Frontal Plane QRS – T Angle Is a Predictor of Ventricular Arrhythmia in Heart Failure With Preserved Ejection Fraction
ABSTRACT Introduction Various ventricular repolarization parameters are known to predict ventricular arrhythmias and mortality in various diseases. Although mortality in patients with heart failure with preserved ejection fraction (HFpEF) is similar to that in heart failure with reduced ejection fra...
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Wiley
2025-03-01
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| Series: | Annals of Noninvasive Electrocardiology |
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| Online Access: | https://doi.org/10.1111/anec.70062 |
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| author | Çağrı Zorlu Barış Açıkel Sefa Erdi Ömür |
| author_facet | Çağrı Zorlu Barış Açıkel Sefa Erdi Ömür |
| author_sort | Çağrı Zorlu |
| collection | DOAJ |
| description | ABSTRACT Introduction Various ventricular repolarization parameters are known to predict ventricular arrhythmias and mortality in various diseases. Although mortality in patients with heart failure with preserved ejection fraction (HFpEF) is similar to that in heart failure with reduced ejection fraction patients, studies on this subject are more limited. Therefore, it is important to evaluate the relationship between ventricular arrhythmias and mortality and ventricular repolarization parameters, especially the frontal plane QRS–T angle, in patients with HFpEF. Methods Electrocardiographic, echocardiographic, and laboratory data of 811 patients were evaluated, and the fQRST angle was calculated on ECG. The occurrence of ventricular tachycardia, ventricular fibrillation, or sudden death within a mean of 48 ± 12 months was recorded. Statistical significance was determined as p < 0.05. Results A total of 811 patients were evaluated, 180 patients in the cardiac event group and 631 patients in the no cardiac event group. NT‐proBNP, La size, La volume index, Tp‐e time, Tp‐e/QTc ratio, and fQRS‐T angle were statistically significantly higher in the cardiac event group. NT‐proBNP level and fQRS‐T angle were found to be independent predictors of mortality in multivariate cox analysis. According to ROC analysis, when QRS‐T angle has a cut‐off value of 58.63, its sensitivity is 81.2, and its specificity is 79.3. Kaplan‐Meier analysis also found that when the fQRS‐T angle was > 58.63, mortality was higher than at narrower angles. Conclusions According to our study, the fQRS‐T angle, which can be easily and inexpensively calculated on ECG, predicts long‐term ventricular arrhythmias in patients with HFpEF. |
| format | Article |
| id | doaj-art-203c68a3e8744df19018deddd7a8bb2c |
| institution | Kabale University |
| issn | 1082-720X 1542-474X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Noninvasive Electrocardiology |
| spelling | doaj-art-203c68a3e8744df19018deddd7a8bb2c2025-08-20T03:44:24ZengWileyAnnals of Noninvasive Electrocardiology1082-720X1542-474X2025-03-01302n/an/a10.1111/anec.70062Frontal Plane QRS – T Angle Is a Predictor of Ventricular Arrhythmia in Heart Failure With Preserved Ejection FractionÇağrı Zorlu0Barış Açıkel1Sefa Erdi Ömür2Department of Cardiology Tokat Gaziosmanpasa University Hospital Tokat TurkeyDepartment of Cardiology Tokat State Hospital Toakt TurkeyDepartment of Cardiology Tokat Gaziosmanpasa University Hospital Tokat TurkeyABSTRACT Introduction Various ventricular repolarization parameters are known to predict ventricular arrhythmias and mortality in various diseases. Although mortality in patients with heart failure with preserved ejection fraction (HFpEF) is similar to that in heart failure with reduced ejection fraction patients, studies on this subject are more limited. Therefore, it is important to evaluate the relationship between ventricular arrhythmias and mortality and ventricular repolarization parameters, especially the frontal plane QRS–T angle, in patients with HFpEF. Methods Electrocardiographic, echocardiographic, and laboratory data of 811 patients were evaluated, and the fQRST angle was calculated on ECG. The occurrence of ventricular tachycardia, ventricular fibrillation, or sudden death within a mean of 48 ± 12 months was recorded. Statistical significance was determined as p < 0.05. Results A total of 811 patients were evaluated, 180 patients in the cardiac event group and 631 patients in the no cardiac event group. NT‐proBNP, La size, La volume index, Tp‐e time, Tp‐e/QTc ratio, and fQRS‐T angle were statistically significantly higher in the cardiac event group. NT‐proBNP level and fQRS‐T angle were found to be independent predictors of mortality in multivariate cox analysis. According to ROC analysis, when QRS‐T angle has a cut‐off value of 58.63, its sensitivity is 81.2, and its specificity is 79.3. Kaplan‐Meier analysis also found that when the fQRS‐T angle was > 58.63, mortality was higher than at narrower angles. Conclusions According to our study, the fQRS‐T angle, which can be easily and inexpensively calculated on ECG, predicts long‐term ventricular arrhythmias in patients with HFpEF.https://doi.org/10.1111/anec.70062echocardiography/methodselectrocardiography/methodsfrontal plane QRSheart failure with preserved ejection fractionmortalityventricular arrhythmias |
| spellingShingle | Çağrı Zorlu Barış Açıkel Sefa Erdi Ömür Frontal Plane QRS – T Angle Is a Predictor of Ventricular Arrhythmia in Heart Failure With Preserved Ejection Fraction Annals of Noninvasive Electrocardiology echocardiography/methods electrocardiography/methods frontal plane QRS heart failure with preserved ejection fraction mortality ventricular arrhythmias |
| title | Frontal Plane QRS – T Angle Is a Predictor of Ventricular Arrhythmia in Heart Failure With Preserved Ejection Fraction |
| title_full | Frontal Plane QRS – T Angle Is a Predictor of Ventricular Arrhythmia in Heart Failure With Preserved Ejection Fraction |
| title_fullStr | Frontal Plane QRS – T Angle Is a Predictor of Ventricular Arrhythmia in Heart Failure With Preserved Ejection Fraction |
| title_full_unstemmed | Frontal Plane QRS – T Angle Is a Predictor of Ventricular Arrhythmia in Heart Failure With Preserved Ejection Fraction |
| title_short | Frontal Plane QRS – T Angle Is a Predictor of Ventricular Arrhythmia in Heart Failure With Preserved Ejection Fraction |
| title_sort | frontal plane qrs t angle is a predictor of ventricular arrhythmia in heart failure with preserved ejection fraction |
| topic | echocardiography/methods electrocardiography/methods frontal plane QRS heart failure with preserved ejection fraction mortality ventricular arrhythmias |
| url | https://doi.org/10.1111/anec.70062 |
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