FYN regulates aqueous humor outflow and IOP through the phosphorylation of VE-CADHERIN

FYN regulates aqueous humor outflow and IOP through the phosphorylation of VE-CADHERIN

Abstract Schlemm’s canal endothelial cells (SECs) serve as the final barrier to aqueous humor (AQH) drainage from the eye. SECs adjust permeability to AQH outflow to modulate intraocular pressure (IOP). The broad identification of IOP-related genes implicates SECs in glaucoma. However, the molecular...

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Bibliographic Details
Main Authors: Krishnakumar Kizhatil, Graham M. Clark, Daniel K. Sunderland, Aakriti Bhandari, Logan J. Horbal, Revathi Balasubramanian, Simon W. M. John
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55232-8
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