Aggressive forms of pituitary adenomas (literature review and clinical observation)
Introduction. Pituitary adenomas comprise 10–15 % of all intracranial tumors. Despite being benign tumors, 25–55 % of them exhibit invasive growth spreading into surrounding structures (sphenoid sinus, cavernous sinus, etc.). In literature, there isn’t a generally accepted definition of aggressive p...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2018-01-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/313 |
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| author | P. L. Kalinin Yu. Yu. Trunin D. V. Fomichev I. V. Chernov M. V. Ryzhova |
| author_facet | P. L. Kalinin Yu. Yu. Trunin D. V. Fomichev I. V. Chernov M. V. Ryzhova |
| author_sort | P. L. Kalinin |
| collection | DOAJ |
| description | Introduction. Pituitary adenomas comprise 10–15 % of all intracranial tumors. Despite being benign tumors, 25–55 % of them exhibit invasive growth spreading into surrounding structures (sphenoid sinus, cavernous sinus, etc.). In literature, there isn’t a generally accepted definition of aggressive pituitary adenomas. As a result, there aren’t any studies reporting on the therapy of choice for this disease, except for several reports on using temozolomide as a “salvage” therapy in patients who didn’t respond to standard treatment methods.We present a clinical observation of a patient with “refractory” pituitary adenoma who successfully underwent 4 surgical interventions and 2 courses of high-dose stereotactic radiotherapy.Results. Application of stereotactic radiotherapy at high (59.4 Gy) dose, which is usually used for treatment of patients with malignant tumors, allowed to achieve long recurrence-free period of 5.5 years (65 months). Observation has shown that repeated courses of stereotactic irradiation can be sufficiently effective and safe in patients with large and gigantic tumors including “refractory” pituitary adenoma.Conclusion. Further studies are necessary for specification of parameters of “refractory” adenomas and their detection at the early stages of diagnosis. Confirmed diagnosis requires more aggressive surgical, radiological, and drug treatment. |
| format | Article |
| id | doaj-art-206d0ef4b09946cbb941256b2a443ff5 |
| institution | DOAJ |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2018-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-206d0ef4b09946cbb941256b2a443ff52025-08-20T03:01:12ZrusABV-pressОпухоли головы и шеи2222-14682411-46342018-01-0174748010.17650/2222-1468-2017-7-4-846283Aggressive forms of pituitary adenomas (literature review and clinical observation)P. L. Kalinin0Yu. Yu. Trunin1D. V. Fomichev2I. V. Chernov3M. V. Ryzhova4N. N. Burdenko National Medical Research Center for Neurosurgery, Ministry of Health of Russia;N. N. Burdenko National Medical Research Center for Neurosurgery, Ministry of Health of Russia;N. N. Burdenko National Medical Research Center for Neurosurgery, Ministry of Health of Russia;N. N. Burdenko National Medical Research Center for Neurosurgery, Ministry of Health of Russia;N. N. Burdenko National Medical Research Center for Neurosurgery, Ministry of Health of Russia;Introduction. Pituitary adenomas comprise 10–15 % of all intracranial tumors. Despite being benign tumors, 25–55 % of them exhibit invasive growth spreading into surrounding structures (sphenoid sinus, cavernous sinus, etc.). In literature, there isn’t a generally accepted definition of aggressive pituitary adenomas. As a result, there aren’t any studies reporting on the therapy of choice for this disease, except for several reports on using temozolomide as a “salvage” therapy in patients who didn’t respond to standard treatment methods.We present a clinical observation of a patient with “refractory” pituitary adenoma who successfully underwent 4 surgical interventions and 2 courses of high-dose stereotactic radiotherapy.Results. Application of stereotactic radiotherapy at high (59.4 Gy) dose, which is usually used for treatment of patients with malignant tumors, allowed to achieve long recurrence-free period of 5.5 years (65 months). Observation has shown that repeated courses of stereotactic irradiation can be sufficiently effective and safe in patients with large and gigantic tumors including “refractory” pituitary adenoma.Conclusion. Further studies are necessary for specification of parameters of “refractory” adenomas and their detection at the early stages of diagnosis. Confirmed diagnosis requires more aggressive surgical, radiological, and drug treatment.https://ogsh.abvpress.ru/jour/article/view/313aggressive pituitary adenomasradiotherapy of aggressive pituitary adenomas |
| spellingShingle | P. L. Kalinin Yu. Yu. Trunin D. V. Fomichev I. V. Chernov M. V. Ryzhova Aggressive forms of pituitary adenomas (literature review and clinical observation) Опухоли головы и шеи aggressive pituitary adenomas radiotherapy of aggressive pituitary adenomas |
| title | Aggressive forms of pituitary adenomas (literature review and clinical observation) |
| title_full | Aggressive forms of pituitary adenomas (literature review and clinical observation) |
| title_fullStr | Aggressive forms of pituitary adenomas (literature review and clinical observation) |
| title_full_unstemmed | Aggressive forms of pituitary adenomas (literature review and clinical observation) |
| title_short | Aggressive forms of pituitary adenomas (literature review and clinical observation) |
| title_sort | aggressive forms of pituitary adenomas literature review and clinical observation |
| topic | aggressive pituitary adenomas radiotherapy of aggressive pituitary adenomas |
| url | https://ogsh.abvpress.ru/jour/article/view/313 |
| work_keys_str_mv | AT plkalinin aggressiveformsofpituitaryadenomasliteraturereviewandclinicalobservation AT yuyutrunin aggressiveformsofpituitaryadenomasliteraturereviewandclinicalobservation AT dvfomichev aggressiveformsofpituitaryadenomasliteraturereviewandclinicalobservation AT ivchernov aggressiveformsofpituitaryadenomasliteraturereviewandclinicalobservation AT mvryzhova aggressiveformsofpituitaryadenomasliteraturereviewandclinicalobservation |