Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats
Pyruvate is an endogenous antioxidant substance. The aim of this study was to investigate the protective effects of ethyl pyruvate (EP) on retinal vascular injury in diabetic retinopathy. To investigate the protective effect of EP on vascular cell apoptosis and blood-retinal barrier (BRB) breakage,...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/460820 |
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| author | Junghyun Kim Yun Mi Lee Chan-Sik Kim Eunjin Sohn Kyuhyung Jo So Dam Shin Jin Sook Kim |
| author_facet | Junghyun Kim Yun Mi Lee Chan-Sik Kim Eunjin Sohn Kyuhyung Jo So Dam Shin Jin Sook Kim |
| author_sort | Junghyun Kim |
| collection | DOAJ |
| description | Pyruvate is an endogenous antioxidant substance. The aim of this study was to investigate the protective effects of ethyl pyruvate (EP) on retinal vascular injury in diabetic retinopathy. To investigate the protective effect of EP on vascular cell apoptosis and blood-retinal barrier (BRB) breakage, we have used intravitreally methylglyoxal-(MGO-) injected rat eyes. Apoptosis of the retinal vascular cell that was stimulated by the intravitreal injection of MGO was evidently attenuated by the EP treatment. EP exerts inhibitory effect on MGO-induced vascular cell apoptosis by blocking oxidative injury. In addition, EP treatment prevented MGO-induced BRB breakage and the degradation of occludin, an important tight junction protein. These observations suggest that EP acts through an antioxidant mechanism to protect against oxidative stress-induced apoptosis in retinal vessels. |
| format | Article |
| id | doaj-art-2049753537eb4c0b9de940ff23f1cdfb |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-2049753537eb4c0b9de940ff23f1cdfb2025-08-20T02:04:33ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/460820460820Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in RatsJunghyun Kim0Yun Mi Lee1Chan-Sik Kim2Eunjin Sohn3Kyuhyung Jo4So Dam Shin5Jin Sook Kim6Korean Medicine Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdaero, Yuseong-gu, Daejeon 305-811, Republic of KoreaKorean Medicine Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdaero, Yuseong-gu, Daejeon 305-811, Republic of KoreaKorean Medicine Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdaero, Yuseong-gu, Daejeon 305-811, Republic of KoreaKorean Medicine Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdaero, Yuseong-gu, Daejeon 305-811, Republic of KoreaKorean Medicine Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdaero, Yuseong-gu, Daejeon 305-811, Republic of KoreaKorean Medicine Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdaero, Yuseong-gu, Daejeon 305-811, Republic of KoreaKorean Medicine Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdaero, Yuseong-gu, Daejeon 305-811, Republic of KoreaPyruvate is an endogenous antioxidant substance. The aim of this study was to investigate the protective effects of ethyl pyruvate (EP) on retinal vascular injury in diabetic retinopathy. To investigate the protective effect of EP on vascular cell apoptosis and blood-retinal barrier (BRB) breakage, we have used intravitreally methylglyoxal-(MGO-) injected rat eyes. Apoptosis of the retinal vascular cell that was stimulated by the intravitreal injection of MGO was evidently attenuated by the EP treatment. EP exerts inhibitory effect on MGO-induced vascular cell apoptosis by blocking oxidative injury. In addition, EP treatment prevented MGO-induced BRB breakage and the degradation of occludin, an important tight junction protein. These observations suggest that EP acts through an antioxidant mechanism to protect against oxidative stress-induced apoptosis in retinal vessels.http://dx.doi.org/10.1155/2013/460820 |
| spellingShingle | Junghyun Kim Yun Mi Lee Chan-Sik Kim Eunjin Sohn Kyuhyung Jo So Dam Shin Jin Sook Kim Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats Journal of Diabetes Research |
| title | Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats |
| title_full | Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats |
| title_fullStr | Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats |
| title_full_unstemmed | Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats |
| title_short | Ethyl Pyruvate Prevents Methyglyoxal-Induced Retinal Vascular Injury in Rats |
| title_sort | ethyl pyruvate prevents methyglyoxal induced retinal vascular injury in rats |
| url | http://dx.doi.org/10.1155/2013/460820 |
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