Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome

Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome

Summary: Interstitial renal inflammation contributes to the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Recently, lactylation modification has emerged as a mechanism for mediating chronic organ damage. We investigate lactylated protein profiles and the role of protein...

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Bibliographic Details
Main Authors: Fang Yu, Yan Meng, Xiaoyue Wang, Jia Chen, Junling He, Xiangling Yi, Yani He, Kehong Chen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008551
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