Association between dyslipidemia and elevated liver enzymes: A cross-sectional study from the PERSIAN Guilan cohort study
Background: Dyslipidemia is associated with several health complications that put a heavy burden on the healthcare system and society due to its adverse outcomes. Abnormal lipid profile is known to cause complications in hepatic systems. The aim of this study was to examine the associations of eleva...
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Elsevier
2025-12-01
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| Series: | Endocrine and Metabolic Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666396125000585 |
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| author | Milad Shahdkar Mahdi Orang Goorabzarmakhi Mahdi Shafizadeh Farahnaz Joukar Saman Maroufizadeh Niloofar Faraji Tahereh Zeinali Fariborz Mansour-Ghanaei |
| author_facet | Milad Shahdkar Mahdi Orang Goorabzarmakhi Mahdi Shafizadeh Farahnaz Joukar Saman Maroufizadeh Niloofar Faraji Tahereh Zeinali Fariborz Mansour-Ghanaei |
| author_sort | Milad Shahdkar |
| collection | DOAJ |
| description | Background: Dyslipidemia is associated with several health complications that put a heavy burden on the healthcare system and society due to its adverse outcomes. Abnormal lipid profile is known to cause complications in hepatic systems. The aim of this study was to examine the associations of elevated liver enzymes with dyslipidemia and its components in the Prospective Epidemiological Research Studies (PERSIAN) Guilan Cohort study (PGCS) population. Methods: This cross-sectional study was conducted on data from 10,520 participants in PGCS, Guilan province, Iran. The demographic data and clinical characteristics of the participants were recorded. Lipid profile of the participants, including total cholesterol (Chol), triglycerides (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL); and liver enzymes levels including alanine and aspartate aminotransferase (ALT, AST), γ-glutamyltransferase (GGT) and alkaline phosphatase (ALP) were measured. Statistical analyses were performed using SPSS version 16 based on a significant level < 0.05. Results: Of 10,520 participants, 53.6 % (n = 5633) were female, and 36.6 % were aged 45–54. The mean BMI of the participants was 28.14 kg/m2. The prevalence of alcohol consumption, fatty liver disease, hepatitis, lipid-lowering medication use, and hepatotoxic drug use were 13.3 %, 0.6 %, 0.3 %, 15.1 %, and 16.5 %, respectively. Abnormal levels of Chol, TG, LDL, HDL, ALT, AST, GGT, and ALP were reported in 40.3 %, 43.1 %, 29.0 %,41.5 %, 19.4 %, 4.6 %, 11.6 %, and 5.1 % individuals, respectively. Dyslipidemia significantly increased the likelihood of elevated ALT, AST, and GGT (P < 0.05), but showed no statistically significant association with elevated ALP (P > 0.05). High Chol, TG, and LDL were strongly associated with elevated liver enzymes, particularly ALT and GGT, while low HDL was less impactful. Conclusion: These results underscore the significant impact of lipid abnormalities on liver function tests, especially for ALT and GGT. |
| format | Article |
| id | doaj-art-204022d64b4c42308cf7f8cfe46e6df2 |
| institution | DOAJ |
| issn | 2666-3961 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Endocrine and Metabolic Science |
| spelling | doaj-art-204022d64b4c42308cf7f8cfe46e6df22025-08-20T03:07:17ZengElsevierEndocrine and Metabolic Science2666-39612025-12-011910027210.1016/j.endmts.2025.100272Association between dyslipidemia and elevated liver enzymes: A cross-sectional study from the PERSIAN Guilan cohort studyMilad Shahdkar0Mahdi Orang Goorabzarmakhi1Mahdi Shafizadeh2Farahnaz Joukar3Saman Maroufizadeh4Niloofar Faraji5Tahereh Zeinali6Fariborz Mansour-Ghanaei7Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, IranGastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, IranGastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, IranGastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; Corresponding authors.Department of Biostatistics, School of Health, Guilan University of Medical Sciences, Rasht, IranGastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, IranGastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, IranGastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran; Corresponding authors.Background: Dyslipidemia is associated with several health complications that put a heavy burden on the healthcare system and society due to its adverse outcomes. Abnormal lipid profile is known to cause complications in hepatic systems. The aim of this study was to examine the associations of elevated liver enzymes with dyslipidemia and its components in the Prospective Epidemiological Research Studies (PERSIAN) Guilan Cohort study (PGCS) population. Methods: This cross-sectional study was conducted on data from 10,520 participants in PGCS, Guilan province, Iran. The demographic data and clinical characteristics of the participants were recorded. Lipid profile of the participants, including total cholesterol (Chol), triglycerides (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL); and liver enzymes levels including alanine and aspartate aminotransferase (ALT, AST), γ-glutamyltransferase (GGT) and alkaline phosphatase (ALP) were measured. Statistical analyses were performed using SPSS version 16 based on a significant level < 0.05. Results: Of 10,520 participants, 53.6 % (n = 5633) were female, and 36.6 % were aged 45–54. The mean BMI of the participants was 28.14 kg/m2. The prevalence of alcohol consumption, fatty liver disease, hepatitis, lipid-lowering medication use, and hepatotoxic drug use were 13.3 %, 0.6 %, 0.3 %, 15.1 %, and 16.5 %, respectively. Abnormal levels of Chol, TG, LDL, HDL, ALT, AST, GGT, and ALP were reported in 40.3 %, 43.1 %, 29.0 %,41.5 %, 19.4 %, 4.6 %, 11.6 %, and 5.1 % individuals, respectively. Dyslipidemia significantly increased the likelihood of elevated ALT, AST, and GGT (P < 0.05), but showed no statistically significant association with elevated ALP (P > 0.05). High Chol, TG, and LDL were strongly associated with elevated liver enzymes, particularly ALT and GGT, while low HDL was less impactful. Conclusion: These results underscore the significant impact of lipid abnormalities on liver function tests, especially for ALT and GGT.http://www.sciencedirect.com/science/article/pii/S2666396125000585DyslipidemiaLiver enzymesCardiovascular disease |
| spellingShingle | Milad Shahdkar Mahdi Orang Goorabzarmakhi Mahdi Shafizadeh Farahnaz Joukar Saman Maroufizadeh Niloofar Faraji Tahereh Zeinali Fariborz Mansour-Ghanaei Association between dyslipidemia and elevated liver enzymes: A cross-sectional study from the PERSIAN Guilan cohort study Endocrine and Metabolic Science Dyslipidemia Liver enzymes Cardiovascular disease |
| title | Association between dyslipidemia and elevated liver enzymes: A cross-sectional study from the PERSIAN Guilan cohort study |
| title_full | Association between dyslipidemia and elevated liver enzymes: A cross-sectional study from the PERSIAN Guilan cohort study |
| title_fullStr | Association between dyslipidemia and elevated liver enzymes: A cross-sectional study from the PERSIAN Guilan cohort study |
| title_full_unstemmed | Association between dyslipidemia and elevated liver enzymes: A cross-sectional study from the PERSIAN Guilan cohort study |
| title_short | Association between dyslipidemia and elevated liver enzymes: A cross-sectional study from the PERSIAN Guilan cohort study |
| title_sort | association between dyslipidemia and elevated liver enzymes a cross sectional study from the persian guilan cohort study |
| topic | Dyslipidemia Liver enzymes Cardiovascular disease |
| url | http://www.sciencedirect.com/science/article/pii/S2666396125000585 |
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