Gut microbiota, physical activity and/or metabolic markers in healthy individuals - towards new biomarkers of health
BackgroundThe global prevalence of the metabolic disease Type 2 Diabetes (T2D) is increasing. Risk factors contributing to the development of T2D include overweight and obesity, lack of physical activity (PA), and an unhealthy diet. In addition, the gut microbiota has been shown to affect metabolic...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1438876/full |
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| author | Mari C. W. Myhrstad Emilia Ruud Line Gaundal Terje Gjøvaag Ida Rud Kjetil Retterstøl Stine M. Ulven Kirsten B. Holven Kirsten B. Holven Karsten Koehler Vibeke H. Telle-Hansen |
| author_facet | Mari C. W. Myhrstad Emilia Ruud Line Gaundal Terje Gjøvaag Ida Rud Kjetil Retterstøl Stine M. Ulven Kirsten B. Holven Kirsten B. Holven Karsten Koehler Vibeke H. Telle-Hansen |
| author_sort | Mari C. W. Myhrstad |
| collection | DOAJ |
| description | BackgroundThe global prevalence of the metabolic disease Type 2 Diabetes (T2D) is increasing. Risk factors contributing to the development of T2D include overweight and obesity, lack of physical activity (PA), and an unhealthy diet. In addition, the gut microbiota has been shown to affect metabolic regulation. Since T2D is preventable, efforts should be put into the discovery of new biomarkers for early detection of individuals at risk of developing the disease.ObjectiveThe objective of the cross-sectional study was to explore the relationship between gut microbiota and physical activity (PA) and/or metabolic markers such as selected amino acids (AA), markers of glycaemic regulation and lipid metabolism and anthropometric measures.DesignHealthy adults (18 and 65 years) with BMI between 18.5 and 27.5 kg/m2 originally recruited to a randomised controlled trial (RCT) (n = 17: six males, eleven females), were included in this exploratory cross-sectional study. Physical activity data was calculated based on a 3-days registration, and blood metabolome, gut microbiota analyses and anthropometric measures from one visit of the intervention were used in this cross-sectional study.ResultsOf the 47 gut bacteria analysed, there were a total of 87 significant correlations with AA, PA, body composition and/or metabolic markers. Several of the gut bacteria correlated with both PA, metabolic or anthropometric markers.ConclusionIn this study, we demonstrate associations between gut bacteria and PA and/or metabolic markers including AA in healthy individuals. The results may guide future studies aiming at identifying new and early biomarkers of metabolic health and diseases. |
| format | Article |
| id | doaj-art-2074208f96b9407cbd26d2bc56ddf069 |
| institution | DOAJ |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-2074208f96b9407cbd26d2bc56ddf0692025-08-20T02:49:05ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-11-011110.3389/fnut.2024.14388761438876Gut microbiota, physical activity and/or metabolic markers in healthy individuals - towards new biomarkers of healthMari C. W. Myhrstad0Emilia Ruud1Line Gaundal2Terje Gjøvaag3Ida Rud4Kjetil Retterstøl5Stine M. Ulven6Kirsten B. Holven7Kirsten B. Holven8Karsten Koehler9Vibeke H. Telle-Hansen10Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, NorwayDepartment of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, NorwayDepartment of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, NorwayDepartment of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, NorwayNofima-Norwegian Institute of Food, Fisheries and Aquaculture Research, Ås, NorwayDepartment of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, NorwayDepartment of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, NorwayDepartment of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, NorwayNorwegian National Advisory Unit on Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Aker, Oslo, NorwayDepartment of Health and Sport Sciences, School of Medicine and Health, Technical University of Munich, Munich, GermanyDepartment of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, NorwayBackgroundThe global prevalence of the metabolic disease Type 2 Diabetes (T2D) is increasing. Risk factors contributing to the development of T2D include overweight and obesity, lack of physical activity (PA), and an unhealthy diet. In addition, the gut microbiota has been shown to affect metabolic regulation. Since T2D is preventable, efforts should be put into the discovery of new biomarkers for early detection of individuals at risk of developing the disease.ObjectiveThe objective of the cross-sectional study was to explore the relationship between gut microbiota and physical activity (PA) and/or metabolic markers such as selected amino acids (AA), markers of glycaemic regulation and lipid metabolism and anthropometric measures.DesignHealthy adults (18 and 65 years) with BMI between 18.5 and 27.5 kg/m2 originally recruited to a randomised controlled trial (RCT) (n = 17: six males, eleven females), were included in this exploratory cross-sectional study. Physical activity data was calculated based on a 3-days registration, and blood metabolome, gut microbiota analyses and anthropometric measures from one visit of the intervention were used in this cross-sectional study.ResultsOf the 47 gut bacteria analysed, there were a total of 87 significant correlations with AA, PA, body composition and/or metabolic markers. Several of the gut bacteria correlated with both PA, metabolic or anthropometric markers.ConclusionIn this study, we demonstrate associations between gut bacteria and PA and/or metabolic markers including AA in healthy individuals. The results may guide future studies aiming at identifying new and early biomarkers of metabolic health and diseases.https://www.frontiersin.org/articles/10.3389/fnut.2024.1438876/fullphysical activitygut microbiotametabolic markersaromatic amino acidshealthy individuals |
| spellingShingle | Mari C. W. Myhrstad Emilia Ruud Line Gaundal Terje Gjøvaag Ida Rud Kjetil Retterstøl Stine M. Ulven Kirsten B. Holven Kirsten B. Holven Karsten Koehler Vibeke H. Telle-Hansen Gut microbiota, physical activity and/or metabolic markers in healthy individuals - towards new biomarkers of health Frontiers in Nutrition physical activity gut microbiota metabolic markers aromatic amino acids healthy individuals |
| title | Gut microbiota, physical activity and/or metabolic markers in healthy individuals - towards new biomarkers of health |
| title_full | Gut microbiota, physical activity and/or metabolic markers in healthy individuals - towards new biomarkers of health |
| title_fullStr | Gut microbiota, physical activity and/or metabolic markers in healthy individuals - towards new biomarkers of health |
| title_full_unstemmed | Gut microbiota, physical activity and/or metabolic markers in healthy individuals - towards new biomarkers of health |
| title_short | Gut microbiota, physical activity and/or metabolic markers in healthy individuals - towards new biomarkers of health |
| title_sort | gut microbiota physical activity and or metabolic markers in healthy individuals towards new biomarkers of health |
| topic | physical activity gut microbiota metabolic markers aromatic amino acids healthy individuals |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1438876/full |
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