Abnormal Cerebrovascular Reactivity in Patients with Parkinson’s Disease
Background. Orthostatic hypotension (OH) is an important nonmotor manifestation of Parkinson’s disease (PD). Changes in cerebrovascular reactivity may contribute to this manifestation and can be monitored using transcranial Doppler. Objective. To identify possible changes in cerebrovascular reactivi...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/523041 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566665926148096 |
|---|---|
| author | Carlos Henrique Ferreira Camargo Eduardo Antunes Martins Marcos Christiano Lange Henrique Alvaro Hoffmann Jissa Jeanete Luciano Marcelo Rezende Young Blood Marcelo Derbli Schafranski Marcelo Machado Ferro Edmar Miyoshi |
| author_facet | Carlos Henrique Ferreira Camargo Eduardo Antunes Martins Marcos Christiano Lange Henrique Alvaro Hoffmann Jissa Jeanete Luciano Marcelo Rezende Young Blood Marcelo Derbli Schafranski Marcelo Machado Ferro Edmar Miyoshi |
| author_sort | Carlos Henrique Ferreira Camargo |
| collection | DOAJ |
| description | Background. Orthostatic hypotension (OH) is an important nonmotor manifestation of Parkinson’s disease (PD). Changes in cerebrovascular reactivity may contribute to this manifestation and can be monitored using transcranial Doppler. Objective. To identify possible changes in cerebrovascular reactivity in patients with OH. Methods. Twenty-two individuals were selected and divided into three groups: with and without OH and controls. Transcranial Doppler was used to assess basal mean blood flow velocity, postapnea mean blood flow velocity, percentage increase in mean blood flow velocity, and cerebrovascular reactivity as measured by the breath-holding index. Results. PD patients had lower values of basal velocity (p=0.019), postapnea velocity (p=0.0015), percentage increase in velocity (p=0.039), and breath-holding index (p=0.04) than the controls. Patients with OH had higher values of basal velocity (p=0.09) and postapnea velocity (p=0.19) but lower values of percentage increase in velocity (p=0.22) and breath-holding index (p=0.32) than patients without OH. Conclusions. PD patients present with abnormalities in a compensatory mechanism that regulates cerebral blood flow. OH could be an indicator of these abnormalities. |
| format | Article |
| id | doaj-art-2014e845891f4ce482c2a71a7b4dec35 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-2014e845891f4ce482c2a71a7b4dec352025-02-03T01:03:26ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/523041523041Abnormal Cerebrovascular Reactivity in Patients with Parkinson’s DiseaseCarlos Henrique Ferreira Camargo0Eduardo Antunes Martins1Marcos Christiano Lange2Henrique Alvaro Hoffmann3Jissa Jeanete Luciano4Marcelo Rezende Young Blood5Marcelo Derbli Schafranski6Marcelo Machado Ferro7Edmar Miyoshi8State University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, BrazilState University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, BrazilHospital de Clínicas, Federal University of Paraná, Rua General Carneiro 181, 80060-900 Curitiba, PR, BrazilState University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, BrazilState University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, BrazilState University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, BrazilState University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, BrazilState University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, BrazilState University of Ponta Grossa, Avenida General Carlos Cavalcanti 4748, 84030-900 Ponta Grossa, PR, BrazilBackground. Orthostatic hypotension (OH) is an important nonmotor manifestation of Parkinson’s disease (PD). Changes in cerebrovascular reactivity may contribute to this manifestation and can be monitored using transcranial Doppler. Objective. To identify possible changes in cerebrovascular reactivity in patients with OH. Methods. Twenty-two individuals were selected and divided into three groups: with and without OH and controls. Transcranial Doppler was used to assess basal mean blood flow velocity, postapnea mean blood flow velocity, percentage increase in mean blood flow velocity, and cerebrovascular reactivity as measured by the breath-holding index. Results. PD patients had lower values of basal velocity (p=0.019), postapnea velocity (p=0.0015), percentage increase in velocity (p=0.039), and breath-holding index (p=0.04) than the controls. Patients with OH had higher values of basal velocity (p=0.09) and postapnea velocity (p=0.19) but lower values of percentage increase in velocity (p=0.22) and breath-holding index (p=0.32) than patients without OH. Conclusions. PD patients present with abnormalities in a compensatory mechanism that regulates cerebral blood flow. OH could be an indicator of these abnormalities.http://dx.doi.org/10.1155/2015/523041 |
| spellingShingle | Carlos Henrique Ferreira Camargo Eduardo Antunes Martins Marcos Christiano Lange Henrique Alvaro Hoffmann Jissa Jeanete Luciano Marcelo Rezende Young Blood Marcelo Derbli Schafranski Marcelo Machado Ferro Edmar Miyoshi Abnormal Cerebrovascular Reactivity in Patients with Parkinson’s Disease Parkinson's Disease |
| title | Abnormal Cerebrovascular Reactivity in Patients with Parkinson’s Disease |
| title_full | Abnormal Cerebrovascular Reactivity in Patients with Parkinson’s Disease |
| title_fullStr | Abnormal Cerebrovascular Reactivity in Patients with Parkinson’s Disease |
| title_full_unstemmed | Abnormal Cerebrovascular Reactivity in Patients with Parkinson’s Disease |
| title_short | Abnormal Cerebrovascular Reactivity in Patients with Parkinson’s Disease |
| title_sort | abnormal cerebrovascular reactivity in patients with parkinson s disease |
| url | http://dx.doi.org/10.1155/2015/523041 |
| work_keys_str_mv | AT carloshenriqueferreiracamargo abnormalcerebrovascularreactivityinpatientswithparkinsonsdisease AT eduardoantunesmartins abnormalcerebrovascularreactivityinpatientswithparkinsonsdisease AT marcoschristianolange abnormalcerebrovascularreactivityinpatientswithparkinsonsdisease AT henriquealvarohoffmann abnormalcerebrovascularreactivityinpatientswithparkinsonsdisease AT jissajeaneteluciano abnormalcerebrovascularreactivityinpatientswithparkinsonsdisease AT marcelorezendeyoungblood abnormalcerebrovascularreactivityinpatientswithparkinsonsdisease AT marceloderblischafranski abnormalcerebrovascularreactivityinpatientswithparkinsonsdisease AT marcelomachadoferro abnormalcerebrovascularreactivityinpatientswithparkinsonsdisease AT edmarmiyoshi abnormalcerebrovascularreactivityinpatientswithparkinsonsdisease |