The role of BATF in immune cell differentiation and autoimmune diseases
Abstract As a member of the Activator Protein-1 (AP-1) transcription factor family, the Basic Leucine Zipper Transcription Factor (BATF) mediates multiple biological functions of immune cells through its involvement in protein interactions and binding to DNA. Recent studies have demonstrated that BA...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Biomarker Research |
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| Online Access: | https://doi.org/10.1186/s40364-025-00733-x |
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| author | Xiaomeng Wang Yue Hong Jinmei Zou Bo Zhu Chao Jiang Liwei Lu Jie Tian Jing Yang Ke Rui |
| author_facet | Xiaomeng Wang Yue Hong Jinmei Zou Bo Zhu Chao Jiang Liwei Lu Jie Tian Jing Yang Ke Rui |
| author_sort | Xiaomeng Wang |
| collection | DOAJ |
| description | Abstract As a member of the Activator Protein-1 (AP-1) transcription factor family, the Basic Leucine Zipper Transcription Factor (BATF) mediates multiple biological functions of immune cells through its involvement in protein interactions and binding to DNA. Recent studies have demonstrated that BATF not only plays pivotal roles in innate and adaptive immune responses but also acts as a crucial factor in the differentiation and function of various immune cells. Lines of evidence indicate that BATF is associated with the onset and progression of allergic diseases, graft-versus-host disease, tumors, and autoimmune diseases. This review summarizes the roles of BATF in the development and function of innate and adaptive immune cells, as well as its immunoregulatory effects in the development of autoimmune diseases, which may enhance the current understanding of the pathogenesis of autoimmune diseases and facilitate the development of new therapeutic strategies. |
| format | Article |
| id | doaj-art-20467e05506340cfae653e6fde48d38b |
| institution | Kabale University |
| issn | 2050-7771 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj-art-20467e05506340cfae653e6fde48d38b2025-02-02T12:35:28ZengBMCBiomarker Research2050-77712025-01-0113111610.1186/s40364-025-00733-xThe role of BATF in immune cell differentiation and autoimmune diseasesXiaomeng Wang0Yue Hong1Jinmei Zou2Bo Zhu3Chao Jiang4Liwei Lu5Jie Tian6Jing Yang7Ke Rui8Department of Laboratory Medicine, Institute of Medical Immunology, Affiliated Hospital of Jiangsu UniversityDepartment of Hematology and Oncology, Children’s Hospital of Nanjing Medical UniversityDepartment of Rheumatology, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaDepartment of Laboratory Medicine, Institute of Medical Immunology, Affiliated Hospital of Jiangsu UniversityDepartment of Orthopaedics, Affiliated Hospital of Jiangsu UniversityDepartment of Pathology, Shenzhen Institute of Research and Innovation, The University of Hong KongDepartment of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu UniversityDepartment of Rheumatology, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of ChinaDepartment of Laboratory Medicine, Institute of Medical Immunology, Affiliated Hospital of Jiangsu UniversityAbstract As a member of the Activator Protein-1 (AP-1) transcription factor family, the Basic Leucine Zipper Transcription Factor (BATF) mediates multiple biological functions of immune cells through its involvement in protein interactions and binding to DNA. Recent studies have demonstrated that BATF not only plays pivotal roles in innate and adaptive immune responses but also acts as a crucial factor in the differentiation and function of various immune cells. Lines of evidence indicate that BATF is associated with the onset and progression of allergic diseases, graft-versus-host disease, tumors, and autoimmune diseases. This review summarizes the roles of BATF in the development and function of innate and adaptive immune cells, as well as its immunoregulatory effects in the development of autoimmune diseases, which may enhance the current understanding of the pathogenesis of autoimmune diseases and facilitate the development of new therapeutic strategies.https://doi.org/10.1186/s40364-025-00733-xBATFImmune cellAutoimmune diseaseImmunomodulationAutoimmunity |
| spellingShingle | Xiaomeng Wang Yue Hong Jinmei Zou Bo Zhu Chao Jiang Liwei Lu Jie Tian Jing Yang Ke Rui The role of BATF in immune cell differentiation and autoimmune diseases Biomarker Research BATF Immune cell Autoimmune disease Immunomodulation Autoimmunity |
| title | The role of BATF in immune cell differentiation and autoimmune diseases |
| title_full | The role of BATF in immune cell differentiation and autoimmune diseases |
| title_fullStr | The role of BATF in immune cell differentiation and autoimmune diseases |
| title_full_unstemmed | The role of BATF in immune cell differentiation and autoimmune diseases |
| title_short | The role of BATF in immune cell differentiation and autoimmune diseases |
| title_sort | role of batf in immune cell differentiation and autoimmune diseases |
| topic | BATF Immune cell Autoimmune disease Immunomodulation Autoimmunity |
| url | https://doi.org/10.1186/s40364-025-00733-x |
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