Topological Data Analysis in the Assessment of Coronary Atherosclerosis: A Comprehensive Narrative Review
Plaque build-up in the coronary arteries can restrict blood flow or become unstable and contribute to cardiovascular events. Evaluating these plaques is essential for cardiovascular risk stratification and determining the most appropriate treatment strategies. This review aimed to investigate the po...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Mayo Clinic Proceedings: Digital Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949761225000069 |
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| author | Yashbir Singh, ME, PhD Quincy A. Hathaway, MD, PhD Colleen Farrelly, MS Matthew J. Budoff, MD Bradley Erickson, MD, PhD Jeremy D. Collins, MD Michael J. Blaha, MD Tim Leiner, MD, PhD Francisco Lopez-Jimenez, MD, MBA Jennifer Rozenblit, PhD Deepa Sarkar, PhD Gunnar Carlsson, PhD |
| author_facet | Yashbir Singh, ME, PhD Quincy A. Hathaway, MD, PhD Colleen Farrelly, MS Matthew J. Budoff, MD Bradley Erickson, MD, PhD Jeremy D. Collins, MD Michael J. Blaha, MD Tim Leiner, MD, PhD Francisco Lopez-Jimenez, MD, MBA Jennifer Rozenblit, PhD Deepa Sarkar, PhD Gunnar Carlsson, PhD |
| author_sort | Yashbir Singh, ME, PhD |
| collection | DOAJ |
| description | Plaque build-up in the coronary arteries can restrict blood flow or become unstable and contribute to cardiovascular events. Evaluating these plaques is essential for cardiovascular risk stratification and determining the most appropriate treatment strategies. This review aimed to investigate the potential of topological data analysis (TDA), a novel technique, in assessing coronary atherosclerosis. We perform a narrative review of the emerging TDA field, discussing its basic principles and advantages over traditional methods, which often struggle to capture the intricate patterns and relationships within coronary plaques. Topological data analysis can evaluate coronary atherosclerosis in novel ways using variations in the cover and filtration functions of the algorithm, highlighting new ways to characterize calcified and noncalcified plaques. It also highlights the potential of TDA in enhancing the understanding and management of this complex disease. Despite the challenges and future directions, which need to be addressed, TDA shows potential as a valuable tool in assessing coronary atherosclerosis, specifically in noncalcified plaque detection, possibly surpassing traditional techniques in capturing the disease’s intricate patterns. A Pubmed, Google Scholar, Scopus - based literature review was undertaken using the following search terms: Topological data analysis in Coronary atherosclerosis, Topological data analysis in Cardiovascular. |
| format | Article |
| id | doaj-art-2000cd4ee7844ffdb63381df426083f6 |
| institution | OA Journals |
| issn | 2949-7612 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Mayo Clinic Proceedings: Digital Health |
| spelling | doaj-art-2000cd4ee7844ffdb63381df426083f62025-08-20T02:33:38ZengElsevierMayo Clinic Proceedings: Digital Health2949-76122025-06-013210019910.1016/j.mcpdig.2025.100199Topological Data Analysis in the Assessment of Coronary Atherosclerosis: A Comprehensive Narrative ReviewYashbir Singh, ME, PhD0Quincy A. Hathaway, MD, PhD1Colleen Farrelly, MS2Matthew J. Budoff, MD3Bradley Erickson, MD, PhD4Jeremy D. Collins, MD5Michael J. Blaha, MD6Tim Leiner, MD, PhD7Francisco Lopez-Jimenez, MD, MBA8Jennifer Rozenblit, PhD9Deepa Sarkar, PhD10Gunnar Carlsson, PhD11Department of Radiology, Mayo Clinic, Rochester, MN; Correspondence: Address to Yashbir Singh, ME, PhD, Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905.Department of Radiology, University of Pennsylvania, Philadelphia, PAPost Urban Ventures, London, United KingdomLundquist Institute, University of California–Los Angeles, Los Angeles, CADepartment of Radiology, Mayo Clinic, Rochester, MNDepartment of Radiology, Mayo Clinic, Rochester, MNJohns Hopkins Bloomberg School of Public Health, Baltimore, MDDepartment of Radiology, Mayo Clinic, Rochester, MNDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MNDepartment of Mathematics, The University of Texas, Austin, TXInstitute of Genomic Health, Ichan School of Medicine, Mount Sinai, NYDepartment of Mathematics, Stanford University, Stanford, CAPlaque build-up in the coronary arteries can restrict blood flow or become unstable and contribute to cardiovascular events. Evaluating these plaques is essential for cardiovascular risk stratification and determining the most appropriate treatment strategies. This review aimed to investigate the potential of topological data analysis (TDA), a novel technique, in assessing coronary atherosclerosis. We perform a narrative review of the emerging TDA field, discussing its basic principles and advantages over traditional methods, which often struggle to capture the intricate patterns and relationships within coronary plaques. Topological data analysis can evaluate coronary atherosclerosis in novel ways using variations in the cover and filtration functions of the algorithm, highlighting new ways to characterize calcified and noncalcified plaques. It also highlights the potential of TDA in enhancing the understanding and management of this complex disease. Despite the challenges and future directions, which need to be addressed, TDA shows potential as a valuable tool in assessing coronary atherosclerosis, specifically in noncalcified plaque detection, possibly surpassing traditional techniques in capturing the disease’s intricate patterns. A Pubmed, Google Scholar, Scopus - based literature review was undertaken using the following search terms: Topological data analysis in Coronary atherosclerosis, Topological data analysis in Cardiovascular.http://www.sciencedirect.com/science/article/pii/S2949761225000069 |
| spellingShingle | Yashbir Singh, ME, PhD Quincy A. Hathaway, MD, PhD Colleen Farrelly, MS Matthew J. Budoff, MD Bradley Erickson, MD, PhD Jeremy D. Collins, MD Michael J. Blaha, MD Tim Leiner, MD, PhD Francisco Lopez-Jimenez, MD, MBA Jennifer Rozenblit, PhD Deepa Sarkar, PhD Gunnar Carlsson, PhD Topological Data Analysis in the Assessment of Coronary Atherosclerosis: A Comprehensive Narrative Review Mayo Clinic Proceedings: Digital Health |
| title | Topological Data Analysis in the Assessment of Coronary Atherosclerosis: A Comprehensive Narrative Review |
| title_full | Topological Data Analysis in the Assessment of Coronary Atherosclerosis: A Comprehensive Narrative Review |
| title_fullStr | Topological Data Analysis in the Assessment of Coronary Atherosclerosis: A Comprehensive Narrative Review |
| title_full_unstemmed | Topological Data Analysis in the Assessment of Coronary Atherosclerosis: A Comprehensive Narrative Review |
| title_short | Topological Data Analysis in the Assessment of Coronary Atherosclerosis: A Comprehensive Narrative Review |
| title_sort | topological data analysis in the assessment of coronary atherosclerosis a comprehensive narrative review |
| url | http://www.sciencedirect.com/science/article/pii/S2949761225000069 |
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