Unlocking cancer vaccine potential: What are the key factors?
Cancer is a global health challenge, with changing demographics and lifestyle factors producing an increasing burden worldwide. Screening advancements are enabling earlier diagnoses, but current cancer immunotherapies only induce remission in a small proportion of patients and come at a high cost. C...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2331486 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850185501956374528 |
|---|---|
| author | Michael Grant Lian Ni Lee Senthil Chinnakannan Orion Tong Jonathan Kwok Nicole Cianci Luke Tillman Abhishek Saha Vinnycius Pereira Almeida Carol Leung |
| author_facet | Michael Grant Lian Ni Lee Senthil Chinnakannan Orion Tong Jonathan Kwok Nicole Cianci Luke Tillman Abhishek Saha Vinnycius Pereira Almeida Carol Leung |
| author_sort | Michael Grant |
| collection | DOAJ |
| description | Cancer is a global health challenge, with changing demographics and lifestyle factors producing an increasing burden worldwide. Screening advancements are enabling earlier diagnoses, but current cancer immunotherapies only induce remission in a small proportion of patients and come at a high cost. Cancer vaccines may offer a solution to these challenges, but they have been mired by poor results in past decades. Greater understanding of tumor biology, coupled with the success of vaccine technologies during the COVID-19 pandemic, has reinvigorated cancer vaccine development. With the first signs of efficacy being reported, cancer vaccines may be beginning to fulfill their potential. Solid tumors, however, present different hurdles than infectious diseases. Combining insights from previous cancer vaccine clinical development and contemporary knowledge of tumor immunology, we ask: who are the ‘right’ patients, what are the ‘right’ targets, and which are the ‘right’ modalities to maximize the chances of cancer vaccine success? |
| format | Article |
| id | doaj-art-2063d6422adc4b1d89ff15bd2bb2b2e8 |
| institution | OA Journals |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-2063d6422adc4b1d89ff15bd2bb2b2e82025-08-20T02:16:44ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2331486Unlocking cancer vaccine potential: What are the key factors?Michael Grant0Lian Ni Lee1Senthil Chinnakannan2Orion Tong3Jonathan Kwok4Nicole Cianci5Luke Tillman6Abhishek Saha7Vinnycius Pereira Almeida8Carol Leung9Infinitopes Ltd, Oxford, UKInfinitopes Ltd, Oxford, UKInfinitopes Ltd, Oxford, UKInfinitopes Ltd, Oxford, UKInfinitopes Ltd, Oxford, UKOxford Health NHS Foundation Trust, Oxford, UKInfinitopes Ltd, Oxford, UKInfinitopes Ltd, Oxford, UKUniversity of Oxford, Oxford, UKUniversity of Oxford, Oxford, UKCancer is a global health challenge, with changing demographics and lifestyle factors producing an increasing burden worldwide. Screening advancements are enabling earlier diagnoses, but current cancer immunotherapies only induce remission in a small proportion of patients and come at a high cost. Cancer vaccines may offer a solution to these challenges, but they have been mired by poor results in past decades. Greater understanding of tumor biology, coupled with the success of vaccine technologies during the COVID-19 pandemic, has reinvigorated cancer vaccine development. With the first signs of efficacy being reported, cancer vaccines may be beginning to fulfill their potential. Solid tumors, however, present different hurdles than infectious diseases. Combining insights from previous cancer vaccine clinical development and contemporary knowledge of tumor immunology, we ask: who are the ‘right’ patients, what are the ‘right’ targets, and which are the ‘right’ modalities to maximize the chances of cancer vaccine success?https://www.tandfonline.com/doi/10.1080/21645515.2024.2331486Cancer vaccinesolid tumorsimmunotherapycancer antigentumor biologyclinical development |
| spellingShingle | Michael Grant Lian Ni Lee Senthil Chinnakannan Orion Tong Jonathan Kwok Nicole Cianci Luke Tillman Abhishek Saha Vinnycius Pereira Almeida Carol Leung Unlocking cancer vaccine potential: What are the key factors? Human Vaccines & Immunotherapeutics Cancer vaccine solid tumors immunotherapy cancer antigen tumor biology clinical development |
| title | Unlocking cancer vaccine potential: What are the key factors? |
| title_full | Unlocking cancer vaccine potential: What are the key factors? |
| title_fullStr | Unlocking cancer vaccine potential: What are the key factors? |
| title_full_unstemmed | Unlocking cancer vaccine potential: What are the key factors? |
| title_short | Unlocking cancer vaccine potential: What are the key factors? |
| title_sort | unlocking cancer vaccine potential what are the key factors |
| topic | Cancer vaccine solid tumors immunotherapy cancer antigen tumor biology clinical development |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2331486 |
| work_keys_str_mv | AT michaelgrant unlockingcancervaccinepotentialwhatarethekeyfactors AT liannilee unlockingcancervaccinepotentialwhatarethekeyfactors AT senthilchinnakannan unlockingcancervaccinepotentialwhatarethekeyfactors AT oriontong unlockingcancervaccinepotentialwhatarethekeyfactors AT jonathankwok unlockingcancervaccinepotentialwhatarethekeyfactors AT nicolecianci unlockingcancervaccinepotentialwhatarethekeyfactors AT luketillman unlockingcancervaccinepotentialwhatarethekeyfactors AT abhisheksaha unlockingcancervaccinepotentialwhatarethekeyfactors AT vinnyciuspereiraalmeida unlockingcancervaccinepotentialwhatarethekeyfactors AT carolleung unlockingcancervaccinepotentialwhatarethekeyfactors |