Unveiling macrophage dynamics and efferocytosis-related targets in diabetic kidney disease: insights from single-cell and bulk RNA-sequencing

Unveiling macrophage dynamics and efferocytosis-related targets in diabetic kidney disease: insights from single-cell and bulk RNA-sequencing

BackgroundChronic inflammation and immune imbalance mediated by macrophages are considered pivotal in diabetic kidney disease (DKD). The study aims to clarify the macrophage heterogeneity and phenotype dynamics, and pinpoint critical targets within efferocytosis in DKD.MethodsUtilizing early human D...

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Bibliographic Details
Main Authors: Binshan Zhang, Yunqi Wu, Zhongli Wang, Suhua Gao, Hongyan Liu, Yao Lin, Pei Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
single-cell RNA sequencing
diabetic kidney disease
macrophages
efferocytosis
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1521554/full
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