A novel modulator of IL-6R prevents inflammation-induced preterm birth and improves newborn outcome

A novel modulator of IL-6R prevents inflammation-induced preterm birth and improves newborn outcome

Abstract Preterm birth (PTB) is a major cause of neonatal mortality and morbidity. Evidence supports a determinant role for interleukin-6 (IL-6) in the pathophysiology of PTB. Our group developed a small peptide, HSJ633, that antagonizes the interleukin-6 receptor (IL-6R). Binding assays performed o...

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Main Authors: France Côté, Elizabeth Prairie, Estefania Marin Sierra, Christiane Quiniou, Tiffany Habelrih, Wendy Xu, Béatrice Ferri, Xin Hou, Isabelle Lahaie, Nadia Côté, Sarah-Eve Loiselle, Laurence Gobeil, Kevin Sawaya, Aurélie Faucher, Amélie Beaulieu, Sandrine Delisle, Marie-Pénélope Simard, Mohammad Ali Mohammad Nezhady, Véronique Laplante, Allan Reuben, Sidi Mohamed Kalaidji, Emmanuel Bajon, Gael Cagnone, Kelycia B Leimert, Jean-François Gauchat, Luc Gaudreau, Sarah Robertson, William D Lubell, David M Olson, Sylvain Chemtob
Format: Article
Language:English
Published: Springer Nature 2025-07-01
Series:EMBO Molecular Medicine
Subjects:
Inflammation
Interleukin-6
Neonatal Mortality
Non-competitive Modulator
Preterm Birth
Online Access:https://doi.org/10.1038/s44321-025-00257-9
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