A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS
Objective: Immunoglobulin A vasculitis (IgAV) is the most prevalent systemic vasculitis in childhood. This intricate immune-mediated vasculitis affects the small blood vessels in several organ systems. Complements 3 and 4 (C3 and C4) are constituents of the complement system; serum C3/ C4 measuremen...
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Istanbul University Press
2025-03-01
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/C575857017CD4903B9EE95B2A27F218D |
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| author | Şeyda Doğantan Sema Nur Taşkın |
| author_facet | Şeyda Doğantan Sema Nur Taşkın |
| author_sort | Şeyda Doğantan |
| collection | DOAJ |
| description | Objective: Immunoglobulin A vasculitis (IgAV) is the most prevalent systemic vasculitis in childhood. This intricate immune-mediated vasculitis affects the small blood vessels in several organ systems. Complements 3 and 4 (C3 and C4) are constituents of the complement system; serum C3/ C4 measurements play aMaterial and Methods: A total of 124 children—60 IgAV patients and 64 healthy controls—were assessed in this study. The C3 and C4 levels were quantified using a turbidimetric immunoassays method with manufacturer details. The extractable nuclear antigen antibody (ENA) panels were evaluated using the ELISA method. The results were evaluated statistically. Results: The white blood cell count, neutrophil count, and neutrophil/ lymphocyte ratio were higher in the patient group compared to the control group (p=0.015, p=0.013 and p=0.039, respectively). CRP, ESR, and random urine protein/creatinine ratio (RUPCR) increased in patients than controls (p<0.001, p=0.002 and p<0.001 respectively). There was no difference in the lupus anticoagulant activity and low C3/C4 levels between the groups (p˃0.05). Conclusion: IgAV, an IgA-mediated systemic small vessel vasculitis, affects many organs. As a result, it is crucial to evaluate the laboratory results in the follow-up of the patient and the possible complications. |
| format | Article |
| id | doaj-art-206e81ba766e40aabd93047432583306 |
| institution | OA Journals |
| issn | 2651-4060 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | Sabiad |
| spelling | doaj-art-206e81ba766e40aabd930474325833062025-08-20T02:27:31ZengIstanbul University PressSabiad2651-40602025-03-0181475210.26650/JARHS2025-1582236123456A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITISŞeyda Doğantan0https://orcid.org/0000-0002-9082-6804Sema Nur Taşkın1https://orcid.org/0000-0003-3400-1514İstanbul Başakşehir Çam ve Sakura Şehir Hastanesi, İstanbul, TürkiyeEskişehir City Hospital, Eskişehir, TürkiyeObjective: Immunoglobulin A vasculitis (IgAV) is the most prevalent systemic vasculitis in childhood. This intricate immune-mediated vasculitis affects the small blood vessels in several organ systems. Complements 3 and 4 (C3 and C4) are constituents of the complement system; serum C3/ C4 measurements play aMaterial and Methods: A total of 124 children—60 IgAV patients and 64 healthy controls—were assessed in this study. The C3 and C4 levels were quantified using a turbidimetric immunoassays method with manufacturer details. The extractable nuclear antigen antibody (ENA) panels were evaluated using the ELISA method. The results were evaluated statistically. Results: The white blood cell count, neutrophil count, and neutrophil/ lymphocyte ratio were higher in the patient group compared to the control group (p=0.015, p=0.013 and p=0.039, respectively). CRP, ESR, and random urine protein/creatinine ratio (RUPCR) increased in patients than controls (p<0.001, p=0.002 and p<0.001 respectively). There was no difference in the lupus anticoagulant activity and low C3/C4 levels between the groups (p˃0.05). Conclusion: IgAV, an IgA-mediated systemic small vessel vasculitis, affects many organs. As a result, it is crucial to evaluate the laboratory results in the follow-up of the patient and the possible complications.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/C575857017CD4903B9EE95B2A27F218Dimmunoglobulin a vasculitisc3c4immunoassay |
| spellingShingle | Şeyda Doğantan Sema Nur Taşkın A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS Sabiad immunoglobulin a vasculitis c3 c4 immunoassay |
| title | A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS |
| title_full | A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS |
| title_fullStr | A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS |
| title_full_unstemmed | A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS |
| title_short | A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS |
| title_sort | single centre experience of low c3 c4 levels and other laboratory aspects in turkish children with immunoglobulin a vasculitis |
| topic | immunoglobulin a vasculitis c3 c4 immunoassay |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/C575857017CD4903B9EE95B2A27F218D |
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