Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis
Abstract Ferroptosis, a regulated type of cell death directed by iron-dependent lipid peroxidation, is associated with a variety of pathological diseases. Recent findings have highlighted the therapeutic potential of mesenchymal stem cell-derived exosomes (MSC-Exos) in modulating ferroptosis. These...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-025-04511-2 |
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| author | Mohammed Zayed Enas Elwakeel Prehan Ezzat Byung-Hoon Jeong |
| author_facet | Mohammed Zayed Enas Elwakeel Prehan Ezzat Byung-Hoon Jeong |
| author_sort | Mohammed Zayed |
| collection | DOAJ |
| description | Abstract Ferroptosis, a regulated type of cell death directed by iron-dependent lipid peroxidation, is associated with a variety of pathological diseases. Recent findings have highlighted the therapeutic potential of mesenchymal stem cell-derived exosomes (MSC-Exos) in modulating ferroptosis. These nano-sized extracellular vesicles carry bioactive substances, including proteins, lipids, and microRNAs, which regulate vital pathways related to ferroptosis, such as reactive oxygen species production, glutathione metabolism, and lipid peroxidation. Preclinical studies suggest that MSC-Exos can alleviate ferroptosis-induced damage by enhancing antioxidant defenses, mitigating oxidative stress, upregulating anti-ferroptotic regulators, and suppressing lipid peroxidation. Notably, in cancer, MSC-Exos may protect non-malignant tissues from chemotherapy-induced ferroptosis. By exploiting their regenerative and immunomodulatory properties, MSC-Exos offer a promising therapeutic platform for targeting ferroptosis in diverse pathological conditions. This review summarizes the biological and functional characteristics of MSC-Exos, elucidates their roles in ferroptosis regulation across multiple disease models, and discusses current challenges and future directions for clinical translation. |
| format | Article |
| id | doaj-art-20201cccb32949d1b53da98249f1b8e4 |
| institution | DOAJ |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-20201cccb32949d1b53da98249f1b8e42025-08-20T03:04:30ZengBMCStem Cell Research & Therapy1757-65122025-07-0116112210.1186/s13287-025-04511-2Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosisMohammed Zayed0Enas Elwakeel1Prehan Ezzat2Byung-Hoon Jeong3Korea Zoonosis Research Institute, Jeonbuk National UniversityFaculty of Dentistry, Tanta UniversityMolecular Biology Unit, Department of Zoology, Faculty of Science, Alexandria UniversityKorea Zoonosis Research Institute, Jeonbuk National UniversityAbstract Ferroptosis, a regulated type of cell death directed by iron-dependent lipid peroxidation, is associated with a variety of pathological diseases. Recent findings have highlighted the therapeutic potential of mesenchymal stem cell-derived exosomes (MSC-Exos) in modulating ferroptosis. These nano-sized extracellular vesicles carry bioactive substances, including proteins, lipids, and microRNAs, which regulate vital pathways related to ferroptosis, such as reactive oxygen species production, glutathione metabolism, and lipid peroxidation. Preclinical studies suggest that MSC-Exos can alleviate ferroptosis-induced damage by enhancing antioxidant defenses, mitigating oxidative stress, upregulating anti-ferroptotic regulators, and suppressing lipid peroxidation. Notably, in cancer, MSC-Exos may protect non-malignant tissues from chemotherapy-induced ferroptosis. By exploiting their regenerative and immunomodulatory properties, MSC-Exos offer a promising therapeutic platform for targeting ferroptosis in diverse pathological conditions. This review summarizes the biological and functional characteristics of MSC-Exos, elucidates their roles in ferroptosis regulation across multiple disease models, and discusses current challenges and future directions for clinical translation.https://doi.org/10.1186/s13287-025-04511-2Mesenchymal stem cellsExosomesCell deathFerroptosisNeurodegenerative diseasesCancer |
| spellingShingle | Mohammed Zayed Enas Elwakeel Prehan Ezzat Byung-Hoon Jeong Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis Stem Cell Research & Therapy Mesenchymal stem cells Exosomes Cell death Ferroptosis Neurodegenerative diseases Cancer |
| title | Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis |
| title_full | Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis |
| title_fullStr | Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis |
| title_full_unstemmed | Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis |
| title_short | Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis |
| title_sort | mesenchymal stem cell derived exosomes as a potential therapeutic strategy for ferroptosis |
| topic | Mesenchymal stem cells Exosomes Cell death Ferroptosis Neurodegenerative diseases Cancer |
| url | https://doi.org/10.1186/s13287-025-04511-2 |
| work_keys_str_mv | AT mohammedzayed mesenchymalstemcellderivedexosomesasapotentialtherapeuticstrategyforferroptosis AT enaselwakeel mesenchymalstemcellderivedexosomesasapotentialtherapeuticstrategyforferroptosis AT prehanezzat mesenchymalstemcellderivedexosomesasapotentialtherapeuticstrategyforferroptosis AT byunghoonjeong mesenchymalstemcellderivedexosomesasapotentialtherapeuticstrategyforferroptosis |