Clinical outcomes and bone marker changes in postmenopausal women with dental implants: a one-year prospective study
Abstract Objectives The feasibility of dental implants in patients with osteoporosis remains controversial, with limited prospective studies on quantitative changes in bone mineral density (BMD) and bone turnover markers (BTMs). This study assessed implant survival and clinical outcomes while evalua...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-05-01
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| Series: | International Journal of Implant Dentistry |
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| Online Access: | https://doi.org/10.1186/s40729-025-00628-4 |
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| author | Jung Min Cho Namki Hong Yumie Rhee Wonse Park Kyung Chul Oh Yanggyung Seo Hwangyu Lee Hyeon-Gyu Jo Yunji Shin Jun-Young Kim |
| author_facet | Jung Min Cho Namki Hong Yumie Rhee Wonse Park Kyung Chul Oh Yanggyung Seo Hwangyu Lee Hyeon-Gyu Jo Yunji Shin Jun-Young Kim |
| author_sort | Jung Min Cho |
| collection | DOAJ |
| description | Abstract Objectives The feasibility of dental implants in patients with osteoporosis remains controversial, with limited prospective studies on quantitative changes in bone mineral density (BMD) and bone turnover markers (BTMs). This study assessed implant survival and clinical outcomes while evaluating systemic changes during 1 year of implant treatment. Materials and methods Postmenopausal women requiring dental implants were enrolled at the Yonsei University Dental Hospital. BMD and BTMs were evaluated in collaboration with the endocrinology department. Participants were divided into two groups: Group A (T-score ≥ -2) and Group B (T-score < -2). All implants used in the study were surface-treated with hydroxyethyl piperazine ethane sulfonic acid (HEPES), and clinical, radiographic, and systemic parameters were monitored for over 1 year. Results Between April 2022 and May 2024, 45 implants were placed in 36 patients (mean age: 68 years). Group A included 17 patients with 21 implants (mean age: 66 years), and Group B included 19 patients with 24 implants (mean age: 70 years). The cumulative survival rate was 100%. Resonance frequency analysis at 12 months revealed a mean implant stability tester value of 71.4 ± 5.52, indicating excellent osseointegration. Peri-implant bone loss averaged 0.54 ± 0.35 mm. No implant failures occurred, with stable plaque scores, probing depths, and bleeding upon probing. BMD and BTMs changes were minimal. Conclusions Both groups achieved high implant survival and stable clinical outcomes. Systemic evaluations confirmed only minor changes in BMD and BTMs over 1 year. Larger multicenter studies are required to confirm the systemic safety of dental implants in patients with osteoporosis. Clinical relevance Dental implants show excellent survival and stability in postmenopausal women with osteoporosis, with minimal impact on bone density and turnover—supporting their safe use in this population. Clinical trial registration This study was prospectively registered at the Clinical Research Information Service of the National Research Institute of Health, Republic of Korea (KCT0007100). The registration details can be accessed at https://cris.nih.go.kr . |
| format | Article |
| id | doaj-art-2076472d2d02466ca6ebe42ee96212c3 |
| institution | DOAJ |
| issn | 2198-4034 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | International Journal of Implant Dentistry |
| spelling | doaj-art-2076472d2d02466ca6ebe42ee96212c32025-08-20T03:08:42ZengSpringerOpenInternational Journal of Implant Dentistry2198-40342025-05-0111111210.1186/s40729-025-00628-4Clinical outcomes and bone marker changes in postmenopausal women with dental implants: a one-year prospective studyJung Min Cho0Namki Hong1Yumie Rhee2Wonse Park3Kyung Chul Oh4Yanggyung Seo5Hwangyu Lee6Hyeon-Gyu Jo7Yunji Shin8Jun-Young Kim9Department of Oral and Maxillofacial Surgery and Oral Science Research Center, Yonsei University College of DentistryDepartment of Internal Medicine, Endocrine Research Institute, Yonsei University College of MedicineDepartment of Internal Medicine, Endocrine Research Institute, Yonsei University College of MedicineDepartment of Advanced General Dentistry, Yonsei University College of DentistryDepartment of Prosthodontics, Yonsei University College of DentistryDepartment of Oral Science Research Center, Yonsei University College of DentistryDepartment of Oral and Maxillofacial Surgery and Oral Science Research Center, Yonsei University College of DentistryDepartment of Oral and Maxillofacial Surgery and Oral Science Research Center, Yonsei University College of DentistryDepartment of Oral Science Research Center, Yonsei University College of DentistryDepartment of Oral and Maxillofacial Surgery and Oral Science Research Center, Yonsei University College of DentistryAbstract Objectives The feasibility of dental implants in patients with osteoporosis remains controversial, with limited prospective studies on quantitative changes in bone mineral density (BMD) and bone turnover markers (BTMs). This study assessed implant survival and clinical outcomes while evaluating systemic changes during 1 year of implant treatment. Materials and methods Postmenopausal women requiring dental implants were enrolled at the Yonsei University Dental Hospital. BMD and BTMs were evaluated in collaboration with the endocrinology department. Participants were divided into two groups: Group A (T-score ≥ -2) and Group B (T-score < -2). All implants used in the study were surface-treated with hydroxyethyl piperazine ethane sulfonic acid (HEPES), and clinical, radiographic, and systemic parameters were monitored for over 1 year. Results Between April 2022 and May 2024, 45 implants were placed in 36 patients (mean age: 68 years). Group A included 17 patients with 21 implants (mean age: 66 years), and Group B included 19 patients with 24 implants (mean age: 70 years). The cumulative survival rate was 100%. Resonance frequency analysis at 12 months revealed a mean implant stability tester value of 71.4 ± 5.52, indicating excellent osseointegration. Peri-implant bone loss averaged 0.54 ± 0.35 mm. No implant failures occurred, with stable plaque scores, probing depths, and bleeding upon probing. BMD and BTMs changes were minimal. Conclusions Both groups achieved high implant survival and stable clinical outcomes. Systemic evaluations confirmed only minor changes in BMD and BTMs over 1 year. Larger multicenter studies are required to confirm the systemic safety of dental implants in patients with osteoporosis. Clinical relevance Dental implants show excellent survival and stability in postmenopausal women with osteoporosis, with minimal impact on bone density and turnover—supporting their safe use in this population. Clinical trial registration This study was prospectively registered at the Clinical Research Information Service of the National Research Institute of Health, Republic of Korea (KCT0007100). The registration details can be accessed at https://cris.nih.go.kr .https://doi.org/10.1186/s40729-025-00628-4OsteoporosisOsteopeniaDental implantsSurvival rateBone mineral densityBone turnover marker |
| spellingShingle | Jung Min Cho Namki Hong Yumie Rhee Wonse Park Kyung Chul Oh Yanggyung Seo Hwangyu Lee Hyeon-Gyu Jo Yunji Shin Jun-Young Kim Clinical outcomes and bone marker changes in postmenopausal women with dental implants: a one-year prospective study International Journal of Implant Dentistry Osteoporosis Osteopenia Dental implants Survival rate Bone mineral density Bone turnover marker |
| title | Clinical outcomes and bone marker changes in postmenopausal women with dental implants: a one-year prospective study |
| title_full | Clinical outcomes and bone marker changes in postmenopausal women with dental implants: a one-year prospective study |
| title_fullStr | Clinical outcomes and bone marker changes in postmenopausal women with dental implants: a one-year prospective study |
| title_full_unstemmed | Clinical outcomes and bone marker changes in postmenopausal women with dental implants: a one-year prospective study |
| title_short | Clinical outcomes and bone marker changes in postmenopausal women with dental implants: a one-year prospective study |
| title_sort | clinical outcomes and bone marker changes in postmenopausal women with dental implants a one year prospective study |
| topic | Osteoporosis Osteopenia Dental implants Survival rate Bone mineral density Bone turnover marker |
| url | https://doi.org/10.1186/s40729-025-00628-4 |
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