Correlation between Insulin antibodyand HbA1c in Diabetes Mellitus
Insulin antibodies (INAs) are found in both types of diabetic patients and have low binding capacity and high affinity leading to hypoglycemia or hyperglycemia in type II patients taking insulin, which differs from the insulin antibodies found in type I that contain a high capacity of insulin bind...
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University of Thi-Qar
2024-12-01
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| Series: | مجلة علوم ذي قار |
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| Online Access: | https://jsci.utq.edu.iq/index.php/main/article/view/1242 |
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| author | Joumana Sharad Hind Mousa |
| author_facet | Joumana Sharad Hind Mousa |
| author_sort | Joumana Sharad |
| collection | DOAJ |
| description | Insulin antibodies (INAs) are found in both types of diabetic patients and have low binding capacity and high affinity leading to hypoglycemia or hyperglycemia in type II patients taking insulin, which differs from the insulin antibodies found in type I that contain a high capacity of insulin binding and low affinity. This work aims to detect the levels of insulin antibodies and HbA1c in diabetic patients, and find the correlation between them and its potential role in glucose control. The study involved 60 patients with diabetes, divided into two groups type I and type II, each group containing 30 patients, in addition to 30 healthy individuals as a control group. High-performance liquid chromatography in a D-10 analyzer was used to measure HbA1c while ELISA was used to measure INAs in control and patients .Results: The current finding showed significant an elevated mean levels of HbA1c and INAs in both of patients groups compare to healthy, and there was non-significant weak positive correlation between them (R= 0.107 , P= 0.4 ).Together, elevated levels of HbA1c and INA, and the positive correlation between their levels, provide evidence of the effect of insulin antibodies on glycemic control and the effects of HbA1c levels in patients with diabetes.
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| format | Article |
| id | doaj-art-20466efcbb584a86a025a4a8ce12d1f7 |
| institution | DOAJ |
| issn | 1991-8690 2709-0256 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | University of Thi-Qar |
| record_format | Article |
| series | مجلة علوم ذي قار |
| spelling | doaj-art-20466efcbb584a86a025a4a8ce12d1f72025-08-20T02:58:26ZengUniversity of Thi-Qarمجلة علوم ذي قار1991-86902709-02562024-12-0111210.32792/utq/utjsci/v11i2.1242Correlation between Insulin antibodyand HbA1c in Diabetes MellitusJoumana Sharad0Hind Mousa1Pathological Analysis Department, Collegeof science,Universityof Thi-QarPathological Analysis Department, Collegeof science,Universityof Thi-Qar Insulin antibodies (INAs) are found in both types of diabetic patients and have low binding capacity and high affinity leading to hypoglycemia or hyperglycemia in type II patients taking insulin, which differs from the insulin antibodies found in type I that contain a high capacity of insulin binding and low affinity. This work aims to detect the levels of insulin antibodies and HbA1c in diabetic patients, and find the correlation between them and its potential role in glucose control. The study involved 60 patients with diabetes, divided into two groups type I and type II, each group containing 30 patients, in addition to 30 healthy individuals as a control group. High-performance liquid chromatography in a D-10 analyzer was used to measure HbA1c while ELISA was used to measure INAs in control and patients .Results: The current finding showed significant an elevated mean levels of HbA1c and INAs in both of patients groups compare to healthy, and there was non-significant weak positive correlation between them (R= 0.107 , P= 0.4 ).Together, elevated levels of HbA1c and INA, and the positive correlation between their levels, provide evidence of the effect of insulin antibodies on glycemic control and the effects of HbA1c levels in patients with diabetes. https://jsci.utq.edu.iq/index.php/main/article/view/1242: Insulin antibody , HbA1c , poor glycemic control |
| spellingShingle | Joumana Sharad Hind Mousa Correlation between Insulin antibodyand HbA1c in Diabetes Mellitus مجلة علوم ذي قار : Insulin antibody , HbA1c , poor glycemic control |
| title | Correlation between Insulin antibodyand HbA1c in Diabetes Mellitus |
| title_full | Correlation between Insulin antibodyand HbA1c in Diabetes Mellitus |
| title_fullStr | Correlation between Insulin antibodyand HbA1c in Diabetes Mellitus |
| title_full_unstemmed | Correlation between Insulin antibodyand HbA1c in Diabetes Mellitus |
| title_short | Correlation between Insulin antibodyand HbA1c in Diabetes Mellitus |
| title_sort | correlation between insulin antibodyand hba1c in diabetes mellitus |
| topic | : Insulin antibody , HbA1c , poor glycemic control |
| url | https://jsci.utq.edu.iq/index.php/main/article/view/1242 |
| work_keys_str_mv | AT joumanasharad correlationbetweeninsulinantibodyandhba1cindiabetesmellitus AT hindmousa correlationbetweeninsulinantibodyandhba1cindiabetesmellitus |