Asymptomatic Localized Gastric Amyloidosis with Two Separate Lesions
Amyloidosis is a disease in which amyloid is abnormally accumulated in the tissue. The kidney and heart are the most commonly involved organs. Gastric involvement is relatively common in systemic disease; however, localized gastric amyloidosis is rare. Here, we report a case of localized gastric amy...
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Korean College of Helicobacter and Upper Gastrointestinal Research
2018-06-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
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| Online Access: | http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2018.18.2.131 |
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| author | Joo Hyun Lim Jung Kim Ji Yeon Seo Jung Ho Bae |
| author_facet | Joo Hyun Lim Jung Kim Ji Yeon Seo Jung Ho Bae |
| author_sort | Joo Hyun Lim |
| collection | DOAJ |
| description | Amyloidosis is a disease in which amyloid is abnormally accumulated in the tissue. The kidney and heart are the most commonly involved organs. Gastric involvement is relatively common in systemic disease; however, localized gastric amyloidosis is rare. Here, we report a case of localized gastric amyloidosis with two separate lesions. A 56-year-old woman underwent a health surveillance checkup without any noticeable symptoms. She was under medication for diabetes and dyslipidemia, and was otherwise healthy. On surveillance upper endoscopy, an irregularly shaped hyperemic elevated erosion at the gastric fundus and a 1.5-cm, yellowish subepithelial tumor-like lesion with intact overlying mucosa at the lesser curvature of the lower body of the stomach were detected. Endoscopic biopsy revealed submucosal eosinophilic material deposition in both lesions. Congo-red staining showed amyloid deposit appearing as a yellow-green birefringence under polarizing microscopy. Echocardiography, abdominal sonography, and colonoscopy revealed no abnormality. The patient was diagnosed as having localized gastric amyloidosis and is now undergoing regular follow-up without any treatment. Localized gastric amyloidosis is a rare disease that may mimic nonspecific gastritis or subepithelial tumor. However, endoscopic biopsy with appropriate staining may be diagnostic and thorough evaluation for systemic involvement is important. |
| format | Article |
| id | doaj-art-2057672abc24437ca304fbf1887883ba |
| institution | DOAJ |
| issn | 1738-3331 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-2057672abc24437ca304fbf1887883ba2025-08-20T02:42:07ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312018-06-0118213113410.7704/kjhugr.2018.18.2.131kjhugr.2018.18.2.131Asymptomatic Localized Gastric Amyloidosis with Two Separate LesionsJoo Hyun Lim0Jung Kim1Ji Yeon Seo2Jung Ho Bae3Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, KoreaDepartment of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, KoreaAmyloidosis is a disease in which amyloid is abnormally accumulated in the tissue. The kidney and heart are the most commonly involved organs. Gastric involvement is relatively common in systemic disease; however, localized gastric amyloidosis is rare. Here, we report a case of localized gastric amyloidosis with two separate lesions. A 56-year-old woman underwent a health surveillance checkup without any noticeable symptoms. She was under medication for diabetes and dyslipidemia, and was otherwise healthy. On surveillance upper endoscopy, an irregularly shaped hyperemic elevated erosion at the gastric fundus and a 1.5-cm, yellowish subepithelial tumor-like lesion with intact overlying mucosa at the lesser curvature of the lower body of the stomach were detected. Endoscopic biopsy revealed submucosal eosinophilic material deposition in both lesions. Congo-red staining showed amyloid deposit appearing as a yellow-green birefringence under polarizing microscopy. Echocardiography, abdominal sonography, and colonoscopy revealed no abnormality. The patient was diagnosed as having localized gastric amyloidosis and is now undergoing regular follow-up without any treatment. Localized gastric amyloidosis is a rare disease that may mimic nonspecific gastritis or subepithelial tumor. However, endoscopic biopsy with appropriate staining may be diagnostic and thorough evaluation for systemic involvement is important.http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2018.18.2.131AmyloidosisEndoscopyStomach |
| spellingShingle | Joo Hyun Lim Jung Kim Ji Yeon Seo Jung Ho Bae Asymptomatic Localized Gastric Amyloidosis with Two Separate Lesions The Korean Journal of Helicobacter and Upper Gastrointestinal Research Amyloidosis Endoscopy Stomach |
| title | Asymptomatic Localized Gastric Amyloidosis with Two Separate Lesions |
| title_full | Asymptomatic Localized Gastric Amyloidosis with Two Separate Lesions |
| title_fullStr | Asymptomatic Localized Gastric Amyloidosis with Two Separate Lesions |
| title_full_unstemmed | Asymptomatic Localized Gastric Amyloidosis with Two Separate Lesions |
| title_short | Asymptomatic Localized Gastric Amyloidosis with Two Separate Lesions |
| title_sort | asymptomatic localized gastric amyloidosis with two separate lesions |
| topic | Amyloidosis Endoscopy Stomach |
| url | http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2018.18.2.131 |
| work_keys_str_mv | AT joohyunlim asymptomaticlocalizedgastricamyloidosiswithtwoseparatelesions AT jungkim asymptomaticlocalizedgastricamyloidosiswithtwoseparatelesions AT jiyeonseo asymptomaticlocalizedgastricamyloidosiswithtwoseparatelesions AT junghobae asymptomaticlocalizedgastricamyloidosiswithtwoseparatelesions |