Undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non-small cell lung carcinoma with pembrolizumab: a case report
Abstract Background Undifferentiated carcinoma of the colon is rare, and its prognosis is very poor. We report a case of undifferentiated carcinoma of the colon with rhabdoid features developed during treatment of non-small lung carcinoma (NSCLC) with pembrolizumab. Case presentation A 58-year-old m...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Japan Surgical Society
2020-08-01
|
| Series: | Surgical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40792-020-00963-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849416114488999936 |
|---|---|
| author | Yuya Ashitomi Mitsuhiro Yano Michihisa Kono Takefumi Suzuki Ichiro Kawamura Shinji Okazaki Yukinori Kamio Osamu Hachiya Yuka Urano Fuyuhiko Motoi |
| author_facet | Yuya Ashitomi Mitsuhiro Yano Michihisa Kono Takefumi Suzuki Ichiro Kawamura Shinji Okazaki Yukinori Kamio Osamu Hachiya Yuka Urano Fuyuhiko Motoi |
| author_sort | Yuya Ashitomi |
| collection | DOAJ |
| description | Abstract Background Undifferentiated carcinoma of the colon is rare, and its prognosis is very poor. We report a case of undifferentiated carcinoma of the colon with rhabdoid features developed during treatment of non-small lung carcinoma (NSCLC) with pembrolizumab. Case presentation A 58-year-old man was diagnosed with transverse colon cancer during chemotherapy with pembrolizumab for NSCLC. Laparoscopic right hemicolectomy was performed. The histopathological diagnosis was undifferentiated carcinoma with rhabdoid features and lymph node metastasis. Immunohistochemically, programmed death ligand 1 (PD-L1) showed positivity. The microsatellite instability (MSI) status was low. He continued to receive pembrolizumab for NSCLC, and there have been no signs of colon cancer recurrence and progression of NSCLC for 15 months. Conclusion We present the case of an undifferentiated carcinoma of the transverse colon with rhabdoid features. The development of the tumor with the expression of PD-L1 during pembrolizumab might have been associated with the low MSI. |
| format | Article |
| id | doaj-art-2062e3f08b9f4ee2862aa375181f88eb |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-2062e3f08b9f4ee2862aa375181f88eb2025-08-20T03:33:17ZengJapan Surgical SocietySurgical Case Reports2198-77932020-08-01611410.1186/s40792-020-00963-1Undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non-small cell lung carcinoma with pembrolizumab: a case reportYuya Ashitomi0Mitsuhiro Yano1Michihisa Kono2Takefumi Suzuki3Ichiro Kawamura4Shinji Okazaki5Yukinori Kamio6Osamu Hachiya7Yuka Urano8Fuyuhiko Motoi9First Department of Surgery, Yamagata University Faculty of MedicineFirst Department of Surgery, Yamagata University Faculty of MedicineFirst Department of Surgery, Yamagata University Faculty of MedicineFirst Department of Surgery, Yamagata University Faculty of MedicineFirst Department of Surgery, Yamagata University Faculty of MedicineFirst Department of Surgery, Yamagata University Faculty of MedicineFirst Department of Surgery, Yamagata University Faculty of MedicineFirst Department of Surgery, Yamagata University Faculty of MedicineDepartment of Pathological Diagnostics, Yamagata University Faculty of MedicineFirst Department of Surgery, Yamagata University Faculty of MedicineAbstract Background Undifferentiated carcinoma of the colon is rare, and its prognosis is very poor. We report a case of undifferentiated carcinoma of the colon with rhabdoid features developed during treatment of non-small lung carcinoma (NSCLC) with pembrolizumab. Case presentation A 58-year-old man was diagnosed with transverse colon cancer during chemotherapy with pembrolizumab for NSCLC. Laparoscopic right hemicolectomy was performed. The histopathological diagnosis was undifferentiated carcinoma with rhabdoid features and lymph node metastasis. Immunohistochemically, programmed death ligand 1 (PD-L1) showed positivity. The microsatellite instability (MSI) status was low. He continued to receive pembrolizumab for NSCLC, and there have been no signs of colon cancer recurrence and progression of NSCLC for 15 months. Conclusion We present the case of an undifferentiated carcinoma of the transverse colon with rhabdoid features. The development of the tumor with the expression of PD-L1 during pembrolizumab might have been associated with the low MSI.http://link.springer.com/article/10.1186/s40792-020-00963-1Colorectal cancerUndifferentiated carcinomaRhabdoid tumorPembrolizumab |
| spellingShingle | Yuya Ashitomi Mitsuhiro Yano Michihisa Kono Takefumi Suzuki Ichiro Kawamura Shinji Okazaki Yukinori Kamio Osamu Hachiya Yuka Urano Fuyuhiko Motoi Undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non-small cell lung carcinoma with pembrolizumab: a case report Surgical Case Reports Colorectal cancer Undifferentiated carcinoma Rhabdoid tumor Pembrolizumab |
| title | Undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non-small cell lung carcinoma with pembrolizumab: a case report |
| title_full | Undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non-small cell lung carcinoma with pembrolizumab: a case report |
| title_fullStr | Undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non-small cell lung carcinoma with pembrolizumab: a case report |
| title_full_unstemmed | Undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non-small cell lung carcinoma with pembrolizumab: a case report |
| title_short | Undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non-small cell lung carcinoma with pembrolizumab: a case report |
| title_sort | undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non small cell lung carcinoma with pembrolizumab a case report |
| topic | Colorectal cancer Undifferentiated carcinoma Rhabdoid tumor Pembrolizumab |
| url | http://link.springer.com/article/10.1186/s40792-020-00963-1 |
| work_keys_str_mv | AT yuyaashitomi undifferentiatedcarcinomaofthetransversecolonwithrhabdoidfeaturesthatdevelopedduringtreatmentofnonsmallcelllungcarcinomawithpembrolizumabacasereport AT mitsuhiroyano undifferentiatedcarcinomaofthetransversecolonwithrhabdoidfeaturesthatdevelopedduringtreatmentofnonsmallcelllungcarcinomawithpembrolizumabacasereport AT michihisakono undifferentiatedcarcinomaofthetransversecolonwithrhabdoidfeaturesthatdevelopedduringtreatmentofnonsmallcelllungcarcinomawithpembrolizumabacasereport AT takefumisuzuki undifferentiatedcarcinomaofthetransversecolonwithrhabdoidfeaturesthatdevelopedduringtreatmentofnonsmallcelllungcarcinomawithpembrolizumabacasereport AT ichirokawamura undifferentiatedcarcinomaofthetransversecolonwithrhabdoidfeaturesthatdevelopedduringtreatmentofnonsmallcelllungcarcinomawithpembrolizumabacasereport AT shinjiokazaki undifferentiatedcarcinomaofthetransversecolonwithrhabdoidfeaturesthatdevelopedduringtreatmentofnonsmallcelllungcarcinomawithpembrolizumabacasereport AT yukinorikamio undifferentiatedcarcinomaofthetransversecolonwithrhabdoidfeaturesthatdevelopedduringtreatmentofnonsmallcelllungcarcinomawithpembrolizumabacasereport AT osamuhachiya undifferentiatedcarcinomaofthetransversecolonwithrhabdoidfeaturesthatdevelopedduringtreatmentofnonsmallcelllungcarcinomawithpembrolizumabacasereport AT yukaurano undifferentiatedcarcinomaofthetransversecolonwithrhabdoidfeaturesthatdevelopedduringtreatmentofnonsmallcelllungcarcinomawithpembrolizumabacasereport AT fuyuhikomotoi undifferentiatedcarcinomaofthetransversecolonwithrhabdoidfeaturesthatdevelopedduringtreatmentofnonsmallcelllungcarcinomawithpembrolizumabacasereport |