Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women
Background/Aim. Despite vitamin D insufficiency being widely reported, in Serbia the epidemiological data lack information regarding vitamin D status in the sera of postmenopausal women. The aim of this study was to establish the prevalence of inadequate serum 25-hydroxyvitamin D [25(OH)D] conce...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2012-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2012/0042-84501203243V.pdf |
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| author | Vučeljić Marina Ilić-Stojanović Olivera Lazović Milica Grajić Mirko |
| author_facet | Vučeljić Marina Ilić-Stojanović Olivera Lazović Milica Grajić Mirko |
| author_sort | Vučeljić Marina |
| collection | DOAJ |
| description | Background/Aim. Despite vitamin D insufficiency being widely reported, in Serbia the epidemiological data lack information regarding vitamin D status in the sera of postmenopausal women. The aim of this study was to establish the prevalence of inadequate serum 25-hydroxyvitamin D [25(OH)D] concentrations in postmenopausal Serbian women with seasonal variations of 25(OH)D, in relation to parathyroid hormone (PTH) and bone mineral density (BMD). Methods. A total of 95 postmenopausal women, mean age 65.1 ± 9.08 years, were examined. Measurements of 25(OH)D and PTH were performed both in the winter and the summer period, using electrochemiluminiscence immunoassays. BMD (g/cm2) was measured by the dualenergy x-Ray absortimetry (DXA) method on the spine and hip areas. Results. A decreased value of vitamin D (< 75 nmol/L) in 88.4% of postmenopausal women and an elevated level of PTH (> 65 pg/mL) in 25.3% of the cases were found. Elevated PTH varied individually, but was mostly increased if 25(OH)D was equal or lower than 37.6 nmol/L. 25(OH)D insufficiency was found in winter in 94.5% and in summer in 80% of the cases (p < 0.01). The mean of the PTH was higher (p < 0.05) in winter than in summer. A significant negative correlation between 25(OH)D and PTH (p < 0.001) was proved. Correlation between 25(OH)D and PTH with BMD at lumbar spine was established in the whole group, but at the femoral neck in women aged over 65 years (p < 0.05). Conclusion. Our results showed a high prevalence of vitamin D insufficiency (88.4%) among postmenopausal women. The levels of 25(OH)D and PTH changed significantly according to the season. |
| format | Article |
| id | doaj-art-203f2d5eecf947c5b6af874c4ae21f80 |
| institution | Kabale University |
| issn | 0042-8450 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-203f2d5eecf947c5b6af874c4ae21f802025-08-20T03:54:52ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502012-01-0169324324810.2298/VSP1203243VVitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal womenVučeljić MarinaIlić-Stojanović OliveraLazović MilicaGrajić MirkoBackground/Aim. Despite vitamin D insufficiency being widely reported, in Serbia the epidemiological data lack information regarding vitamin D status in the sera of postmenopausal women. The aim of this study was to establish the prevalence of inadequate serum 25-hydroxyvitamin D [25(OH)D] concentrations in postmenopausal Serbian women with seasonal variations of 25(OH)D, in relation to parathyroid hormone (PTH) and bone mineral density (BMD). Methods. A total of 95 postmenopausal women, mean age 65.1 ± 9.08 years, were examined. Measurements of 25(OH)D and PTH were performed both in the winter and the summer period, using electrochemiluminiscence immunoassays. BMD (g/cm2) was measured by the dualenergy x-Ray absortimetry (DXA) method on the spine and hip areas. Results. A decreased value of vitamin D (< 75 nmol/L) in 88.4% of postmenopausal women and an elevated level of PTH (> 65 pg/mL) in 25.3% of the cases were found. Elevated PTH varied individually, but was mostly increased if 25(OH)D was equal or lower than 37.6 nmol/L. 25(OH)D insufficiency was found in winter in 94.5% and in summer in 80% of the cases (p < 0.01). The mean of the PTH was higher (p < 0.05) in winter than in summer. A significant negative correlation between 25(OH)D and PTH (p < 0.001) was proved. Correlation between 25(OH)D and PTH with BMD at lumbar spine was established in the whole group, but at the femoral neck in women aged over 65 years (p < 0.05). Conclusion. Our results showed a high prevalence of vitamin D insufficiency (88.4%) among postmenopausal women. The levels of 25(OH)D and PTH changed significantly according to the season.http://www.doiserbia.nb.rs/img/doi/0042-8450/2012/0042-84501203243V.pdfvitamin Dparathyroid hormonebone densitypostmenopause |
| spellingShingle | Vučeljić Marina Ilić-Stojanović Olivera Lazović Milica Grajić Mirko Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women Vojnosanitetski Pregled vitamin D parathyroid hormone bone density postmenopause |
| title | Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women |
| title_full | Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women |
| title_fullStr | Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women |
| title_full_unstemmed | Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women |
| title_short | Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women |
| title_sort | vitamin d and parathyroid hormone in relation to bone mineral density in postmenopausal women |
| topic | vitamin D parathyroid hormone bone density postmenopause |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2012/0042-84501203243V.pdf |
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