Staging of Primary Abdominal Lymphomas: Comparison of Whole-Body MRI with Diffusion-Weighted Imaging and 18F-FDG-PET/CT
Background. The purpose of this study was to compare the accuracy of whole-body MRI with diffusion-weighted sequences (WB-DW-MRI) with that of 18F-FDG-PET/CT in the staging of patients with primary gastrointestinal lymphoma. Methods. This retrospective study involved 17 untreated patients with prima...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/104794 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559059790725120 |
|---|---|
| author | Alessandro Stecco Francesco Buemi Martina Quagliozzi Mariangela Lombardi Alberto Santagostino Gian Mauro Sacchetti Alessandro Carriero |
| author_facet | Alessandro Stecco Francesco Buemi Martina Quagliozzi Mariangela Lombardi Alberto Santagostino Gian Mauro Sacchetti Alessandro Carriero |
| author_sort | Alessandro Stecco |
| collection | DOAJ |
| description | Background. The purpose of this study was to compare the accuracy of whole-body MRI with diffusion-weighted sequences (WB-DW-MRI) with that of 18F-FDG-PET/CT in the staging of patients with primary gastrointestinal lymphoma. Methods. This retrospective study involved 17 untreated patients with primary abdominal gastrointestinal lymphoma. All patients underwent 18F-FDG-PET/CT and WB-DW-MRI. Histopathology findings or at least 6 months of clinical and radiological follow-up was the gold standard. The Musshoff-modified Ann Arbor system was used for staging, and diagnostic accuracy was evaluated on a per-node basis. Results. WB-DW-MRI exhibited 100% sensitivity, 96.3% specificity, and 96.1% and 100% positive and negative predictive values (PPV and NPV), respectively. The sensitivity, specificity, and PPV and NPV of PET/CT were 95.9%, 100%, and 100% and 96.4%, respectively. There were no statistically significant differences between the two techniques p=0.05. The weighted kappa agreement statistics with a 95% confidence interval were 0.97 (0.95–0.99) between the two MRI readers and 0.87 (0.82–0.92) between the two methods. Conclusions. WB-DW-MRI appears to have a comparable diagnostic value to 18F-FDG-PET/CT in staging patients with gastrointestinal lymphoma. |
| format | Article |
| id | doaj-art-203b9b24a7b047feb73ecdae279a8f95 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-203b9b24a7b047feb73ecdae279a8f952025-02-03T01:30:55ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/104794104794Staging of Primary Abdominal Lymphomas: Comparison of Whole-Body MRI with Diffusion-Weighted Imaging and 18F-FDG-PET/CTAlessandro Stecco0Francesco Buemi1Martina Quagliozzi2Mariangela Lombardi3Alberto Santagostino4Gian Mauro Sacchetti5Alessandro Carriero6Radiology Department, “Maggiore della Carità” University Hospital, University of Eastern Piedmont, Corso Mazzini 18, 28100 Novara, ItalyRadiology Department, “Maggiore della Carità” University Hospital, University of Eastern Piedmont, Corso Mazzini 18, 28100 Novara, ItalyRadiology Department, “Maggiore della Carità” University Hospital, University of Eastern Piedmont, Corso Mazzini 18, 28100 Novara, ItalyRadiology Department, “Maggiore della Carità” University Hospital, University of Eastern Piedmont, Corso Mazzini 18, 28100 Novara, ItalyOncohaematology Department, Sant’Andrea Hospital, Corso Mario Abbiate 21, 13100 Vercelli, ItalyNuclear Medicine Department, “Maggiore della Carità” University Hospital, University of Eastern Piedmont, Corso Mazzini 18, 28100 Novara, ItalyRadiology Department, “Maggiore della Carità” University Hospital, University of Eastern Piedmont, Corso Mazzini 18, 28100 Novara, ItalyBackground. The purpose of this study was to compare the accuracy of whole-body MRI with diffusion-weighted sequences (WB-DW-MRI) with that of 18F-FDG-PET/CT in the staging of patients with primary gastrointestinal lymphoma. Methods. This retrospective study involved 17 untreated patients with primary abdominal gastrointestinal lymphoma. All patients underwent 18F-FDG-PET/CT and WB-DW-MRI. Histopathology findings or at least 6 months of clinical and radiological follow-up was the gold standard. The Musshoff-modified Ann Arbor system was used for staging, and diagnostic accuracy was evaluated on a per-node basis. Results. WB-DW-MRI exhibited 100% sensitivity, 96.3% specificity, and 96.1% and 100% positive and negative predictive values (PPV and NPV), respectively. The sensitivity, specificity, and PPV and NPV of PET/CT were 95.9%, 100%, and 100% and 96.4%, respectively. There were no statistically significant differences between the two techniques p=0.05. The weighted kappa agreement statistics with a 95% confidence interval were 0.97 (0.95–0.99) between the two MRI readers and 0.87 (0.82–0.92) between the two methods. Conclusions. WB-DW-MRI appears to have a comparable diagnostic value to 18F-FDG-PET/CT in staging patients with gastrointestinal lymphoma.http://dx.doi.org/10.1155/2015/104794 |
| spellingShingle | Alessandro Stecco Francesco Buemi Martina Quagliozzi Mariangela Lombardi Alberto Santagostino Gian Mauro Sacchetti Alessandro Carriero Staging of Primary Abdominal Lymphomas: Comparison of Whole-Body MRI with Diffusion-Weighted Imaging and 18F-FDG-PET/CT Gastroenterology Research and Practice |
| title | Staging of Primary Abdominal Lymphomas: Comparison of Whole-Body MRI with Diffusion-Weighted Imaging and 18F-FDG-PET/CT |
| title_full | Staging of Primary Abdominal Lymphomas: Comparison of Whole-Body MRI with Diffusion-Weighted Imaging and 18F-FDG-PET/CT |
| title_fullStr | Staging of Primary Abdominal Lymphomas: Comparison of Whole-Body MRI with Diffusion-Weighted Imaging and 18F-FDG-PET/CT |
| title_full_unstemmed | Staging of Primary Abdominal Lymphomas: Comparison of Whole-Body MRI with Diffusion-Weighted Imaging and 18F-FDG-PET/CT |
| title_short | Staging of Primary Abdominal Lymphomas: Comparison of Whole-Body MRI with Diffusion-Weighted Imaging and 18F-FDG-PET/CT |
| title_sort | staging of primary abdominal lymphomas comparison of whole body mri with diffusion weighted imaging and 18f fdg pet ct |
| url | http://dx.doi.org/10.1155/2015/104794 |
| work_keys_str_mv | AT alessandrostecco stagingofprimaryabdominallymphomascomparisonofwholebodymriwithdiffusionweightedimagingand18ffdgpetct AT francescobuemi stagingofprimaryabdominallymphomascomparisonofwholebodymriwithdiffusionweightedimagingand18ffdgpetct AT martinaquagliozzi stagingofprimaryabdominallymphomascomparisonofwholebodymriwithdiffusionweightedimagingand18ffdgpetct AT mariangelalombardi stagingofprimaryabdominallymphomascomparisonofwholebodymriwithdiffusionweightedimagingand18ffdgpetct AT albertosantagostino stagingofprimaryabdominallymphomascomparisonofwholebodymriwithdiffusionweightedimagingand18ffdgpetct AT gianmaurosacchetti stagingofprimaryabdominallymphomascomparisonofwholebodymriwithdiffusionweightedimagingand18ffdgpetct AT alessandrocarriero stagingofprimaryabdominallymphomascomparisonofwholebodymriwithdiffusionweightedimagingand18ffdgpetct |