Do Lactation-Induced Changes in Ghrelin, Glucagon-Like Peptide-1, and Peptide YY Influence Appetite and Body Weight Regulation during the First Postpartum Year?
To determine whether fasting and meal-induced appetite-regulating hormones are altered during lactation and associated with body weight retention after childbearing, we studied 24 exclusively breastfeeding women (BMI = 25.2 ± 3.6 kg/m2) at 4-5 weeks postpartum and 20 never-pregnant controls (BMI = 2...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2016/7532926 |
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| author | D. Enette Larson-Meyer Jessica Schueler Erin Kyle Kathleen J. Austin Ann Marie Hart Brenda M. Alexander |
| author_facet | D. Enette Larson-Meyer Jessica Schueler Erin Kyle Kathleen J. Austin Ann Marie Hart Brenda M. Alexander |
| author_sort | D. Enette Larson-Meyer |
| collection | DOAJ |
| description | To determine whether fasting and meal-induced appetite-regulating hormones are altered during lactation and associated with body weight retention after childbearing, we studied 24 exclusively breastfeeding women (BMI = 25.2 ± 3.6 kg/m2) at 4-5 weeks postpartum and 20 never-pregnant controls (BMI = 24.0 ± 3.1 kg/m2). Ghrelin, PYY, GLP-1, and appetite ratings were measured before/and 150 minutes after a standardized breakfast and 60 minutes after an ad libitum lunch. Body weight/composition were measured at 6 and 12 months. Fasting and area under-the-curve responses for appetite-regulating hormones did not differ between lactating and control groups; ghrelinacyl, however, tended to track higher after the standardized breakfast in lactating women and was higher (p<0.05) after the ad libitum lunch despite a 24% higher energy intake (p < 0.05). By 12 months, lactating women lost 5.3 ± 2.2 kg (n=18), whereas control women (n=15) remained weight stable (p=0.019); fifteen of the lactating women returned to within ±2.0 kg of prepregnancy weight but three retained >6.0 kg. The retainers had greater (p<0.05) postmeal ghrelin rebound responses following breakfast. Overall these studies do not support the hypothesis that appetite-regulating hormones are altered during lactation and associated with postpartum weight retention. Altered ghrelin responses, however, deserve further exploration. |
| format | Article |
| id | doaj-art-20514f872dfd403ba89cd1558e850baa |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-20514f872dfd403ba89cd1558e850baa2025-02-03T05:46:39ZengWileyJournal of Obesity2090-07082090-07162016-01-01201610.1155/2016/75329267532926Do Lactation-Induced Changes in Ghrelin, Glucagon-Like Peptide-1, and Peptide YY Influence Appetite and Body Weight Regulation during the First Postpartum Year?D. Enette Larson-Meyer0Jessica Schueler1Erin Kyle2Kathleen J. Austin3Ann Marie Hart4Brenda M. Alexander5Department of Family and Consumer Sciences (Human Nutrition), University of Wyoming, Laramie, WY 82071, USADepartment of Family and Consumer Sciences (Human Nutrition), University of Wyoming, Laramie, WY 82071, USADepartment of Family and Consumer Sciences (Human Nutrition), University of Wyoming, Laramie, WY 82071, USADepartment of Animal Science, University of Wyoming, Laramie, WY 82071, USASchool of Nursing, University of Wyoming, Laramie, WY 82071, USADepartment of Animal Science, University of Wyoming, Laramie, WY 82071, USATo determine whether fasting and meal-induced appetite-regulating hormones are altered during lactation and associated with body weight retention after childbearing, we studied 24 exclusively breastfeeding women (BMI = 25.2 ± 3.6 kg/m2) at 4-5 weeks postpartum and 20 never-pregnant controls (BMI = 24.0 ± 3.1 kg/m2). Ghrelin, PYY, GLP-1, and appetite ratings were measured before/and 150 minutes after a standardized breakfast and 60 minutes after an ad libitum lunch. Body weight/composition were measured at 6 and 12 months. Fasting and area under-the-curve responses for appetite-regulating hormones did not differ between lactating and control groups; ghrelinacyl, however, tended to track higher after the standardized breakfast in lactating women and was higher (p<0.05) after the ad libitum lunch despite a 24% higher energy intake (p < 0.05). By 12 months, lactating women lost 5.3 ± 2.2 kg (n=18), whereas control women (n=15) remained weight stable (p=0.019); fifteen of the lactating women returned to within ±2.0 kg of prepregnancy weight but three retained >6.0 kg. The retainers had greater (p<0.05) postmeal ghrelin rebound responses following breakfast. Overall these studies do not support the hypothesis that appetite-regulating hormones are altered during lactation and associated with postpartum weight retention. Altered ghrelin responses, however, deserve further exploration.http://dx.doi.org/10.1155/2016/7532926 |
| spellingShingle | D. Enette Larson-Meyer Jessica Schueler Erin Kyle Kathleen J. Austin Ann Marie Hart Brenda M. Alexander Do Lactation-Induced Changes in Ghrelin, Glucagon-Like Peptide-1, and Peptide YY Influence Appetite and Body Weight Regulation during the First Postpartum Year? Journal of Obesity |
| title | Do Lactation-Induced Changes in Ghrelin, Glucagon-Like Peptide-1, and Peptide YY Influence Appetite and Body Weight Regulation during the First Postpartum Year? |
| title_full | Do Lactation-Induced Changes in Ghrelin, Glucagon-Like Peptide-1, and Peptide YY Influence Appetite and Body Weight Regulation during the First Postpartum Year? |
| title_fullStr | Do Lactation-Induced Changes in Ghrelin, Glucagon-Like Peptide-1, and Peptide YY Influence Appetite and Body Weight Regulation during the First Postpartum Year? |
| title_full_unstemmed | Do Lactation-Induced Changes in Ghrelin, Glucagon-Like Peptide-1, and Peptide YY Influence Appetite and Body Weight Regulation during the First Postpartum Year? |
| title_short | Do Lactation-Induced Changes in Ghrelin, Glucagon-Like Peptide-1, and Peptide YY Influence Appetite and Body Weight Regulation during the First Postpartum Year? |
| title_sort | do lactation induced changes in ghrelin glucagon like peptide 1 and peptide yy influence appetite and body weight regulation during the first postpartum year |
| url | http://dx.doi.org/10.1155/2016/7532926 |
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