The Modulation of Neuroimmune Responses in Peripheral Inflammation
Jing Wang,1 Dandan Ji,2 Ninan Dai,1 Chang Qin,1 Mingyang Gong,1 Bao Fu1 1Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People’s Republic of China; 2Department of Intensive Care Unit, Zhejiang Province People’s Hospital Bijie Hospital, Bijie, G...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-07-01
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| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-modulation-of-neuroimmune-responses-in-peripheral-inflammation-peer-reviewed-fulltext-article-JIR |
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| Summary: | Jing Wang,1 Dandan Ji,2 Ninan Dai,1 Chang Qin,1 Mingyang Gong,1 Bao Fu1 1Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People’s Republic of China; 2Department of Intensive Care Unit, Zhejiang Province People’s Hospital Bijie Hospital, Bijie, Guizhou, People’s Republic of ChinaCorrespondence: Bao Fu, Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Dalian Road149, Zunyi, Guizhou, 563000, People’s Republic of China, Tel +86 851 2860 8514, Email fubao0607@126.comAbstract: The brain, as the “commander-in-chief” of the human body, is known to pick up the peripheral situation and dictate orders to the periphery on time, and the immune system makes no exception. Inflammation is a defensive reaction of the body, which can be beneficial, however, unrestricted inflammation can result in life-threatening injuries and multi-organ dysfunction. The intricate interaction between the nervous and the immune system would prevent inflammation from spreading indefinitely. The onset of life-threatening bursts of inflammation may indicate neurological dysregulation, at which point additional interventions are necessary to establish a new balance. However, these interventions must be predicated on an understanding of the neuroimmune communication. Consequently, we provide a comprehensive pathway that illustrates how the central nervous system detects peripheral inflammatory signals that are transmitted by nerves or related substances and subsequently regulates peripheral inflammation through the autonomic nervous system and neuroendocrine system, intending to discover new methods of treating peripheral inflammation by intervening the nervous system.Keywords: central nervous system, peripheral inflammation, vagus nerve, neuroimmune |
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| ISSN: | 1178-7031 |