Association between rheumatoid arthritis and interstitial lung disease and impact of serologic status: a large-scale longitudinal study
Abstract Interstitial lung disease (ILD) leads to worse outcomes in subjects with rheumatoid arthritis (RA). Few large-scale longitudinal studies have provided comprehensive data on the incidence and risk of ILD in RA compared with non-RA populations. We compare the risk of incident ILD in subjects...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-88323-7 |
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| author | Bo-Guen Kim Hyun Lee Yeonghee Eun Kyungdo Han Jin-Hyung Jung Hayoung Choi Hyungjin Kim Dong Wook Shin |
| author_facet | Bo-Guen Kim Hyun Lee Yeonghee Eun Kyungdo Han Jin-Hyung Jung Hayoung Choi Hyungjin Kim Dong Wook Shin |
| author_sort | Bo-Guen Kim |
| collection | DOAJ |
| description | Abstract Interstitial lung disease (ILD) leads to worse outcomes in subjects with rheumatoid arthritis (RA). Few large-scale longitudinal studies have provided comprehensive data on the incidence and risk of ILD in RA compared with non-RA populations. We compare the risk of incident ILD in subjects with RA and matched controls, while also evaluating the impact of RA serologic status. Using the Korean National Health Insurance Service Data between 2010 and 2017, we identified 52,325 individuals with RA and 261,625 without RA. During a median follow-up period of 4.4 years, 3.7% of the RA cohort and 0.5% of the matched cohort developed ILD, with incidence rates of 8.30 and 1.01 per 1,000 person-years. Compared to controls, the risk of incident ILD was significantly higher in the RA cohort (adjusted hazard ratio [aHR] 7.84 [7.29–8.44]), and seropositive and seronegative RA exhibited aHRs of 9.00 (8.34–9.72) and 4.81 (4.25–5.44). Although the risk of ILD was higher in seropositive RA than seronegative RA, the risk of developing ILD was also higher in subjects with seronegative RA than in matched controls, suggesting that close monitoring for ILD should be performed in this population. |
| format | Article |
| id | doaj-art-206d0933c7524db6aa44a3d5b8116d4b |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-206d0933c7524db6aa44a3d5b8116d4b2025-08-20T02:43:15ZengNature PortfolioScientific Reports2045-23222025-02-0115111110.1038/s41598-025-88323-7Association between rheumatoid arthritis and interstitial lung disease and impact of serologic status: a large-scale longitudinal studyBo-Guen Kim0Hyun Lee1Yeonghee Eun2Kyungdo Han3Jin-Hyung Jung4Hayoung Choi5Hyungjin Kim6Dong Wook Shin7Division of Pulmonary Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of MedicineDivision of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of MedicineDivision of Rheumatology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of MedicineDepartment of Statistics and Actuarial Science, Soongsil UniversitySamsung Biomedical Research Institute, Sungkyunkwan University School of MedicineDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of MedicineDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Family Medicine & Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of MedicineAbstract Interstitial lung disease (ILD) leads to worse outcomes in subjects with rheumatoid arthritis (RA). Few large-scale longitudinal studies have provided comprehensive data on the incidence and risk of ILD in RA compared with non-RA populations. We compare the risk of incident ILD in subjects with RA and matched controls, while also evaluating the impact of RA serologic status. Using the Korean National Health Insurance Service Data between 2010 and 2017, we identified 52,325 individuals with RA and 261,625 without RA. During a median follow-up period of 4.4 years, 3.7% of the RA cohort and 0.5% of the matched cohort developed ILD, with incidence rates of 8.30 and 1.01 per 1,000 person-years. Compared to controls, the risk of incident ILD was significantly higher in the RA cohort (adjusted hazard ratio [aHR] 7.84 [7.29–8.44]), and seropositive and seronegative RA exhibited aHRs of 9.00 (8.34–9.72) and 4.81 (4.25–5.44). Although the risk of ILD was higher in seropositive RA than seronegative RA, the risk of developing ILD was also higher in subjects with seronegative RA than in matched controls, suggesting that close monitoring for ILD should be performed in this population.https://doi.org/10.1038/s41598-025-88323-7Rheumatoid arthritisInterstitial lung diseaseEpidemiologyRisk |
| spellingShingle | Bo-Guen Kim Hyun Lee Yeonghee Eun Kyungdo Han Jin-Hyung Jung Hayoung Choi Hyungjin Kim Dong Wook Shin Association between rheumatoid arthritis and interstitial lung disease and impact of serologic status: a large-scale longitudinal study Scientific Reports Rheumatoid arthritis Interstitial lung disease Epidemiology Risk |
| title | Association between rheumatoid arthritis and interstitial lung disease and impact of serologic status: a large-scale longitudinal study |
| title_full | Association between rheumatoid arthritis and interstitial lung disease and impact of serologic status: a large-scale longitudinal study |
| title_fullStr | Association between rheumatoid arthritis and interstitial lung disease and impact of serologic status: a large-scale longitudinal study |
| title_full_unstemmed | Association between rheumatoid arthritis and interstitial lung disease and impact of serologic status: a large-scale longitudinal study |
| title_short | Association between rheumatoid arthritis and interstitial lung disease and impact of serologic status: a large-scale longitudinal study |
| title_sort | association between rheumatoid arthritis and interstitial lung disease and impact of serologic status a large scale longitudinal study |
| topic | Rheumatoid arthritis Interstitial lung disease Epidemiology Risk |
| url | https://doi.org/10.1038/s41598-025-88323-7 |
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