Metastatic Renal Cell Carcinoma with Level IV Thrombus: Contemporary Management with Complete Response to Neoadjuvant Targeted Therapy
Renal cell carcinoma, particularly the most common clear cell type, is one of the most aggressive of urological cancers with significant risk of metastatic spread. It also has a propensity for venotropism with a proportion of tumors developing thrombi up to the right atrium. The response with newly...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2019/7102504 |
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| _version_ | 1832553317952126976 |
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| author | Abhishek Bhat Bruno Nahar Vivek Venkatramani Indraneel Banerjee Oleksandr N. Kryvenko Dipen J. Parekh |
| author_facet | Abhishek Bhat Bruno Nahar Vivek Venkatramani Indraneel Banerjee Oleksandr N. Kryvenko Dipen J. Parekh |
| author_sort | Abhishek Bhat |
| collection | DOAJ |
| description | Renal cell carcinoma, particularly the most common clear cell type, is one of the most aggressive of urological cancers with significant risk of metastatic spread. It also has a propensity for venotropism with a proportion of tumors developing thrombi up to the right atrium. The response with newly adopted targeted therapy has been considered to be in the evolutionary stage with no clear role with respect to debulking or reducing the size of the inferior vena cava (IVC) thrombus. We describe a case of a right-sided metastatic RCC with Level IV thrombus initially managed with Pazopanib followed by Nivolumab and Adalimumab followed by cytoreductive nephrectomy and IVC thrombectomy in the post-targeted therapy setting with complete curative response. |
| format | Article |
| id | doaj-art-200aca4bb32f446588021bf3d23878dd |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-200aca4bb32f446588021bf3d23878dd2025-02-03T05:54:15ZengWileyCase Reports in Urology2090-696X2090-69782019-01-01201910.1155/2019/71025047102504Metastatic Renal Cell Carcinoma with Level IV Thrombus: Contemporary Management with Complete Response to Neoadjuvant Targeted TherapyAbhishek Bhat0Bruno Nahar1Vivek Venkatramani2Indraneel Banerjee3Oleksandr N. Kryvenko4Dipen J. Parekh5Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USADepartment of Urology, University of Miami Miller School of Medicine, Miami, FL, USADepartment of Urology, University of Miami Miller School of Medicine, Miami, FL, USADepartment of Urology, University of Miami Miller School of Medicine, Miami, FL, USADepartment of Urology, University of Miami Miller School of Medicine, Miami, FL, USADepartment of Urology, University of Miami Miller School of Medicine, Miami, FL, USARenal cell carcinoma, particularly the most common clear cell type, is one of the most aggressive of urological cancers with significant risk of metastatic spread. It also has a propensity for venotropism with a proportion of tumors developing thrombi up to the right atrium. The response with newly adopted targeted therapy has been considered to be in the evolutionary stage with no clear role with respect to debulking or reducing the size of the inferior vena cava (IVC) thrombus. We describe a case of a right-sided metastatic RCC with Level IV thrombus initially managed with Pazopanib followed by Nivolumab and Adalimumab followed by cytoreductive nephrectomy and IVC thrombectomy in the post-targeted therapy setting with complete curative response.http://dx.doi.org/10.1155/2019/7102504 |
| spellingShingle | Abhishek Bhat Bruno Nahar Vivek Venkatramani Indraneel Banerjee Oleksandr N. Kryvenko Dipen J. Parekh Metastatic Renal Cell Carcinoma with Level IV Thrombus: Contemporary Management with Complete Response to Neoadjuvant Targeted Therapy Case Reports in Urology |
| title | Metastatic Renal Cell Carcinoma with Level IV Thrombus: Contemporary Management with Complete Response to Neoadjuvant Targeted Therapy |
| title_full | Metastatic Renal Cell Carcinoma with Level IV Thrombus: Contemporary Management with Complete Response to Neoadjuvant Targeted Therapy |
| title_fullStr | Metastatic Renal Cell Carcinoma with Level IV Thrombus: Contemporary Management with Complete Response to Neoadjuvant Targeted Therapy |
| title_full_unstemmed | Metastatic Renal Cell Carcinoma with Level IV Thrombus: Contemporary Management with Complete Response to Neoadjuvant Targeted Therapy |
| title_short | Metastatic Renal Cell Carcinoma with Level IV Thrombus: Contemporary Management with Complete Response to Neoadjuvant Targeted Therapy |
| title_sort | metastatic renal cell carcinoma with level iv thrombus contemporary management with complete response to neoadjuvant targeted therapy |
| url | http://dx.doi.org/10.1155/2019/7102504 |
| work_keys_str_mv | AT abhishekbhat metastaticrenalcellcarcinomawithlevelivthrombuscontemporarymanagementwithcompleteresponsetoneoadjuvanttargetedtherapy AT brunonahar metastaticrenalcellcarcinomawithlevelivthrombuscontemporarymanagementwithcompleteresponsetoneoadjuvanttargetedtherapy AT vivekvenkatramani metastaticrenalcellcarcinomawithlevelivthrombuscontemporarymanagementwithcompleteresponsetoneoadjuvanttargetedtherapy AT indraneelbanerjee metastaticrenalcellcarcinomawithlevelivthrombuscontemporarymanagementwithcompleteresponsetoneoadjuvanttargetedtherapy AT oleksandrnkryvenko metastaticrenalcellcarcinomawithlevelivthrombuscontemporarymanagementwithcompleteresponsetoneoadjuvanttargetedtherapy AT dipenjparekh metastaticrenalcellcarcinomawithlevelivthrombuscontemporarymanagementwithcompleteresponsetoneoadjuvanttargetedtherapy |