Penile Livedoid Vasculopathy: First Reported Case
Livedoid vasculopathy is a thromboocclusive cutaneous vasculopathy manifested by livedoid changes, atrophie blanche, and ulceration. The pathogenesis is speculated to involve increasing coagulation or impaired thrombolysis leading to the occlusion of dermal blood vessels with fibrin thrombi. Livedoi...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Case Reports in Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2023/6920383 |
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| author | Ahmad Hallak William Bennett Mohammed Adib Tanbir Supriya R. Donthamsetty Bethaney Vincent |
| author_facet | Ahmad Hallak William Bennett Mohammed Adib Tanbir Supriya R. Donthamsetty Bethaney Vincent |
| author_sort | Ahmad Hallak |
| collection | DOAJ |
| description | Livedoid vasculopathy is a thromboocclusive cutaneous vasculopathy manifested by livedoid changes, atrophie blanche, and ulceration. The pathogenesis is speculated to involve increasing coagulation or impaired thrombolysis leading to the occlusion of dermal blood vessels with fibrin thrombi. Livedoid vasculopathy is known to primarily affect the lower extremities. We report the first case of livedoid vasculopathy affecting the penis. A 60-year-old male was evaluated for a split urine stream with associated irritation and peeling of the skin of the glans penis. His penile ulcer continued to enlarge despite steroids and antibiotics. Due to diagnostic uncertainty, a biopsy was performed which revealed hyaline thrombi within the lumens of small vessels within the upper to mid dermis, fibrinoid material in the walls of these blood vessels and within the perivascular stroma with overlying and adjacent epidermal spongiosis, and mild perivascular lymphocytic infiltrate with a few scattered neutrophils most consistent with livedoid vasculitis. He was started on aspirin and pentoxifylline with limited improvement and was later started on apixaban with near-complete resolution in 6 months. Penile livedoid vasculopathy has not been previously reported in the English literature. Early diagnosis and treatment are imperative to limit morbidity. |
| format | Article |
| id | doaj-art-20712fdf84aa4c1c953ad464c24fae3b |
| institution | Kabale University |
| issn | 2090-6994 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Vascular Medicine |
| spelling | doaj-art-20712fdf84aa4c1c953ad464c24fae3b2025-02-03T06:48:32ZengWileyCase Reports in Vascular Medicine2090-69942023-01-01202310.1155/2023/6920383Penile Livedoid Vasculopathy: First Reported CaseAhmad Hallak0William Bennett1Mohammed Adib Tanbir2Supriya R. Donthamsetty3Bethaney Vincent4Ochsner Medical CenterOchsner Medical CenterTexas Tech University Health Sciences CenterOchsner Medical CenterOchsner Medical CenterLivedoid vasculopathy is a thromboocclusive cutaneous vasculopathy manifested by livedoid changes, atrophie blanche, and ulceration. The pathogenesis is speculated to involve increasing coagulation or impaired thrombolysis leading to the occlusion of dermal blood vessels with fibrin thrombi. Livedoid vasculopathy is known to primarily affect the lower extremities. We report the first case of livedoid vasculopathy affecting the penis. A 60-year-old male was evaluated for a split urine stream with associated irritation and peeling of the skin of the glans penis. His penile ulcer continued to enlarge despite steroids and antibiotics. Due to diagnostic uncertainty, a biopsy was performed which revealed hyaline thrombi within the lumens of small vessels within the upper to mid dermis, fibrinoid material in the walls of these blood vessels and within the perivascular stroma with overlying and adjacent epidermal spongiosis, and mild perivascular lymphocytic infiltrate with a few scattered neutrophils most consistent with livedoid vasculitis. He was started on aspirin and pentoxifylline with limited improvement and was later started on apixaban with near-complete resolution in 6 months. Penile livedoid vasculopathy has not been previously reported in the English literature. Early diagnosis and treatment are imperative to limit morbidity.http://dx.doi.org/10.1155/2023/6920383 |
| spellingShingle | Ahmad Hallak William Bennett Mohammed Adib Tanbir Supriya R. Donthamsetty Bethaney Vincent Penile Livedoid Vasculopathy: First Reported Case Case Reports in Vascular Medicine |
| title | Penile Livedoid Vasculopathy: First Reported Case |
| title_full | Penile Livedoid Vasculopathy: First Reported Case |
| title_fullStr | Penile Livedoid Vasculopathy: First Reported Case |
| title_full_unstemmed | Penile Livedoid Vasculopathy: First Reported Case |
| title_short | Penile Livedoid Vasculopathy: First Reported Case |
| title_sort | penile livedoid vasculopathy first reported case |
| url | http://dx.doi.org/10.1155/2023/6920383 |
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