Telomere-to-telomere DNA replication timing profiling using single-molecule sequencing with Nanotiming

Telomere-to-telomere DNA replication timing profiling using single-molecule sequencing with Nanotiming

Abstract Current temporal studies of DNA replication are either low-resolution or require complex cell synchronisation and/or sorting procedures. Here we introduce Nanotiming, a single-molecule, nanopore sequencing-based method producing high-resolution, telomere-to-telomere replication timing (RT)...

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Bibliographic Details
Main Authors: Bertrand Theulot, Alan Tourancheau, Emma Simonin Chavignier, Etienne Jean, Jean-Michel Arbona, Benjamin Audit, Olivier Hyrien, Laurent Lacroix, Benoît Le Tallec
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55520-3
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