Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana
Abstract (+)-cis-12-oxo-phytodienoic acid (cis-OPDA) is a biosynthetic precursor of the plant hormone (+)−7-iso-Jasmonoyl-L-isoleucine (JA-Ile). It was proposed as an endogenous chemical signal independent of the JA-Ile receptor COI1-JAZ in Arabidopsis thaliana. The bioactive form of cis-OPDA that i...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61072-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849234599132004352 |
|---|---|
| author | Minoru Ueda Rina Saito Yuho Nishizato Tsumugi Kitajima Nobuki Kato |
| author_facet | Minoru Ueda Rina Saito Yuho Nishizato Tsumugi Kitajima Nobuki Kato |
| author_sort | Minoru Ueda |
| collection | DOAJ |
| description | Abstract (+)-cis-12-oxo-phytodienoic acid (cis-OPDA) is a biosynthetic precursor of the plant hormone (+)−7-iso-Jasmonoyl-L-isoleucine (JA-Ile). It was proposed as an endogenous chemical signal independent of the JA-Ile receptor COI1-JAZ in Arabidopsis thaliana. The bioactive form of cis-OPDA that induces COI1-JAZ-independent gene expression remains unknown. Here we demonstrate that the downstream metabolites of cis-OPDA, especially tetranor-cis-OPDA (tn-cis-OPDA) and 7-iso-4,5-didehydro-JA (4,5-ddh-JA), upregulate the expression of the OPDA marker genes such as ZAT10 and ERF5. These downstream metabolites function independently of the JA-Ile-COI1-JAZ-MYCs canonical jasmonate signaling module, and their electrophilic α, β-unsaturated carbonyl functionalities are essential for their bioactivity. These results raise a possibility that the downstream metabolites of cis-OPDA would function as endogenous chemical signal in A. thaliana. |
| format | Article |
| id | doaj-art-206abb297034410b87c50b0dcd4df6e9 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-206abb297034410b87c50b0dcd4df6e92025-08-20T04:03:06ZengNature PortfolioNature Communications2041-17232025-07-0116111310.1038/s41467-025-61072-xDownstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thalianaMinoru Ueda0Rina Saito1Yuho Nishizato2Tsumugi Kitajima3Nobuki Kato4Department of Chemistry, Graduate School of Science, Tohoku UniversityDepartment of Molecular and Chemical Life Sciences, Graduate School of Life Sciences, Tohoku UniversityDepartment of Chemistry, Graduate School of Science, Tohoku UniversityDepartment of Molecular and Chemical Life Sciences, Graduate School of Life Sciences, Tohoku UniversityDepartment of Chemistry, Graduate School of Science, Tohoku UniversityAbstract (+)-cis-12-oxo-phytodienoic acid (cis-OPDA) is a biosynthetic precursor of the plant hormone (+)−7-iso-Jasmonoyl-L-isoleucine (JA-Ile). It was proposed as an endogenous chemical signal independent of the JA-Ile receptor COI1-JAZ in Arabidopsis thaliana. The bioactive form of cis-OPDA that induces COI1-JAZ-independent gene expression remains unknown. Here we demonstrate that the downstream metabolites of cis-OPDA, especially tetranor-cis-OPDA (tn-cis-OPDA) and 7-iso-4,5-didehydro-JA (4,5-ddh-JA), upregulate the expression of the OPDA marker genes such as ZAT10 and ERF5. These downstream metabolites function independently of the JA-Ile-COI1-JAZ-MYCs canonical jasmonate signaling module, and their electrophilic α, β-unsaturated carbonyl functionalities are essential for their bioactivity. These results raise a possibility that the downstream metabolites of cis-OPDA would function as endogenous chemical signal in A. thaliana.https://doi.org/10.1038/s41467-025-61072-x |
| spellingShingle | Minoru Ueda Rina Saito Yuho Nishizato Tsumugi Kitajima Nobuki Kato Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana Nature Communications |
| title | Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana |
| title_full | Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana |
| title_fullStr | Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana |
| title_full_unstemmed | Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana |
| title_short | Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana |
| title_sort | downstream metabolites of cis 12 oxo phytodienoic acid function as noncanonical bioactive jasmonates in arabidopsis thaliana |
| url | https://doi.org/10.1038/s41467-025-61072-x |
| work_keys_str_mv | AT minoruueda downstreammetabolitesofcis12oxophytodienoicacidfunctionasnoncanonicalbioactivejasmonatesinarabidopsisthaliana AT rinasaito downstreammetabolitesofcis12oxophytodienoicacidfunctionasnoncanonicalbioactivejasmonatesinarabidopsisthaliana AT yuhonishizato downstreammetabolitesofcis12oxophytodienoicacidfunctionasnoncanonicalbioactivejasmonatesinarabidopsisthaliana AT tsumugikitajima downstreammetabolitesofcis12oxophytodienoicacidfunctionasnoncanonicalbioactivejasmonatesinarabidopsisthaliana AT nobukikato downstreammetabolitesofcis12oxophytodienoicacidfunctionasnoncanonicalbioactivejasmonatesinarabidopsisthaliana |