef62025-08-20T01:57:51ZengElsevierInternational Journal of Infectious Diseases1201-97122025-01-0115010729710.1016/j.ijid.2024.107297Relative efficacy of anti-Plasmodium vivax malaria combination drugs in preventing transmission to two major Anopheles mosquitoes in the first few days of treatmentErika Gómez Martinez0Rodrigo Maciel Alencar1Rosa Amélia Gonçalves Santana2Laila Rowena Albuquerque Barbosa3Anne Cristine Gomes de Almeida4Victor Irungu Mwangi5Sarah Regiane do Nascimento Rocha6Layne Even Borges de Souza7Lucyane Mendes Silva8Yudi Tatiana Pinilla9Norbert Becker10Wuelton Marcelo Monteiro11Marcus Vinicius Guimarães de Lacerda12Tainá Silva Secundino13Raquel Soares Maia Godoy14Nilton Barnabé Rodrigues15Nágila Francinete Costa Secundino16Gisely Cardoso de Melo17Paulo Filemon Paolucci Pimenta18Programa de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, BrazilInstitute of Tropical Medicine, University Hospital Tübingen, Tübingen, GermanyCenter for Organismal Studies (COS), University of Heidelberg, Heidelberg, GermanyPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, Brazil; Instituto de Pesquisas Leônidas e Maria Deane, Fundação Oswaldo Cruz, Manaus, BrazilLaboratório de Entomologia Médica, Instituto de Pesquisas René Rachou, Fundação Oswaldo Cruz Minas, Belo Horizonte, Minas Gerais, BrazilLaboratório de Entomologia Médica, Instituto de Pesquisas René Rachou, Fundação Oswaldo Cruz Minas, Belo Horizonte, Minas Gerais, BrazilLaboratório de Entomologia Médica, Instituto de Pesquisas René Rachou, Fundação Oswaldo Cruz Minas, Belo Horizonte, Minas Gerais, BrazilPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, Brazil; Laboratório de Entomologia Médica, Instituto de Pesquisas René Rachou, Fundação Oswaldo Cruz Minas, Belo Horizonte, Minas Gerais, BrazilPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Fundação de Medicina Tropical Heitor Vieira Dourado, Universidade do Estado do Amazonas, Manaus, Brazil; Laboratório de Entomologia Médica, Instituto de Pesquisas René Rachou, Fundação Oswaldo Cruz Minas, Belo Horizonte, Minas Gerais, Brazil; Corresponding author: Tel.: (55) 31 982020634.Objectives: The World Health Organization recommends three drug anti-malarial combinations: cloroquine+primaquine, artesiminin+primaquine, and cloroquine+tafenoquine. These combinations aim to eradicate Plasmodium by disrupting its life cycle within the human body. We evaluated the effect of these medications on the vectorial competence of two main vectors in the New World. Methods: We recruited patients diagnosed with malaria vivax from a primary care in Manaus, Amazonas. To determine how different treatments affected vectors, we collected blood samples prior to treatment at the hospital and at six intervals over the next 68 hours at the patient's homes. These samples were used to infect Anopheles darlingi and Anopheles aquasalis. To assess the potential for Plasmodium transmission by bite to a new human host, we analyzed the infection intensity, infection rate, and presence of parasites in the salivary gland of the mosquitoes. Results: The results show the infection of the mosquitoes fed with the patient's blood during the first days of treatment with all three drug combinations. However, the cloroquine+tafenoquine combination was the least effective while artesiminin+primaquine was the most effective. Conclusions: In the first few days of treatment, two main vectors continue to spread malaria vivax from patients, potentially contributing to the ongoing transmission in malaria-endemic regions.http://www.sciencedirect.com/science/article/pii/S1201971224003734AnophelesPlasmodium vivaxAntimalarial drugsVector competence |
| spellingShingle | Erika Gómez Martinez Rodrigo Maciel Alencar Rosa Amélia Gonçalves Santana Laila Rowena Albuquerque Barbosa Anne Cristine Gomes de Almeida Victor Irungu Mwangi Sarah Regiane do Nascimento Rocha Layne Even Borges de Souza Lucyane Mendes Silva Yudi Tatiana Pinilla Norbert Becker Wuelton Marcelo Monteiro Marcus Vinicius Guimarães de Lacerda Tainá Silva Secundino Raquel Soares Maia Godoy Nilton Barnabé Rodrigues Nágila Francinete Costa Secundino Gisely Cardoso de Melo Paulo Filemon Paolucci Pimenta Relative efficacy of anti-Plasmodium vivax malaria combination drugs in preventing transmission to two major Anopheles mosquitoes in the first few days of treatment International Journal of Infectious Diseases Anopheles Plasmodium vivax Antimalarial drugs Vector competence |
| title | Relative efficacy of anti-Plasmodium vivax malaria combination drugs in preventing transmission to two major Anopheles mosquitoes in the first few days of treatment |
| title_full | Relative efficacy of anti-Plasmodium vivax malaria combination drugs in preventing transmission to two major Anopheles mosquitoes in the first few days of treatment |
| title_fullStr | Relative efficacy of anti-Plasmodium vivax malaria combination drugs in preventing transmission to two major Anopheles mosquitoes in the first few days of treatment |
| title_full_unstemmed | Relative efficacy of anti-Plasmodium vivax malaria combination drugs in preventing transmission to two major Anopheles mosquitoes in the first few days of treatment |
| title_short | Relative efficacy of anti-Plasmodium vivax malaria combination drugs in preventing transmission to two major Anopheles mosquitoes in the first few days of treatment |
| title_sort | relative efficacy of anti plasmodium vivax malaria combination drugs in preventing transmission to two major anopheles mosquitoes in the first few days of treatment |
| topic | Anopheles Plasmodium vivax Antimalarial drugs Vector competence |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224003734 |
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