Formulation of ophtalmic vitamin A nanoemulsion with Kolliphor® EL as surfactant and transcutol as cosurfactant and hen’s egg test chorioallantoic membrane (HET CAM) irritation test
Conventional eye drop preparations are the main choice for the treatment of eye disorders; however, they have low penetration and bioavailability. Vitamin A is nonphotostable, lipophilic, and easily degraded in the presence of oxygen. This study aimed to characterize a vitamin A ophthalmic nanoemuls...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2024-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2024/67/bioconf_icobeaf2024_04018.pdf |
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| author | Fatmawati Fatimah Siti Saras Sukmaningrum Galuh Vanda Pertiwi Deasy Efiana Nuri Ari |
| author_facet | Fatmawati Fatimah Siti Saras Sukmaningrum Galuh Vanda Pertiwi Deasy Efiana Nuri Ari |
| author_sort | Fatmawati Fatimah Siti |
| collection | DOAJ |
| description | Conventional eye drop preparations are the main choice for the treatment of eye disorders; however, they have low penetration and bioavailability. Vitamin A is nonphotostable, lipophilic, and easily degraded in the presence of oxygen. This study aimed to characterize a vitamin A ophthalmic nanoemulsion without any irritation. The nanoemulsion was prepared using a mixture of surfactant Kolliphor® EL and cosurfactant Transcutol (Smix) for F1 (1:1), F2 (1:2), and F3 (2:1). The formulas were examined by pH, optical transmission, refractive index, particle size, PDI, and Hen’s Egg Test Chorioallantoic Membrane (HET-CAM) irritation tests. The selected formula was F3, with the best optical transmission (97.35 ± 0.173%), pH (4.94 ± 0.04), refractive index (1.3534 ± 0.0002), particle size (24.47 ± 1.888 nm), PDI (0.353 ± 0.02), and no irritation response. This formula shows a good potential for ophthalmic eye drop preparation. |
| format | Article |
| id | doaj-art-203e0bb55d824ce2b79aea910598ae65 |
| institution | Kabale University |
| issn | 2117-4458 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-203e0bb55d824ce2b79aea910598ae652025-01-16T11:19:46ZengEDP SciencesBIO Web of Conferences2117-44582024-01-011480401810.1051/bioconf/202414804018bioconf_icobeaf2024_04018Formulation of ophtalmic vitamin A nanoemulsion with Kolliphor® EL as surfactant and transcutol as cosurfactant and hen’s egg test chorioallantoic membrane (HET CAM) irritation testFatmawati Fatimah Siti0Saras Sukmaningrum Galuh1Vanda Pertiwi Deasy2Efiana Nuri Ari3Department Pharmaceutics and Pharmaceutical Technology, Universitas Ahmad DahlanDepartment Pharmaceutics and Pharmaceutical Technology, Universitas Ahmad DahlanDepartment Pharmaceutics and Pharmaceutical Technology, Universitas Ahmad DahlanDepartment Pharmaceutics and Pharmaceutical Technology, Universitas Ahmad DahlanConventional eye drop preparations are the main choice for the treatment of eye disorders; however, they have low penetration and bioavailability. Vitamin A is nonphotostable, lipophilic, and easily degraded in the presence of oxygen. This study aimed to characterize a vitamin A ophthalmic nanoemulsion without any irritation. The nanoemulsion was prepared using a mixture of surfactant Kolliphor® EL and cosurfactant Transcutol (Smix) for F1 (1:1), F2 (1:2), and F3 (2:1). The formulas were examined by pH, optical transmission, refractive index, particle size, PDI, and Hen’s Egg Test Chorioallantoic Membrane (HET-CAM) irritation tests. The selected formula was F3, with the best optical transmission (97.35 ± 0.173%), pH (4.94 ± 0.04), refractive index (1.3534 ± 0.0002), particle size (24.47 ± 1.888 nm), PDI (0.353 ± 0.02), and no irritation response. This formula shows a good potential for ophthalmic eye drop preparation.https://www.bio-conferences.org/articles/bioconf/pdf/2024/67/bioconf_icobeaf2024_04018.pdf |
| spellingShingle | Fatmawati Fatimah Siti Saras Sukmaningrum Galuh Vanda Pertiwi Deasy Efiana Nuri Ari Formulation of ophtalmic vitamin A nanoemulsion with Kolliphor® EL as surfactant and transcutol as cosurfactant and hen’s egg test chorioallantoic membrane (HET CAM) irritation test BIO Web of Conferences |
| title | Formulation of ophtalmic vitamin A nanoemulsion with Kolliphor® EL as surfactant and transcutol as cosurfactant and hen’s egg test chorioallantoic membrane (HET CAM) irritation test |
| title_full | Formulation of ophtalmic vitamin A nanoemulsion with Kolliphor® EL as surfactant and transcutol as cosurfactant and hen’s egg test chorioallantoic membrane (HET CAM) irritation test |
| title_fullStr | Formulation of ophtalmic vitamin A nanoemulsion with Kolliphor® EL as surfactant and transcutol as cosurfactant and hen’s egg test chorioallantoic membrane (HET CAM) irritation test |
| title_full_unstemmed | Formulation of ophtalmic vitamin A nanoemulsion with Kolliphor® EL as surfactant and transcutol as cosurfactant and hen’s egg test chorioallantoic membrane (HET CAM) irritation test |
| title_short | Formulation of ophtalmic vitamin A nanoemulsion with Kolliphor® EL as surfactant and transcutol as cosurfactant and hen’s egg test chorioallantoic membrane (HET CAM) irritation test |
| title_sort | formulation of ophtalmic vitamin a nanoemulsion with kolliphor r el as surfactant and transcutol as cosurfactant and hen s egg test chorioallantoic membrane het cam irritation test |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2024/67/bioconf_icobeaf2024_04018.pdf |
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