The effect and mechanism of Germacrone in ameliorating alcoholic fatty liver by inhibiting Nrf2/Rbp4

The effect and mechanism of Germacrone in ameliorating alcoholic fatty liver by inhibiting Nrf2/Rbp4

Abstract Background Alcohol-related liver disease (ALD) is an important cause of the increase in liver disease-related morbidity and mortality worldwide. Its core pathological features are oxidative stress imbalance and lipid metabolism disorders. Nuclear factor E2-related factor 2 (Nrf2), a key reg...

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Main Authors: Ru Xiao, Jiamin Fang, Qinpo Huang, Guolin He, Xia Ou, Yang De, Shuhua Gui, Yun Zhang, Maoci Wang, Yiyuan Zhong, Dawa Zeren, Yongling Long, Changhui Liu, Tianqin Xiong
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Chinese Medicine
Subjects:
Germacrone
Alcoholic liver disease
Oxidative stress
Nrf2
Rbp4
Lipid metabolism
Online Access:https://doi.org/10.1186/s13020-025-01132-y
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