Smoking and Breast Cancer Recurrence after Breast Conservation Therapy
Background. Prior studies have shown earlier recurrence and decreased survival in patients with head and neck cancer who smoked while undergoing radiation therapy. The purpose of the current study was to determine whether smoking status at the time of partial mastectomy and radiation therapy for bre...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2014/327081 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849307063915642880 |
|---|---|
| author | Jennifer D. Bishop Brigid K. Killelea Anees B. Chagpar Nina R. Horowitz Donald R. Lannin |
| author_facet | Jennifer D. Bishop Brigid K. Killelea Anees B. Chagpar Nina R. Horowitz Donald R. Lannin |
| author_sort | Jennifer D. Bishop |
| collection | DOAJ |
| description | Background. Prior studies have shown earlier recurrence and decreased survival in patients with head and neck cancer who smoked while undergoing radiation therapy. The purpose of the current study was to determine whether smoking status at the time of partial mastectomy and radiation therapy for breast cancer affected recurrence or survival. Method. A single institution retrospective chart review was performed to correlate smoking status with patient demographics, tumor characteristics, and outcomes for patients undergoing partial mastectomy and radiation therapy. Results. There were 624 patients who underwent breast conservation surgery between 2002 and 2010 for whom smoking history and follow-up data were available. Smoking status was associated with race, patient age, and tumor stage, but not with grade, histology, or receptor status. African American women were more likely to be current smokers (22% versus 7%, P<0.001). With a mean follow-up of 45 months, recurrence was significantly higher in current smokers compared to former or never smokers (P=0.039). In a multivariate model adjusted for race and tumor stage, recurrence among current smokers was 6.7 times that of never smokers (CI 2.0–22.4). Conclusions. Although the numbers are small, this study suggests that smoking may negatively influence recurrence rates after partial mastectomy and radiation therapy. A larger study is needed to confirm these observations. |
| format | Article |
| id | doaj-art-203e0603561b4eabb39a96e3283a5812 |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-203e0603561b4eabb39a96e3283a58122025-08-20T03:54:52ZengWileyInternational Journal of Breast Cancer2090-31702090-31892014-01-01201410.1155/2014/327081327081Smoking and Breast Cancer Recurrence after Breast Conservation TherapyJennifer D. Bishop0Brigid K. Killelea1Anees B. Chagpar2Nina R. Horowitz3Donald R. Lannin4Department of Surgery and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USADepartment of Surgery and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USADepartment of Surgery and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USADepartment of Surgery and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USADepartment of Surgery and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USABackground. Prior studies have shown earlier recurrence and decreased survival in patients with head and neck cancer who smoked while undergoing radiation therapy. The purpose of the current study was to determine whether smoking status at the time of partial mastectomy and radiation therapy for breast cancer affected recurrence or survival. Method. A single institution retrospective chart review was performed to correlate smoking status with patient demographics, tumor characteristics, and outcomes for patients undergoing partial mastectomy and radiation therapy. Results. There were 624 patients who underwent breast conservation surgery between 2002 and 2010 for whom smoking history and follow-up data were available. Smoking status was associated with race, patient age, and tumor stage, but not with grade, histology, or receptor status. African American women were more likely to be current smokers (22% versus 7%, P<0.001). With a mean follow-up of 45 months, recurrence was significantly higher in current smokers compared to former or never smokers (P=0.039). In a multivariate model adjusted for race and tumor stage, recurrence among current smokers was 6.7 times that of never smokers (CI 2.0–22.4). Conclusions. Although the numbers are small, this study suggests that smoking may negatively influence recurrence rates after partial mastectomy and radiation therapy. A larger study is needed to confirm these observations.http://dx.doi.org/10.1155/2014/327081 |
| spellingShingle | Jennifer D. Bishop Brigid K. Killelea Anees B. Chagpar Nina R. Horowitz Donald R. Lannin Smoking and Breast Cancer Recurrence after Breast Conservation Therapy International Journal of Breast Cancer |
| title | Smoking and Breast Cancer Recurrence after Breast Conservation Therapy |
| title_full | Smoking and Breast Cancer Recurrence after Breast Conservation Therapy |
| title_fullStr | Smoking and Breast Cancer Recurrence after Breast Conservation Therapy |
| title_full_unstemmed | Smoking and Breast Cancer Recurrence after Breast Conservation Therapy |
| title_short | Smoking and Breast Cancer Recurrence after Breast Conservation Therapy |
| title_sort | smoking and breast cancer recurrence after breast conservation therapy |
| url | http://dx.doi.org/10.1155/2014/327081 |
| work_keys_str_mv | AT jenniferdbishop smokingandbreastcancerrecurrenceafterbreastconservationtherapy AT brigidkkillelea smokingandbreastcancerrecurrenceafterbreastconservationtherapy AT aneesbchagpar smokingandbreastcancerrecurrenceafterbreastconservationtherapy AT ninarhorowitz smokingandbreastcancerrecurrenceafterbreastconservationtherapy AT donaldrlannin smokingandbreastcancerrecurrenceafterbreastconservationtherapy |