Association between Interferon-Inducible Protein 6 () Polymorphisms and Hepatitis B Virus Clearance
CD8+ T cells are key factors mediating hepatitis B virus (HBV) clearance. However, these cells are killed through HBV-induced apoptosis during the antigen-presenting period in HBV-induced chronic liver disease (CLD) patients. Interferon-inducible protein 6 (IFI6) delays type I interferon-induced apo...
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BioMed Central
2013-03-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-11-15.pdf |
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| author | Geun-Hee Park Kyoung-Yeon Kim Sung Won Cho Jae Youn Cheong Gyeong Im Yu Dong Hoon Shin Kyu Bum Kwack |
| author_facet | Geun-Hee Park Kyoung-Yeon Kim Sung Won Cho Jae Youn Cheong Gyeong Im Yu Dong Hoon Shin Kyu Bum Kwack |
| author_sort | Geun-Hee Park |
| collection | DOAJ |
| description | CD8+ T cells are key factors mediating hepatitis B virus (HBV) clearance. However, these cells are killed through HBV-induced apoptosis during the antigen-presenting period in HBV-induced chronic liver disease (CLD) patients. Interferon-inducible protein 6 (IFI6) delays type I interferon-induced apoptosis in cells. We hypothesized that single nucleotide polymorphisms (SNPs) in the IFI6 could affect the chronicity of CLD. The present study included a discovery stage, in which 195 CLD patients, including chronic hepatitis B (HEP) and cirrhosis patients and 107 spontaneous recovery (SR) controls, were analyzed. The genotype distributions of rs2808426 (C > T) and rs10902662 (C > T) were significantly different between the SR and HEP groups (odds ratio [OR], 6.60; 95% confidence interval [CI], 1.64 to 26.52, p = 0.008 for both SNPs) and between the SR and CLD groups (OR, 4.38; 95% CI, 1.25 to 15.26; p = 0.021 and OR, 4.12; 95% CI, 1.18 to 14.44; p = 0.027, respectively). The distribution of diplotypes that contained these SNPs was significantly different between the SR and HEP groups (OR, 6.58; 95% CI, 1.63 to 25.59; p = 0.008 and OR, 0.15; 95% CI, 0.04 to 0.61; p = 0.008, respectively) and between the SR and CLD groups (OR, 4.38; 95% CI, 1.25 to 15.26; p = 0.021 and OR, 4.12; 95% CI, 1.18 to 14.44; p = 0.027, respectively). We were unable to replicate the association shown by secondary enrolled samples. A large-scale validation study should be performed to confirm the association between IFI6 and HBV clearance. |
| format | Article |
| id | doaj-art-2021dbc22ff14727bb95338eaab22c39 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2013-03-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-2021dbc22ff14727bb95338eaab22c392025-02-02T18:04:07ZengBioMed CentralGenomics & Informatics1598-866X2234-07422013-03-01111152310.5808/GI.2013.11.1.1554Association between Interferon-Inducible Protein 6 () Polymorphisms and Hepatitis B Virus ClearanceGeun-Hee Park0Kyoung-Yeon Kim1Sung Won Cho2Jae Youn Cheong3Gyeong Im Yu4Dong Hoon Shin5Kyu Bum Kwack6Department of Biomedical Science, College of Life Science, CHA University, Seongnam 463-836, Korea.Department of Biomedical Science, College of Life Science, CHA University, Seongnam 463-836, Korea.Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine, Suwon 442-749, Korea.Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine, Suwon 442-749, Korea.Department of Preventive Medicine, Keimyung University School of Medicine, Daegu 700-712, Korea.Department of Preventive Medicine, Keimyung University School of Medicine, Daegu 700-712, Korea.Department of Biomedical Science, College of Life Science, CHA University, Seongnam 463-836, Korea.CD8+ T cells are key factors mediating hepatitis B virus (HBV) clearance. However, these cells are killed through HBV-induced apoptosis during the antigen-presenting period in HBV-induced chronic liver disease (CLD) patients. Interferon-inducible protein 6 (IFI6) delays type I interferon-induced apoptosis in cells. We hypothesized that single nucleotide polymorphisms (SNPs) in the IFI6 could affect the chronicity of CLD. The present study included a discovery stage, in which 195 CLD patients, including chronic hepatitis B (HEP) and cirrhosis patients and 107 spontaneous recovery (SR) controls, were analyzed. The genotype distributions of rs2808426 (C > T) and rs10902662 (C > T) were significantly different between the SR and HEP groups (odds ratio [OR], 6.60; 95% confidence interval [CI], 1.64 to 26.52, p = 0.008 for both SNPs) and between the SR and CLD groups (OR, 4.38; 95% CI, 1.25 to 15.26; p = 0.021 and OR, 4.12; 95% CI, 1.18 to 14.44; p = 0.027, respectively). The distribution of diplotypes that contained these SNPs was significantly different between the SR and HEP groups (OR, 6.58; 95% CI, 1.63 to 25.59; p = 0.008 and OR, 0.15; 95% CI, 0.04 to 0.61; p = 0.008, respectively) and between the SR and CLD groups (OR, 4.38; 95% CI, 1.25 to 15.26; p = 0.021 and OR, 4.12; 95% CI, 1.18 to 14.44; p = 0.027, respectively). We were unable to replicate the association shown by secondary enrolled samples. A large-scale validation study should be performed to confirm the association between IFI6 and HBV clearance.http://genominfo.org/upload/pdf/gni-11-15.pdfhepatitis B virussingle nucleotide polymorphism |
| spellingShingle | Geun-Hee Park Kyoung-Yeon Kim Sung Won Cho Jae Youn Cheong Gyeong Im Yu Dong Hoon Shin Kyu Bum Kwack Association between Interferon-Inducible Protein 6 () Polymorphisms and Hepatitis B Virus Clearance Genomics & Informatics hepatitis B virus single nucleotide polymorphism |
| title | Association between Interferon-Inducible Protein 6 () Polymorphisms and Hepatitis B Virus Clearance |
| title_full | Association between Interferon-Inducible Protein 6 () Polymorphisms and Hepatitis B Virus Clearance |
| title_fullStr | Association between Interferon-Inducible Protein 6 () Polymorphisms and Hepatitis B Virus Clearance |
| title_full_unstemmed | Association between Interferon-Inducible Protein 6 () Polymorphisms and Hepatitis B Virus Clearance |
| title_short | Association between Interferon-Inducible Protein 6 () Polymorphisms and Hepatitis B Virus Clearance |
| title_sort | association between interferon inducible protein 6 polymorphisms and hepatitis b virus clearance |
| topic | hepatitis B virus single nucleotide polymorphism |
| url | http://genominfo.org/upload/pdf/gni-11-15.pdf |
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